25-hydroxyvitamin D is associated with adiposity and cardiometabolic risk factors in a predominantly vitamin D-deficient and overweight/obese but otherwise healthy cohort

Mousa, Aya; Naderpoor, Negar; Courten, Barbora de; Scragg, Robert

doi:10.1016/j.jsbmb.2016.12.008

Cited by 47 publications

(44 citation statements)

References 76 publications

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“…In studies elsewhere, it has been shown that vitamin D deficiency in children may increase the risk of CVD 39. Other reports suggest that associations between vitamin D and cardiometabolic risk among healthy, non-diabetic adults are largely mediated by adiposity 40. Although a gender difference in MetS was not observed in our study, a report based on the 2012 Korean National Health and Nutrition Examination Survey (KNHANES) data indicate that serum 25 (OH)D levels were inversely associated with MetS in men, while it did not show any association with MetS in women 41.…”

Section: Discussioncontrasting

confidence: 85%

Association of Gender-Specific Risk Factors in Metabolic and Cardiovascular Diseases: An NHANES-Based Cross-Sectional Study

Zhang

Cheng

Wang

et al. 2018

Journal of Investigative Medicine

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In the present cross-sectional study, based on National Health and Nutrition Examination Survey (NHANES, 2007-2010) cohorts, various risk factors for metabolic syndrome (MetS) and cardiovascular diseases (CVDs) were analyzed (n=12,153). The variables analyzed include, demographics, comorbidities associated with MetS or CVD, behavioral and dietary factors, while the primary endpoints were the prevalence of MetS and CVD. The prevalence of MetS and CVD was slightly higher in males as compared with females (42.50% and 7.65% vs 41.29% and 4.13%, respectively). After controlling for confounding factors, advanced age, family history of diabetes mellitus (DM), overweight, and obesity were significantly associated with the likelihood of MetS, irrespective of gender differences. In males, the diagnosis of prostate cancer and regular smoking were additional risk factors of MetS, whereas, advanced age, family history of heart attack or angina, health insurance coverage, diagnosis of rheumatoid arthritis or depression, obesity and low calorie intake were identified as risk factors for CVD. In addition to the above risk factors, higher physical activity and vitamin D insufficiency were also found to increase the risk of CVD in females. Furthermore, obesity was a higher risk factor for MetS than CVD. Emerging risk factors for CVD identified in this study has major clinical implications. Of interest is the correlation of higher physical activity and the risk of CVD in women and the role of depression and lower calorie intake in general population.

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Section: Discussioncontrasting

confidence: 85%

Association of Gender-Specific Risk Factors in Metabolic and Cardiovascular Diseases: An NHANES-Based Cross-Sectional Study

Zhang

Cheng

Wang

et al. 2018

Journal of Investigative Medicine

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“…The majority of these cross‐sectional studies showed a positive association of serum 25(OH)D 3 levels with insulin sensitivity measures derived from a hyperinsulinemic euglycemic clamp test or indirect markers such as Matsuda index or quantitative insulin sensitivity index (QUICKI) . A negative association was observed with Homeostatic Model Assessment of Insulin Resistance (HOMA‐IR) or 2‐hour Oral Glucose Tolerance Test (2 h OGTT) . However, in most studies, the relationship between serum 25(OH)D 3 and markers of insulin sensitivity/resistance attenuated or even disappeared after adjustment for markers of adiposity (including BMI and/or body fat percentage).…”

Section: Vitamin D Blood Glucose Control and Insulin Sensitivitymentioning

confidence: 99%

Vitamin D deficiency in the aetiology of obesity‐related insulin resistance

Pramono

Jocken

Blaak

2019

Diabetes Metabolism Res

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The obese insulin-resistant state is often associated with low circulating concentration of vitamin D 25-hydroxyvitamin D 3 [25(OH)D 3 ]. Fat sequestration of vitamin D in the expanded obese adipose tissue mass has been pointed out as a plausible explanation for this circulating vitamin D deficiency. However, the putative mechanisms behind this hypovitaminosis D remain to be elucidated. The presence of vitamin D receptor and vitamin D-metabolizing enzymes in insulin-sensitive organs suggests that vitamin D may be involved in glucose and lipid metabolism and may be related to insulin sensitivity. Indeed, mainly in vitro studies support a role of vitamin D in regulating glucose and lipid metabolism in several insulin-sensitive tissues including adipose tissue, skeletal muscle, liver, as well as pancreatic insulin secretion. A potential role of vitamin D in gut barrier function and metabolism has also been suggested. This review summarizes recent knowledge on vitamin D deficiency in the aetiology of obesity-related insulin resistance and discusses potential underlying mechanisms. Finally, the role of vitamin D supplementation on insulin sensitivity and glycaemic control is discussed.

