25-Hydroxyvitamin D level, vitamin D intake, and risk of stroke: A dose–response meta-analysis

Shi, Han; Chen, Hanze; Zhang, Yun; Li, Jinwei; Fu, Kailei; Xue, Weishuang; Wang, Teng; Tian, Li

doi:10.1016/j.clnu.2019.08.029

Cited by 39 publications

(38 citation statements)

References 56 publications

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“…34,35 Higher D vitamin status and intake have been shown to decrease risk of CVD, whereas childhood iron-deficiency anemia is a reported risk factor for ischemic CVD. 36,37 In this study, we found no associations between risk of adult ischemic or hemorrhagic CVD and the duration of breastfeeding, D vitamin supplementation, iron supplementation, or anemia in childhood. Performing a thorough study of nutritional factors and CVD would need accounting for more confounding factors than was possible within the scope of our study and data.…”

Section: Discussioncontrasting

confidence: 61%

Early Childhood Growth and Risk of Adult Cerebrovascular Disease: The NFBC1966

Kivelä

Paananen

Kajantie

et al. 2022

Stroke

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Background: Low birth weight is associated with an increased risk of adulthood cerebrovascular disease (CVD). Not much is known about effects of early childhood growth. We studied whether the risk of adult CVD is associated with growth or nutritional factors during early childhood. Methods: Within the Northern Finland Birth Cohort 1966, 11 991 persons were followed from birth to 52 years of age. CVD diagnoses were extracted from national hospital and death registers with diagnostic coding based on the World Health Organization recommendations. Cox proportional hazard models were used to estimate associations of childhood growth variables, growth trajectories (by Latent Class Growth Modeling), and nutritional factors with adult CVD, for example, ischemic and hemorrhagic strokes. The analyses were adjusted for childhood socioeconomic status and birth weight. Results: A total of 453 (3.8%) CVDs were recorded during follow-up. Among females, groups with low early childhood weight and height had an increased risk for adulthood ischemic CVDs, with an adjusted hazard ratio of 1.97 (95% CI, 1.21–3.20) and 2.05 (CI, 1.11–3.81), respectively. In addition, females with body mass index over 1 SD at body mass index rebound had an increased risk for ischemic CVDs (adjusted hazard ratio, 1.90 [CI, 1.19–3.04]) compared with females with body mass index −1 to +1 SD. These associations were not found among males. Conclusions: The findings suggest that timing of weight gain during childhood is of significance for development of CVD risk among females.

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Section: Discussioncontrasting

confidence: 61%

Early Childhood Growth and Risk of Adult Cerebrovascular Disease: The NFBC1966

Kivelä

Paananen

Kajantie

et al. 2022

Stroke

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“…Serum 25-hydroxyvitamin D is an important indicator of vitamin D levels. It is associated with human health status, and 25(OH)D levels are negatively associated with all-cause mortality and stroke risk in elderly Chinese [ 11 , 12 ]. Higher levels of 25(OH)D are associated with lower overall cancer risk [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

The establishment of serum 25-hydroxyvitamin D reference intervals in children aged 0–14 years in Zigong area, China

