25-Hydroxyvitamin D and metabolic-related laboratory values in women with schizophrenia and hyperprolactinemia

Nallani, Madhulika C; Powell, Megan; Pugh, Sharon L.; Kearns, Ann Marie; Adams, Heather; Weiner, Elaine; Wehring, Heidi J.; McEvoy, Joseph P.; Buckley, Peter F.; Liu, Fang; Boyer, Robert; Kelly, Deanna L.

doi:10.1016/j.jpsychires.2022.03.046

Cited by 1 publication

(5 citation statements)

References 31 publications

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“…Training to recognize sex-specific prodromal signs [26,27] High prevalence of childhood adversities in schizophrenia women…”

Section: Prodromal Signs Of Psychosis Differ Between Men and Womenmentioning

confidence: 99%

“…Careful history taking and early intervention [26] Early phases of disorder Negative influence of hyperprolactinemia on cognition Screening, prevention, and monitoring of hyperprolactinemia [27,28] Sexual dysfunction Sexual health interventions [29] Abortion and sexual violence Psychoeducation, family planning [30][31][32][33][34][35] Sexual and reproductive health…”

Section: Prodromal Signs Of Psychosis Differ Between Men and Womenmentioning

confidence: 99%

“…Women who present with delusional ideas and report hearing voices but are cognitively intact and show appropriate affect and few negative symptoms (apathy, social avoidance), need careful monitoring for schizophrenia. Brand and collaborators [26] recommend physician education on male/female divergence in these respects. A second recommendation is a routine exploration of childhood adverse events in women.…”

Section: Prodromal Signs Of Psychosis Differ Between Men and Womenmentioning

confidence: 99%

“…A third recommendation is an inquiry into symptom fluctuation over the menstrual month. Premenstrual increase in psychotic symptom severity can be addressed by a slight dose increase of antipsychotic drugs over the three-day period preceding menses [26].…”

Section: Prodromal Signs Of Psychosis Differ Between Men and Womenmentioning

confidence: 99%

“…High prolactin levels reduce fertility. Yu and collaborators [29] asked about reproductive concerns in 15 women with schizophrenia (age [26][27][28][29][30][31][32][33][34][35][36][37][38][39][40]. The women's main concerns were psychological barriers to reproduction such as discouragement by their partners and by medical/psychiatric staff.…”

Section: Reproductive Health At the Early Stages Of Illnessmentioning

confidence: 99%

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Improving treatment of women with schizophrenia: a review of the recent literature

González-Rodríguez,

Cobo,

Seeman

2023

Exploration of Medicine

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Effective clinical management of women with schizophrenia is therapeutically challenging. While there have been recent advances in the understanding of neurobiological, hormonal, and female reproductive cycle factors that play a decisive role in the development and progression of schizophrenia in women, this knowledge has not yet been fully translated into treatment practice. The aim was to apply the best evidence available to optimally treat women with schizophrenia at various periods of the lifespan. A narrative review was conducted of recent advances (2018–2023) in aspects of schizophrenia in women that demand sex-specific treatment. Sex steroids impact antipsychotic absorption, distribution, metabolism, elimination, passage through the blood-brain barrier, and blood flow rate to the brain. For these reasons, premenopausal women with schizophrenia, as compared to male age peers, require lower doses of most antipsychotic drugs and suffer comparatively more adverse events (metabolic, sexual, and cardiovascular) at similar doses. Apart from pharmacologic treatment, women have specific reproductive planning needs and need protection from sexual exploitation and domestic abuse. In addition, when pregnant, schizophrenia women show a high risk of gestational diabetes and pre-eclampsia/eclampsia that requires prevention. Prevention is also needed against long-term health hazards for their offspring. Another period of therapeutic challenge specific to women is menopause. The collected evidence points to women-specific recommendations for both biological and psychosocial treatment strategies for schizophrenia.

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“…Training to recognize sex-specific prodromal signs [26,27] High prevalence of childhood adversities in schizophrenia women…”

Section: Prodromal Signs Of Psychosis Differ Between Men and Womenmentioning

confidence: 99%

Section: Prodromal Signs Of Psychosis Differ Between Men and Womenmentioning

confidence: 99%

Section: Prodromal Signs Of Psychosis Differ Between Men and Womenmentioning

confidence: 99%

Section: Prodromal Signs Of Psychosis Differ Between Men and Womenmentioning

confidence: 99%

Section: Reproductive Health At the Early Stages Of Illnessmentioning

confidence: 99%

See 3 more Smart Citations

Improving treatment of women with schizophrenia: a review of the recent literature

González-Rodríguez,

Cobo,

Seeman

2023

Exploration of Medicine

View full text Add to dashboard Cite

show abstract

25-Hydroxyvitamin D and metabolic-related laboratory values in women with schizophrenia and hyperprolactinemia

Cited by 1 publication

References 31 publications

Improving treatment of women with schizophrenia: a review of the recent literature

Improving treatment of women with schizophrenia: a review of the recent literature

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