A Systematic Review for Anti‐Inflammatory Property of Clusiaceae Family: A Preclinical Approach

Melo, Mônica Santos de Souza; Quintans, Jullyana de Souza Siqueira; Araújo, Adriano Antunes de Souza; Duarte, Marcelo Cavalcante; Bonjardim, Leonardo Rigoldi; Nogueira, Paulo César de Lima; Moraes, Valéria Regina de Souza; Araújo-Júnior, João Xavier de; Ribeiro, Êurica Adélia Nogueira; Quintans‐Júnior, Lucindo J.

doi:10.1155/2014/960258

Cited by 27 publications

(17 citation statements)

References 59 publications

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“…A number of them are prenylated compounds, which often contributes to increase their biological activities [17]. Several polyphenols isolated from these families exhibit anti-inflammatory [18] or immunosuppressive [19, 20] activities and some species are used in folk medicine against inflammatory diseases [21]. …”

Section: Introductionmentioning

confidence: 99%

Prenylated Polyphenols from Clusiaceae and Calophyllaceae with Immunomodulatory Activity on Endothelial Cells

et al. 2016

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Endothelial cells (ECs) are key players in inflammation and immune responses involved in numerous pathologies. Although attempts were experimentally undertaken to prevent and control EC activation, drug leads and probes still remain necessary. Natural products (NPs) from Clusiaceous and Calophyllaceous plants were previously reported as potential candidates to prevent endothelial dysfunction. The present study aimed to identify more precisely the molecular scaffolds that could limit EC activation. Here, 13 polyphenols belonging to 5 different chemical types of secondary metabolites (i.e., mammea coumarins, a biflavonoid, a pyranochromanone acid, a polyprenylated polycyclic acylphloroglucinol (PPAP) and two xanthones) were tested on resting and cytokine-activated EC cultures. Quantitative and qualitative changes in the expression of both adhesion molecules (VCAM-1, ICAM-1, E-selectin) and major histocompatibility complex (MHC) molecules have been used to measure their pharmaceutical potential. As a result, we identified 3 mammea coumarins that efficiently reduce (up to >90% at 10 μM) both basal and cytokine-regulated levels of MHC class I, class II, MICA and HLA-E on EC surface. They also prevented VCAM-1 induction upon inflammation. From a structural point of view, our results associate the loss of the free prenyl group substituting mammea coumarins with a reduced cellular cytotoxicity but also an abrogation of their anti-inflammatory potential and a reduction of their immunosuppressive effects. A PPAP, guttiferone J, also triggers a strong immunomodulation but restricted to HLA-E and MHC class II molecules. In conclusion, mammea coumarins with a free prenyl group and the PPAP guttiferone J emerge as NPs able to drastically decrease both VCAM-1 and a set of MHC molecules and to potentially reduce the immunogenicity of the endothelium.

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Section: Introductionmentioning

confidence: 99%

Prenylated Polyphenols from Clusiaceae and Calophyllaceae with Immunomodulatory Activity on Endothelial Cells

et al. 2016

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“…Garcinia gardneriana is very rich in secondary metabolites. Some phytochemical analyses have identified xanthones, steroids, triterpenes, and flavonoids in different parts of the plant [ 14 , 41 , 42 , 43 ], which have been associated with pharmacological effects such as anti-inflammatory, antinociceptive, antibacterial, and antiparasitic activities [ 38 , 58 , 59 , 60 ].…”

Section: Garcinia Species and Bioactive Compounmentioning

confidence: 99%

Medicinal Potential of Garcinia Species and Their Compounds

et al. 2020

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Garcinia is a genus of Clusiaceae, distributed throughout tropical Asia, Africa, New Caledonia, Polynesia, and Brazil. Garcinia plants contain a broad range of biologically active metabolites which, in the last few decades, have received considerable attention due to the chemical compositions of their extracts, with compounds which have been shown to have beneficial effects in several diseases. Our work had the objective of reviewing the benefits of five Garcinia species (G. brasiliensis, G. gardneriana, G. pedunculata, G. cambogia, and G. mangstana). These species provide a rich natural source of bioactive compounds with relevant therapeutic properties and anti-inflammatory effects, such as for the treatment of skin disorders, wounds, pain, and infections, having demonstrated antinociceptive, antioxidant, antitumoral, antifungal, anticancer, antihistaminic, antiulcerogenic, antimicrobial, antiviral, vasodilator, hypolipidemic, hepatoprotective, nephroprotective, and cardioprotective properties. This demonstrates the relevance of the genus as a rich source of compounds with valuable therapeutic properties, with potential use in the prevention and treatment of nontransmissible chronic diseases.

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“…Medicinal plants under the family Clusiaceae are known as sources of a variety of biologically active compounds (Kuete et al 2013). Some members of this family were reported to have notable ethnopharmacological uses and applications (Acuña et al 2009;De Melo et al 2014;Dapar et al 2020a, b) particularly under the genus Garcinia L. (DeFilipps and Krupnick 2018).…”

Section: Phytochemistrymentioning

confidence: 99%

Garcinia mangostana L. Clusiaceae

Dapar¹

2020

Ethnobotany of Mountain Regions

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often opposite, glabrous, quadrangular, latex usually resinous, thick, yellow in bark, branches, and fruits. Wood brick-red, heavy; bark black or dark brown, yellow, smooth; latex yellow, sticky; latex yellow, sticky. Leaves simple, opposite, lanceolate to elliptic-oblong, about 10-25 Â 4-10 cm across, base acute, margins entire, apex shallow acuminate to acute, glossy, shining, thick, coriaceous, glabrous on both sides, midrib prominent above and beneath, lateral veins 35-50, irregular with oblique parallel short veins, anastomosing near the margins, veinlets reticulate, petiole robust, slender with raised margins, about 1-2.5 cm long, exstipulate. Inflorescence axillary, solitary, or supra axillary cymes. Flowers heterochlamydeous, dioecious, pseudobisexual, fragrant, pedicels about 8-12 mm long. Male flowers rare, axillary, solitary or fascicled with 2-9 flowers, rose pink, sepals 4-5, imbricate, usually persistent in fruit, petals 4-5, imbricate, obovate-orbicular, alternating with sepals, stamens 16 or more in 4 bundles, inserted around lobed mass often around a rudimentary pistil, free or connate at the base, filaments short, anthers peltate, bent at ends, 2 loculed, dehiscing by longitudinal slits. Female flowers often solitary or paired, bigger than male flowers, globose, with minute free or united staminodes, filaments arranged in a ring shape, ovary superior, globose, 4-8 locular, ovules lateral, or erect, style absent, stigma rays 5-6. Fruit fleshy berry (Fig. 2), globose, 4-7 Â 3-6 cm across smooth, reddish-brown or purplish red, glossy, smooth, encased by persistent sepals and crowned by stigma; pericarp thick, spongy, reddish abounding in yellow latex. Seeds 4-8, ca. 1-2 cm long, oblong ovoid, covered with thick, juicy, creamy-white, pleasant-smelling aril. Phenology: Fruiting season vary depending upon geographical location and growing conditions (MBG 2020). Flowering and fruiting are observed during summer or

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A Systematic Review for Anti‐Inflammatory Property of Clusiaceae Family: A Preclinical Approach

Cited by 27 publications

References 59 publications

Prenylated Polyphenols from Clusiaceae and Calophyllaceae with Immunomodulatory Activity on Endothelial Cells

Prenylated Polyphenols from Clusiaceae and Calophyllaceae with Immunomodulatory Activity on Endothelial Cells

Medicinal Potential of Garcinia Species and Their Compounds

Garcinia mangostana L. Clusiaceae

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