Cutaneous blastic plasmacytoid dendritic cell neoplasm: successful palliative treatment with oral prednisone in an elderly patient

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematopoietic malignancy mainly affecting elderly patients. Most patients present with asymptomatic skin lesions as the first symptom and has a high frequency of bone marrow involvement. BPDCN is typically characterized by CD4+ and CD 56+ co-expression without common lymphoid or myeloid lineage markers. There is no consensus on the optimal therapeutic strategy for BPDCN. It is highly responsive to chemotherapy but the median event-free survival is very short. Allogeneic stem cell transplantation may improve the prognosis of BPDCN but the rate of relapse is still high. There are no specific targeted agents approved for patients with BPDCN, but advances in the understanding of the pathobiology of BPDCN and the results of early clinical studies have revealed novel targets and potentially effective agents. Novel targeted therapies may improve outcomes for patients with BPDCN in the future.

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Blastic plasmacytoid dendritic cell neoplasm: update on therapy especially novel agents

Wang

Liu

et al. 2018

Ann Hematol

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Prednisone

2015

Reactions Weekly

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Cutaneous blastic plasmacytoid dendritic cell neoplasm: Report of a case and review of the literature

Lin

Kuo

et al. 2017

Dermatologica Sinica

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Cutaneous blastic plasmacytoid dendritic cell neoplasm: successful palliative treatment with oral prednisone in an elderly patient

Cited by 4 publications

References 8 publications

Blastic plasmacytoid dendritic cell neoplasm: update on therapy especially novel agents

Blastic plasmacytoid dendritic cell neoplasm: update on therapy especially novel agents

Prednisone

Cutaneous blastic plasmacytoid dendritic cell neoplasm: Report of a case and review of the literature

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