25-Hydroxyvitamin D in cerebrospinal fluid during relapse and remission of multiple sclerosis

Holmøy, Trygve; Moen, Stine Marit; Gundersen, Thomas A; Holick, Michael F.; Fainardi, Enrico; Castellazzi, Massimiliano; Casetta, Ilaria

doi:10.1177/1352458509107008

Cited by 79 publications

(52 citation statements)

References 15 publications

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“…Jugdeep et al [36] found no significant changes in the SF-36 scores of subjects who received a single intramuscular injection of 600 000 IU ergocalciferol, whereas a different study demonstrated an improvement in seasonal affective disorder as a result of vitamin D supplementation [37] . In our study, there were significant decreases in PF, VT, SF, and MF scores on the SF-36 at the 12- [38] . In situ, vitamin D exerts its effects via vitamin D receptors, which are nuclear hormone receptors that are expressed in cerebral neurons.…”

Section: Discussionsupporting

confidence: 54%

Physical performance and life quality in postmenopausal women supplemented with vitamin D: a two-year prospective study

et al. 2015

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Aim: To investigate the effects of calcium and vitamin D supplementation on bone turnover marker levels, muscle strength and quality of life in postmenopausal Chinese women. Methods: A total of 485 healthy postmenopausal Chinese women (63.44±5.04 years) were enrolled in this open-label, 2-year, prospective, community-based trial. The participants were divided into group A, B, C, which were treated with calcium (600 mg/d) alone, calcium (600 mg/d) and cholecalciferol (800 IU/d) or calcium (600 mg/d) and calcitriol (0.25 μg/d), respectively, for 2 years. Serum levels of 25-hydroxyvitamin D, parathyroid hormone, β-CTX and P1NP were measured, and the muscle strength and quality of life were assessed at baseline and at 12-and 24-month follow-ups. Results: Four hundred and sixty one participants completed this study. Serum levels of 25-hydroxyvitamin D were significantly increased in group C, but not changed in groups A and B at 24-month follow-up. Serum levels of parathyroid hormone, bone turnover marker β-CTX and bone formation marker P1NP were significantly decreased in group C, while serum levels of β-CTX were increased in group A at 24-month follow-up. The participants in group C maintained the grip strength, while those in groups A and B exhibited decreased grip strength at 24-month follow-up. The quality of life for the participants in groups B and C remained consistent, but that in group A was deteriorated at 24-month follow-up. Conclusion: Supplementation with calcitriol and calcium modifies the bone turnover marker levels, and maintains muscle strength and quality of life in postmenopausal Chinese women, whereas supplementation with cholecalciferol and calcium prevents aging-mediated deterioration in quality of life.

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Section: Discussionsupporting

confidence: 54%

Physical performance and life quality in postmenopausal women supplemented with vitamin D: a two-year prospective study

et al. 2015

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“…A Norwegian study failed to detect an inverse correlation between serum 25(OH)D levels and MS disease activity [90]. This study was the first to quantify and compare the 25(OH)D and 1,25(OH) 2 …”

Section: Vitamin D In Relapsingeremitting Multiple Sclerosismentioning

confidence: 97%

Vitamin D and Multiple Sclerosis

Hayes¹,

Nashold²,

Mayne³

et al. 2011

Vitamin D

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“…However, they could not find any significant difference between the levels of the biologically active vitamin D metabolite, 1,25(OH)D in MS patients and controls as well as no association with relapse or gadolinium-enhanced lesions was determined [76].…”

Section: Vitamin Dmentioning

confidence: 99%

Environmental triggers of multiple sclerosis

Kakalacheva

Lünemann

2011

FEBS Letters

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a b s t r a c tMultiple sclerosis is a chronic immune-mediated disease of the central nervous system that develops in young adults with a complex genetic predisposition. Similar to other autoimmune disease, HLA-DR and -DQ alleles within the HLA class II region on chromosome 6p21 are by far the strongest risk-conferring genes. Less robust susceptibility effects have been reported for non-MHC related genetic variants. Improvements in the design of epidemiological studies helped to identify consistent environmental risk-associations such as the increased susceptibility for MS in individuals with a history of infectious mononucleosis, a symptomatic primary infection with the human c-herpesvirus Epstein-Barr virus (EBV). Sun exposure and serum vitamin D levels are emerging non-infectious environmental risk factors that may have independent roles. The analysis of environmental effects will likely expand in the next few years and will allow for the generation of testable hypotheses as to how environmental insults interact with genetic factors to jointly determine the susceptibility to MS. Insights gained from these studies might facilitate the development of prevention strategies and more effective treatments for MS.

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25-Hydroxyvitamin D in cerebrospinal fluid during relapse and remission of multiple sclerosis

Cited by 79 publications

References 15 publications

Physical performance and life quality in postmenopausal women supplemented with vitamin D: a two-year prospective study

Physical performance and life quality in postmenopausal women supplemented with vitamin D: a two-year prospective study

Vitamin D and Multiple Sclerosis

Environmental triggers of multiple sclerosis

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