25-Hydroxy vitamin D level is associated with sleep disturbances in patients with chronic kidney disease on hemodialysis: a cross-sectional study

Yavuz, Demet; Demirağ, Mehmet Derya; Yavuz, Rahman; ÖZEN, Düriye Sıla KARAGÖZ; Ramazanoğlu, Zeynep Banu

doi:10.3906/sag-1908-87

“…Hon et al and Yavuz et al approved that the levels of 25(OH) D fell down in dialysis patients having sleep disturbances, in comparison with those that do not have sleep disorders (6,15). However, they did not confirm whether the treatment of vitamin D deficiency could affect the quality of sleep.…”

Section: Discussionmentioning

confidence: 97%

“…Deficiency of vitamin D is commonly experienced by patients who undergo dialysis (6,11,12). Several studies reported the relationship of vitamin D deficiency and sleep disorders in non-dialysis (13,14) and dialysis patients (6,15). Also, according to several research works, vitamin D deficiency treatment improves sleep quality in non-dialysis patients (16,17).…”

Section: Introductionmentioning

confidence: 99%

Effect of vitamin D on sleep quality in hemodialysis patients

Zahed

¹

,

Namakchian

²

,

Davoudi

³

et al. 2020

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Introduction: Quality of sleep is among the factors that affect the improvement of life quality. The previous studies showed that 50%-80% of hemodialysis patients experience sleeping disturbances. Additionally, dialysis patients commonly experience vitamin D deficiency. Objectives: We aimed to determine the impact of vitamin D deficiency therapy on sleep quality of hemodialysis patients. Patients and Methods: Thirty hemodialysis patients with 25-hydroxy vitamin D deficiency and Pittsburgh Sleep Quality Index (PSQI) ≥5 were enrolled in this clinical trial. Patients were treated with 50000-unit vitamin D per week for 12 weeks. After treatment, the PSQI score was recalculated for each patient. Results: Nineteen out of 30 patients (63.3%) were men and 11(36.7%) were women, with a mean age of 56.7 ± 14.3 years. The mean of vitamin D level was 18.61 ± 6.32 ng/mL before treatment and 41.14 ± 9.62 ng/mL after the treatment. The mean of PSQI score at the start of study was 9.97 and after treatment with vitamin D3, it was 9.47 (P > 0.05). Conclusion: Treatment of vitamin D deficiency did not have any effect on the sleep quality according to the PSQI score in hemodialysis patients. Trial registration: This randomized controlled trial was registered in the Iranian Registry of Clinical Trials (identifier: IRCT20200223046593N1; https://en.irct.ir/trial/46126, ethical code; IR.SBMU.RETECH.REC.1397.1277).

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“…However, complications caused by hemodialysis, especially sleep disturbance, are often ignored ( 24 ). Studies have shown that there are many factors associated with sleep disturbance in MHD patients, such as gender, diet, depression and serum PTH levels ( 14 , 16 ). In this study, we found that age, Alb and Ca 2+ were independent risk factors for sleep disturbance in MHD patients, and confirmed that age, Alb and anxiety were associated with the severity of sleep disturbance in MHD patients.…”

Section: Discussionmentioning

confidence: 99%

“…A study has found that gender, age, education level, diabetes history, blood phosphorus level and depression are associated with the sleep quality of MHD patients ( 13 ). Another study has confirmed that compared with MHD patients with good sleep, there are more males, lower serum parathyroid hormone (PTH) and 25-hydroxy vitamin D levels, and a higher incidence of depression in patients with poor sleep, while there is no significant difference in age between groups ( 14 ). Although both studies showed that gender and depression were associated with sleep disturbance in MHD patients, there were differences in age.…”

Section: Introductionmentioning

confidence: 97%

Risk factors and prediction model of sleep disturbance in patients with maintenance hemodialysis: A single center study

Xu

¹

,

Miao

²

,

Ni

³

et al. 2022

Front. Neurol.

