Effects of the Mediterranean Diet Supplemented With Coenzyme Q10 on Metabolomic Profiles in Elderly Men and Women

González-Guardia, Lorena; Yubero‐Serrano, Elena M.; Delgado-Lista, Javier; Pérez-Martínez, Pablo; García‐Rios, Antonio; Marı́n, Carmen; Camargo, Antonio; Delgado‐Casado, Nieves; Roche, Helen M.; Pérez-Jiménez, Francisco; Brennan, Lorraine; López‐Miranda, José

doi:10.1093/gerona/glu098

Cited by 58 publications

(36 citation statements)

References 41 publications

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“…The ROC curve for a two-metabolite set (glycine and PAG) outperformed single markers (glycine, PAG, or adenine), highlighting that this set is a promising biomarker that possesses the greatest discriminatory power to predict individual responses to KBR consumption in sedentary overweight/obese adults. Several other studies have supported an association between urinary glycine or PAG levels and status of oxidative stress [47,48,49,50,51,52] or inflammatory stress [52]. Finally, the predictive accuracy of this two-metabolite set was further validated with the LOOCV procedure, because the ROC curve may lead to an overestimation of the AUC if it is constructed using all samples [53].…”

Section: Discussionmentioning

confidence: 99%

Integration of Traditional and Metabolomics Biomarkers Identifies Prognostic Metabolites for Predicting Responsiveness to Nutritional Intervention against Oxidative Stress and Inflammation

et al. 2017

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Various statistical approaches can be applied to integrate traditional and omics biomarkers, allowing the discovery of prognostic markers to classify subjects into poor and good prognosis groups in terms of responses to nutritional interventions. Here, we performed a prototype study to identify metabolites that predict responses to an intervention against oxidative stress and inflammation, using a data set from a randomized controlled trial evaluating Korean black raspberry (KBR) in sedentary overweight/obese subjects. First, a linear mixed-effects model analysis with multiple testing correction showed that four-week consumption of KBR significantly changed oxidized glutathione (GSSG, q = 0.027) level, the ratio of reduced glutathione (GSH) to GSSG (q = 0.039) in erythrocytes, malondialdehyde (MDA, q = 0.006) and interleukin-6 (q = 0.006) levels in plasma, and seventeen NMR metabolites in urine compared with those in the placebo group. A subsequent generalized linear mixed model analysis showed linear correlations between baseline urinary glycine and N-phenylacetylglycine (PAG) and changes in the GSH:GSSG ratio (p = 0.008 and 0.004) as well as between baseline urinary adenine and changes in MDA (p = 0.018). Then, receiver operating characteristic analysis revealed that a two-metabolite set (glycine and PAG) had the strongest prognostic relevance for future interventions against oxidative stress (the area under the curve (AUC) = 0.778). Leave-one-out cross-validation confirmed the accuracy of prediction (AUC = 0.683). The current findings suggest that a higher level of this two-metabolite set at baseline is useful for predicting responders to dietary interventions in subjects with oxidative stress and inflammation, contributing to the emergence of personalized nutrition.

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Section: Discussionmentioning

confidence: 99%

Integration of Traditional and Metabolomics Biomarkers Identifies Prognostic Metabolites for Predicting Responsiveness to Nutritional Intervention against Oxidative Stress and Inflammation

et al. 2017

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“…Mouse studies involving ApoA1 −/− mice demonstrate that addition of CoQ10 improves infarct size to that of a wild-type mouse [213]. Current human studies using CoQ10 in dietary supplements in adults have hint at improved health with an optimal diet [214, 215], and clinical study in children with primary mitochondrial diseases is underway[214, 215]. …”

Section: Mitochondrial Targeted Therapiesmentioning

confidence: 99%

Mitochondrial dysfunction in cardiac aging

Tocchi

Quarles

Basisty

et al. 2015

Biochimica et Biophysica Acta (BBA) - Bioenergetics

119

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Cardiovascular diseases are the leading cause of death in most developed nations. While it has received the least public attention, aging is the dominant risk factor for developing cardiovascular diseases, as the prevalence of cardiovascular diseases increases dramatically with increasing age. Cardiac aging is an intrinsic process that results in impaired cardiac function, along with cellular and molecular changes. Mitochondria play a great role in these processes, as cardiac function is an energetically demanding process. In this review, we examine mitochondrial dysfunction in cardiac aging. Recent research has demonstrated that mitochondrial dysfunction can disrupt morphology, signaling pathways, and protein interactions; conversely, mitochondrial homeostasis is maintained by mechanisms that include fission/fusion, autophagy, and unfolded protein responses. Finally, we describe some of the recent findings in mitochondrial targeted treatments to help meet the challenges of mitochondrial dysfunction in aging.

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“…The emergence of metabolomics is still recent compared to other omics, but its particular features have contributed greatly to its increasing use [ 59 , 110 ]. Currently, there are a growing number of metabolomic studies in the MedDiet field including the PREDIMED study as well as other studies in other populations [ 60 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 ]. Metabolomics is currently used both to investigate markers of dietary intake and biomarkers of disease [ 115 , 116 ].…”

Section: Omic Biomarkers In the Predimed Study And In Other Studiementioning

confidence: 99%

Advances in Integrating Traditional and Omic Biomarkers When Analyzing the Effects of the Mediterranean Diet Intervention in Cardiovascular Prevention

Fitó

Melander

Martínéz

et al. 2016

IJMS

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Intervention with Mediterranean diet (MedDiet) has provided a high level of evidence in primary prevention of cardiovascular events. Besides enhancing protection from classical risk factors, an improvement has also been described in a number of non-classical ones. Benefits have been reported on biomarkers of oxidation, inflammation, cellular adhesion, adipokine production, and pro-thrombotic state. Although the benefits of the MedDiet have been attributed to its richness in antioxidants, the mechanisms by which it exercises its beneficial effects are not well known. It is thought that the integration of omics including genomics, transcriptomics, epigenomics, and metabolomics, into studies analyzing nutrition and cardiovascular diseases will provide new clues regarding these mechanisms. However, omics integration is still in its infancy. Currently, some single-omics analyses have provided valuable data, mostly in the field of genomics. Thus, several gene-diet interactions in determining both intermediate (plasma lipids, etc.) and final cardiovascular phenotypes (stroke, myocardial infarction, etc.) have been reported. However, few studies have analyzed changes in gene expression and, moreover very few have focused on epigenomic or metabolomic biomarkers related to the MedDiet. Nevertheless, these preliminary results can help to better understand the inter-individual differences in cardiovascular risk and dietary response for further applications in personalized nutrition.

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Effects of the Mediterranean Diet Supplemented With Coenzyme Q10 on Metabolomic Profiles in Elderly Men and Women

Cited by 58 publications

References 41 publications

Integration of Traditional and Metabolomics Biomarkers Identifies Prognostic Metabolites for Predicting Responsiveness to Nutritional Intervention against Oxidative Stress and Inflammation

Integration of Traditional and Metabolomics Biomarkers Identifies Prognostic Metabolites for Predicting Responsiveness to Nutritional Intervention against Oxidative Stress and Inflammation

Mitochondrial dysfunction in cardiac aging

Advances in Integrating Traditional and Omic Biomarkers When Analyzing the Effects of the Mediterranean Diet Intervention in Cardiovascular Prevention

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