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“…We previously reported that plasma 25(OH)D was related to insulin sensitivity in a larger study [22]; however, this relationship was not present in the subgroup analysis of participants who underwent skeletal muscle and adipose tissue sampling. Similar to our findings, previous studies using the hyperinsulinemic-euglycemic clamp with similar sample sizes have reported that vitamin D supplementation in both vitamin D-deficient/-insufficient [13] and replete individuals [26] has a modest effect on insulin sensitivity.…”

Section: Discussionmentioning

confidence: 91%

“…This study is a subset of a larger study of 111 healthy normoglycemic adults, where we reported a positive association between plasma 25(OH)D concentration and insulin sensitivity measured by hyperinsulinemic-euglycemic clamp [22]. Due to the invasive nature of skeletal muscle and subcutaneous adipose tissue sampling in humans, the sample size is limited to seventeen adults (ten males and seven females) who had participated in the larger study.…”

Section: Methodsmentioning

confidence: 99%

“…Due to the invasive nature of skeletal muscle and subcutaneous adipose tissue sampling in humans, the sample size is limited to seventeen adults (ten males and seven females) who had participated in the larger study. Detailed methodology for medical pre-screening, insulin sensitivity and protein analysis have previously been reported [22]. In brief, biopsies of subcutaneous adipose and vastus lateralis muscle were performed at rest prior to the hyperinsulinemic-euglycemic clamp after a 12 h overnight fast, under local anesthesia, and using standard aseptic techniques.…”

Section: Methodsmentioning

confidence: 99%

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Plasma 25-Hydroxyvitamin D Is Related to Protein Signaling Involved in Glucose Homeostasis in a Tissue-Specific Manner

et al. 2016

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Vitamin D has been suggested to play a role in glucose metabolism. However, previous findings are contradictory and mechanistic pathways remain unclear. We examined the relationship between plasma 25-hydroxyvitamin D (25(OH)D), insulin sensitivity, and insulin signaling in skeletal muscle and adipose tissue. Seventeen healthy adults (Body mass index: 26 ± 4; Age: 30 ± 12 years) underwent a hyperinsulinemic-euglycemic clamp, and resting skeletal muscle and adipose tissue biopsies. In this cohort, the plasma 25(OH)D concentration was not associated with insulin sensitivity (r = 0.19, p = 0.56). However, higher plasma 25(OH)D concentrations correlated with lower phosphorylation of glycogen synthase kinase-3 (GSK-3) αSer21 and βSer9 in skeletal muscle (r = −0.66, p = 0.015 and r = −0.53, p = 0.06, respectively) and higher GSK-3 αSer21 and βSer9 phosphorylation in adipose tissue (r = 0.82, p < 0.01 and r = 0.62, p = 0.042, respectively). Furthermore, higher plasma 25(OH)D concentrations were associated with greater phosphorylation of both protein kinase-B (AktSer473) (r = 0.78, p < 0.001) and insulin receptor substrate-1 (IRS-1Ser312) (r = 0.71, p = 0.01) in adipose tissue. No associations were found between plasma 25(OH)D concentration and IRS-1Tyr612 phosphorylation in skeletal muscle and adipose tissue. The divergent findings between muscle and adipose tissue with regard to the association between 25(OH)D and insulin signaling proteins may suggest a tissue-specific interaction with varying effects on glucose homeostasis. Further research is required to elucidate the physiological relevance of 25(OH)D in each tissue.

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25-hydroxyvitamin D is associated with adiposity and cardiometabolic risk factors in a predominantly vitamin D-deficient and overweight/obese but otherwise healthy cohort

Cited by 47 publications

References 76 publications

Association of Gender-Specific Risk Factors in Metabolic and Cardiovascular Diseases: An NHANES-Based Cross-Sectional Study

Association of Gender-Specific Risk Factors in Metabolic and Cardiovascular Diseases: An NHANES-Based Cross-Sectional Study

Vitamin D deficiency in the aetiology of obesity‐related insulin resistance

Plasma 25-Hydroxyvitamin D Is Related to Protein Signaling Involved in Glucose Homeostasis in a Tissue-Specific Manner

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