3

0

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ObjectivesThis study aimed to explore the risk factors and develop a prediction model of sleep disturbance in maintenance hemodialysis (MHD) patients.MethodsIn this study, 193 MHD patients were enrolled and sleep quality was assessed by Pittsburgh Sleep Quality Index. Binary logistic regression analysis was used to explore the risk factors for sleep disturbance in MHD patients, including demographic, clinical and laboratory parameters, and that a prediction model was developed on the basis of risk factors by two-way stepwise regression. The final prediction model is displayed by nomogram and verified internally by bootstrap resampling procedure.ResultsThe prevalence of sleep disturbance and severe sleep disturbance in MHD patients was 63.73 and 26.42%, respectively. Independent risk factors for sleep disturbance in MHD patients included higher 0.1*age (OR = 1.476, 95% CI: 1.103–1.975, P = 0.009), lower albumin (OR = 0.863, 95% CI: 0.771–0.965, P = 0.010), and lower 10*calcium levels (OR = 0.747, 95% CI: 0.615–0.907, P = 0.003). In addition, higher 0.1*age, lower albumin levels, and anxiety were independently associated with severe sleep disturbance in MHD patients. A risk prediction model of sleep disturbance in MHD patients showed that the concordance index after calibration is 0.736, and the calibration curve is approximately distributed along the reference line.ConclusionsOlder age, lower albumin and calcium levels are higher risk factors of sleep disturbance in MHD, and the prediction model for the assessment of sleep disturbance in MHD patients has excellent discrimination and calibration.

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“…It has been shown that 25 (OH) D deficiency is an important risk factor for reducing sleep quality and the result is independent of other factors such as age, gender, depression, and the effect of hemodialysis [ 52 ]. Jean and coworkers showed that a daily dose of 10-30 mg of 25 (OH) D oral supplements completely resolves vitamin D deficiency in HD patients with high safety.…”

Section: Discussionmentioning

confidence: 99%

The Association of Sleep Quality and Vitamin D Levels in Hemodialysis Patients

Hejazian

¹

,

Ahmadian

²

,

Vahed

³

et al. 2021

BioMed Research International

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Background. To date, hemodialysis (HD) is the most common therapy for chronic kidney disease (CKD) patients. However, it causes different complications such as sleep disorders. Sleep regulation is connected to vitamin D; hence, its deficiency might influence the quality and duration of sleep. This study is aimed at evaluating the correlation of sleep quality and vitamin D levels in 80 HD patients. Methods. This cross-sectional study was performed on 80 hemodialysis patients admitted to 29 Bahman hospitals in Tabriz, Iran. Before beginning of dialysis, serum 25 (OH) D levels were assessed among patients and the sleep patterns and sleep quality of patients were accurately calculated by the Pittsburgh sleep quality index (PSQI) standard questionnaire. Results. Our results showed that 22 HD patients (27.5%) had severe sleep disorders. In addition, it was found that serum levels of vitamin D had significant correlation with sleep quality ( r = − 0.341 , p = 0.002 ) in general, even after adjusting confounding factors such as calcium (Ca), phosphate (P), and parathyroid hormone (PTH) level. In poor sleepers ( PSQI ≤ 5 ), a negative correlation was observed between the levels of vitamin D and PSQI score ( r = − 0.397 , p = 0.004 ). PSQI scores in the normal range of PTH ( r = − 0.377 , p = 0.006 ) and in >600 pg/ml of PTH ( r = − 0.675 , p = 0.011 ) had a correlation with vitamin D levels. The level of vitamin D was the single independent predictor of sleep efficiency ( β coefficient = − 0.386 , p = 0.001 ). Conclusion. The present project reported that the positive effect of vitamin D is associated with sleep disorder in HD patients. In future studies, normal levels of Ca and P should be considered along with normal vitamin D levels among the included patients.

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25-Hydroxy vitamin D level is associated with sleep disturbances in patients with chronic kidney disease on hemodialysis: a cross-sectional study

Cited by 4 publications

References 24 publications

Effect of vitamin D on sleep quality in hemodialysis patients

Effect of vitamin D on sleep quality in hemodialysis patients

Risk factors and prediction model of sleep disturbance in patients with maintenance hemodialysis: A single center study

The Association of Sleep Quality and Vitamin D Levels in Hemodialysis Patients

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