25-hydroxycholesterol: Gatekeeper of intestinal IgA

Piper, Christopher; Mauri, Claudia

doi:10.1016/j.immuni.2021.09.017

Cited by 3 publications

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As shown in Figure 1A, 25-hydroxycholesterol (25-HC) is formed through hydroxylation at the 25 th carbon of cholesterol by cholesterol-25-hydroxylase (CH25H) (12). According to recent studies, 25-HC regulates various physiological functions, including homeostasis of lipid metabolism, antiviral effects, inflammation, survival, apoptosis, and autophagy (13)(14)(15).…”

Section: -Hydroxycholesterol-induced Osteoblast Oxiapoptophagy Is Inv...mentioning

confidence: 99%

25-Hydroxycholesterol-induced Osteoblast Oxiapoptophagy Is Involved in the Pathophysiological Process of Osteoporosis

Seo

Kang

Lim

et al. 2023

In Vivo

View full text Add to dashboard Cite

plays important roles in lipid metabolism, inflammatory responses, and apoptosis, but its pathophysiological association with osteoporosis (OP) has not been verified in osteoblasts. Hence, we studied the pathophysiological linkage and underlying cellular mechanisms of 25-HC in human osteoblast-like MG-63 cells and an ovariectomyinduced osteoporotic mouse model. Materials and Methods: To investigate the pathophysiological linkage between 25-HC-induced osteoblast oxiapoptophagy and OP, 25-HC ELISA assay, MTT assay, cell live/dead staining, hematoxylin and eosin staining, DAPI staining, flow cytometry analysis, western blot, caspase-3 staining, reactive oxygen species (ROS) assay, autophagy staining, immunocytochemistry, Micro-CT image analysis and immunocytochemistry were performed in MG-63 cells and ovariectomy-induced OP animals. Results: The expression of cholesterol-25hydroxylase (CH25H), an enzyme catalyzing the conversion of cholesterol to 25-HC, and the production of 25-HC were increased by lipopolysaccharide in MG-63 cells. Cytotoxicity was increased by 25-HC in MG-63 cells. Apoptosis with condensed chromatin and altered morphology was induced by 25-HC through cleavage of

show abstract

Section: -Hydroxycholesterol-induced Osteoblast Oxiapoptophagy Is Inv...mentioning

confidence: 99%

25-Hydroxycholesterol-induced Osteoblast Oxiapoptophagy Is Involved in the Pathophysiological Process of Osteoporosis

Seo

Kang

Lim

et al. 2023

In Vivo

View full text Add to dashboard Cite

show abstract

“…The lack of IgA in DIO mice led to changes in the intestinal microbiome, which could be transferred to antibiotics-treated (microbiota-depleted) obese wild-type mice through faecal transplantation. Notably, it has also been demonstrated that oxysterol metabolism is impacted in HFD-fed mice [66], and that this leads to alterations in the differentiation of IgA ASCs within gut-associated lymphoid tissue [67,68]. More specifically, Trindade et al demonstrated that levels of the oxysterol 25-hydroxysterol were increased within the Peyer's patches of HFD-versus standard chow-fed mice [67].…”

Section: Potential Mechanisms-molecular Switches That Could Underlie ...mentioning

confidence: 99%

B cell contribution to immunometabolic dysfunction and impaired immune responses in obesity

Oļeiņika

Šlisere

Catalán

et al. 2022

Clinical and Experimental Immunology

View full text Add to dashboard Cite

Obesity increases the risk of type 2 diabetes mellitus, cardiovascular disease, fatty liver disease, and cancer. It is also linked with more severe complications from infections, including COVID-19, and poor vaccine responses. Chronic, low-grade inflammation and associated immune perturbations play an important role in determining morbidity in people living with obesity. The contribution of B cells to immune dysregulation and meta-inflammation associated with obesity has been documented by studies over the past decade. With a focus on human studies, here we consolidate the observations demonstrating that there is altered B cell subset composition, differentiation, and function both systemically and in the adipose tissue of individuals living with obesity. Finally, we discuss the potential factors that drive B cell dysfunction in obesity and propose a model by which altered B cell subset composition in obesity underlies dysfunctional B cell responses to novel pathogens.

show abstract

Implication of Oxysterols and Phytosterols in Aging and Human Diseases

Vigne,

Pot

2023

Implication of Oxysterols and Phytosterols in Aging and Human Diseases

View full text Add to dashboard Cite

25-hydroxycholesterol: Gatekeeper of intestinal IgA

Cited by 3 publications

References 10 publications

25-Hydroxycholesterol-induced Osteoblast Oxiapoptophagy Is Involved in the Pathophysiological Process of Osteoporosis

25-Hydroxycholesterol-induced Osteoblast Oxiapoptophagy Is Involved in the Pathophysiological Process of Osteoporosis

B cell contribution to immunometabolic dysfunction and impaired immune responses in obesity

Implication of Oxysterols and Phytosterols in Aging and Human Diseases

Contact Info

Product

Resources

About