Huang

2021

J Physiol Anthropol

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Objective To establish the reference interval of serum 25-hydroxyvitamin D (25(OH)D) in apparently healthy children in Zigong, China, using an indirect method to provide a basis for proper clinical diagnosis and treatment. Methods A total of 1851 apparently healthy children of the Children’s Health Care Department in Zigong First People’s Hospital between January 2016 and December 2020 were included in the study. The Kolmogorov–Smirnov test was used to analyze the data for normality, and the non-normally distributed data were transformed into approximately normal distribution by Blom's normal rank transformation, and the transformed data were excluded from outliers by the quartile spacing method, and the data were stratified and analyzed according to sex, age, and season. The data were stratified according to sex, age, and season, and the area between the 2.5% and 97.5% percentile points was used as the reference interval. Results The serum 25(OH)D data were non-normally distributed. The data were normally distributed after Blom’s normality rank transformation, and 92 cases of outliers were excluded from the transformed data according to the interquartile spacing method. The differences in serum 25(OH)D levels between sex were not statistically significant (P > 0.05), and there was no need to establish reference intervals based on sex. There was no statistically significant difference in serum 25-hydroxyvitamin D levels between winter and spring, and also no difference between summer and autumn (P > 0.05), and the levels were lower in winter-spring than in summer-autumn. Comparison between age groups showed that there was no statistically significant difference in serum 25(OH)D levels between the < 6 months group and the 6 ~ 11 months group, and between the 6 ~ 9 years group and the 10 ~ 14 years group (P > 0.05); serum 25(OH)D levels decreased with increasing age. There was an interactive effect of season and age group on 25(OH)D levels, and the corresponding reference intervals were established according to different seasons and age groups. In summer and autumn, the reference intervals of serum 25(OH)D for < 1 year, 1 ~ 2 years, 3 ~ 5 years, and 6 ~ 14 years were 39.86 ~ 151.43, 31.54 ~ 131.65, 22.05 ~ 103.75, and 15.36 ~ 85.53 ng/ml and 24.42 ~ 144.20, 31.54 ~ 131.65, 16.80 ~ 165.68, and 15.46 ~ 85.54 ng/ml in winter and spring, respectively. Conclusion Reference intervals for serum 25(OH)D in children of different seasons and ages in Zigong, China, were established to provide a reference for clinical disease diagnosis, treatment, and prognosis determination.

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“…A meta-analysis reported an association between vitamin D deficiency and stroke ( 15 ). Researchers have also presented a potential physiological role of vitamin D in regulating vascular calcification ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin D has a potent role in the regulation of the renin–angiotensin aldosterone system, as well as anti-inflammatory, antioxidative ( 14 ). It has been reported that 25(OH)D level was inversely related to stroke risk, with a non-linear dose response relationship ( 15 ). Previous studies have shown that vitamins D and K have a synergistic effect on cardiovascular health ( 16 , 17 ).…”

Section: Introductionmentioning

confidence: 99%

Joint Association of Low Vitamin K1 and D Status With First Stroke in General Hypertensive Adults: Results From the China Stroke Primary Prevention Trial (CSPPT)

Wei

et al. 2022

Front. Neurol.

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BackgroundVitamin K plays a role in preventing vascular calcification and may have a synergetic influence with vitamin D on cardiovascular health. However, whether this relationship applies to stroke, especially in a high-risk population of hypertensive individuals, remains unclear. The present study aims to study the joint association of low vitamin K1 and D status with first stroke in general hypertensive adults.MethodsThis study used a nested, case–control design with data from the China Stroke Primary Prevention Trial. The analysis included 604 first total stroke patients and 604 matched controls from a Chinese population with hypertension. Odds ratios (ORs) and 95% confidence intervals were calculated using conditional logistic regression.ResultsThere was a non-linear negative association between plasma vitamin K1 and the risk of first total stroke or ischemic stroke in the enalapril-only group. Compared to participants in vitamin K1 quartile 1, a significantly lower risk of total stroke (OR = 0.58, 95% CI: 0.36, 0.91, P = 0.020) or ischemic stroke (OR = 0.34, 95% CI: 0.17, 0.63, P < 0.001) was found in participants in vitamin K1 quartile 2-4 in the enalapril-only group. When further divided into four subgroups by 25(OH)D and vitamin K1, a significantly higher risk of total stroke or ischemic stroke was observed in participants with both low vitamin K1 and 25(OH)D compared to those with both high vitamin K1 and 25(OH)D in the enalapril-only group. No increased risk was observed in the groups low in one vitamin only.ConclusionLow concentrations of both vitamin K1 and 25(OH)D were associated with increased risk of stroke.

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25-Hydroxyvitamin D level, vitamin D intake, and risk of stroke: A dose–response meta-analysis

Cited by 39 publications

References 56 publications

Early Childhood Growth and Risk of Adult Cerebrovascular Disease: The NFBC1966

Early Childhood Growth and Risk of Adult Cerebrovascular Disease: The NFBC1966

The establishment of serum 25-hydroxyvitamin D reference intervals in children aged 0–14 years in Zigong area, China

Joint Association of Low Vitamin K1 and D Status With First Stroke in General Hypertensive Adults: Results From the China Stroke Primary Prevention Trial (CSPPT)

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