25-Hydroxyvitamin D in Patients With Melanoma and Factors Associated With Inadequate Levels

Hernández-Ostiz, S.; Pérez-Ramada, M.D.; Murillo-Ortíz, Blanca; Requena, Celia; Ribas, G.; Aznar, Eduardo Orduña; Nagore, Eduardo

doi:10.1016/j.adengl.2016.06.021

Cited by 4 publications

(6 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rodríguez-Rodríguez et al (2011) analyzed the vitamin D status of 103 schoolchildren, of whom 51% presented vitamin D deficiency. In Valencia, in a study with 215 patients with melanoma, Hernández-Ostiz et al (2016) found that 66.5% of the patients had insufficient levels over a period of a year. In a study on a larger sample (1262 participants) over one year, Gonzalez Molero et al…”

Section: Introductionmentioning

confidence: 98%

“…Although Spain receives many hours of sunshine every year, a number of studies have found that a high percentage of various groups of the Spanish population suffer from vitamin D deficiency (Cutillas-Marco et al, 2013;Galán et al, 2011;González Molero et al, 2011;Hernández-Ostiz et al, 2016;Mata-Granados et al, 2008;Rodríguez-Rodríguez et al, 2011;Rodríguez-Sangrador et al, 2008). Recent observational studies defined vitamin D deficiency as a 25(OH)D serum level of nmol/L or less, vitamin D sufficiency as 75 nmol/L or higher and vitamin D insufficiency from 50 to 75 nmol/L (Cashman et al, 2016;Garland et.…”

Section: Introductionmentioning

confidence: 99%

“…This deficiency in the Spanish population could be due to insufficient exposure to the sun from the use of high-factor sunscreens in summer and warm clothing in winter. Other factors to be taken into account are the age of the individuals, a dark skin pigmentation, and obesity (Binkley et al, 2007;Godar et al, 2011;Hernández-Ostiz et al, 2016;Holick, 2004Holick, , 2005Holick, , 2007Ovesen et al, 2003). Some studies also found that the vitamin D content in the Spanish diet was insufficient and concluded that the Spanish population had an inadequate intake (Gonzalez-Rodríguez et al, 2013;Ortega et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Contribution of sun exposure to the vitamin D dose received by various groups of the Spanish population

Serrano

2018

Science of The Total Environment

View full text Add to dashboard Cite

Although the harmful effects of excessive exposure to solar ultraviolet (UV) radiation are well known, the recommended dose of UV radiation is beneficial for the synthesis of vitamin D by the skin, in addition to being useful in the treatment of various illnesses and mental problems. Numerous studies have shown that vitamin D performs important functions in the human organism, such as absorbing calcium and phosphorous and contributing to the immune system, among others. Several studies have found that a high percentage of various groups of the Spanish population suffer from vitamin D deficiency, and since very few natural foods contain vitamin D, it was considered important to determine whether groups such as schoolchildren, outdoor workers and athletes, receive enough solar radiation to produce adequate levels of vitamin D in their daily activities. It was found that the amount of vitamin D (in IU) produced by personal effective solar UV doses could exceed the recommended dose of 1000IU/day in spring and summer, while the winter estimate (about 220IU/day) is only one quarter of the recommended dose. These results suggest that most people would not receive the recommended daily vitamin D dose in winter from exposure to solar UV radiation, the main source of vitamin D.

show abstract

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Contribution of sun exposure to the vitamin D dose received by various groups of the Spanish population

Serrano

2018

Science of The Total Environment

View full text Add to dashboard Cite

show abstract

“…Our results are in line with the results found in previous studies from the same geographical area, including other populations at risk of hypovitaminosis D owing to extreme sun avoidance, such as patients diagnosed with melanoma. 18,19 Almost 9% of these patients showed deficient calcidiol levels during followup and only 25% had sufficient levels, especially with blood sampling taken in autumn/winter. 18 Moreover, in central Spain (Madrid, latitude 40°26 0 ), 38% of KTRs had a deficiency (< 16 ng/mL) and 47% had an insufficiency (16-30 ng/mL) in 25(OH)D 3 levels.…”

Section: Discussionmentioning

confidence: 99%

“…18,19 Almost 9% of these patients showed deficient calcidiol levels during followup and only 25% had sufficient levels, especially with blood sampling taken in autumn/winter. 18 Moreover, in central Spain (Madrid, latitude 40°26 0 ), 38% of KTRs had a deficiency (< 16 ng/mL) and 47% had an insufficiency (16-30 ng/mL) in 25(OH)D 3 levels. 20 Similarly, in Israel (latitude 31°47 0 , Mediterranean climate), 22% of KTRs and 21% of LTRs had deficient calcidiol levels, and around 75% of the sample had some degree of hypovitaminosis D. 21 This means that even in a Mediterranean climate, with relatively high sun exposure, the prevalence of some degree of vitamin D deficiency involves more than two-thirds of patients in populations at risk.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency in solid‐organ transplant recipients from a Spanish Mediterranean population

et al. 2019

View full text Add to dashboard Cite

Summary Background Solid‐organ transplant recipients (SOTRs) are at risk of developing vitamin D deficiency, mainly caused by reduced sunlight exposure with subsequent low vitamin D synthesis in the skin. Aim To analyse whether SOTRs from a Spanish Mediterranean region were vitamin D‐deficient. Methods This was a cross‐sectional, descriptive and observational study in a transplantation‐specialized Dermatological Unit from a Mediterranean area to determine the calcidiol levels of a cohort of 78 consecutively attending patients not receiving vitamin D supplements. Serum 25(OH)D3 levels were determined and clinical characteristics were collected. Logistic regression analysis was used to analyse variables associated with dichotomized 25(OH)D3 levels (≤ or > 10 ng/mL). Results The cohort comprised 30 lung, 29 kidney and 19 liver transplant recipients. Mean calcidiol was 18 ± 9 ng/mL. Deficiency of 25(OH)D3 was present in 19% of patients, while 68% had insufficient levels and 13% had sufficient levels. Following multivariate logistic regression analysis, the season of blood sampling remained the only predictor of deficient 25(OH)D3 levels. Conclusion Despite living in a mid‐latitude country with sunny weather, our SOTR population was at high risk of developing hypovitaminosis D, especially in autumn/winter. Avoiding sun exposure is important to prevent skin cancer, but careful monitoring of vitamin D status is recommended, with supplementation if hypovitaminosis D is detected.

show abstract

Vitamin D levels in a cohort of Portuguese melanoma patients relate to time of follow-up from diagnosis, sun-exposure behaviour, and use of photoprotection

2018

View full text Add to dashboard Cite

25-Hydroxyvitamin D in Patients With Melanoma and Factors Associated With Inadequate Levels

Cited by 4 publications

References 33 publications

Contribution of sun exposure to the vitamin D dose received by various groups of the Spanish population

Contribution of sun exposure to the vitamin D dose received by various groups of the Spanish population

Vitamin D deficiency in solid‐organ transplant recipients from a Spanish Mediterranean population

Vitamin D levels in a cohort of Portuguese melanoma patients relate to time of follow-up from diagnosis, sun-exposure behaviour, and use of photoprotection

Contact Info

Product

Resources

About