The pathophysiology of symptomatic propriospinal myoclonus

Esposito, Marcello; Erro, Roberto; Edwards, Mark J.; Cawley, Niamh; Choi, David; Bhatia, Kailash P.; Cordivari, Carla

doi:10.1002/mds.25951

Cited by 20 publications

(14 citation statements)

References 17 publications

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“…This has followed the realization that many cases of suspected propriospinal myoclonus are certainly psychogenic. 2,[6][7][8] This is evidenced by clinical features, but also confirmed by the presence of a Bereitschafts potential that starts before spontaneous jerks and is similar to that seen preceding voluntary movements. [6][7][8] At the same time, the diagnostic value of a slow spinal recruitment order has been questioned as evidence of organicity, because a similar pattern can occur when young healthy subjects are trained to mimic jerks 9 or in some patients with suspected psychogenic jerks.…”

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confidence: 83%

“…2 No cases were found in their survey of 85 patients with such pathological conditions. But rarity is neither unfamiliar to the neurologist nor an argument for functional causes.…”

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confidence: 85%

“…7,8 But will there be any cases left to be considered idiopathic? Esposito et al 2 imply not. Nevertheless, if we acknowledge that symptomatic propriospinal myoclonus exists, although it is rare, it seems perverse not to allow for the existence of cases in which a symptomatic cause may be yet to declare itself.…”

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confidence: 94%

“…2 Amongst these cases was a patient who presented after excision of a cervical hemangioblastoma, was found to have dural adhesions distorting the cord at the site of former surgery, and improved within days of these adhesions being severed. 1 Perhaps the authors suspected that this patient had a functional movement disorder because "there was no clear correspondence between imaging and neurophysiological findings."…”

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confidence: 97%

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Propriospinal myoclonus: Where do we go from here?

Brown

2014

Movement Disorders

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Propriospinal myoclonus was first described in 1991 as axial jerks of spinal origin.1 The myoclonus differed from segmental spinal myoclonus in that many spinal segments were involved, putatively linked by activity in the axially focused propriospinal pathways that link distant spinal segments within the cord. As such, two additional key features of the myoclonus were that it spared the distal limbs and face, and that myotomes were recruited into the jerks from a spinal focus with relative latencies that were consistent with conduction in slow propriospinal pathways. This original description of propriospinal myoclonus was followed by a gamut of anecdotal and rather speculative reports relating this condition to diverse causes ranging from vitamin deficiency to cannabis exposure.2 These dominated over a steady trickle of more credible reports of propriospinal myoclonus related to causes already associated with spinal segmental myoclonus, such as spinal tumors, syringomyelia, spinal dural arteriovenous fistula, and infective myelitis.

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confidence: 83%

“…2 No cases were found in their survey of 85 patients with such pathological conditions. But rarity is neither unfamiliar to the neurologist nor an argument for functional causes.…”

mentioning

confidence: 85%

mentioning

confidence: 94%

mentioning

confidence: 97%

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Propriospinal myoclonus: Where do we go from here?

Brown

2014

Movement Disorders

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“…6 Bupropion not only enhances dopaminergic and noradrenergic activity by blocking receptor reuptake, but also suppresses the transport of signals across the synapse in both sympathetic and parasympathetic pathways by antagonizing nicotinic-type acetylcholine receptors. 2 One possible explanation is that bupropion-induced disturbance of autonomic ganglia signals might contribute to intractable nausea and vomiting, resulting in PSM.…”

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confidence: 99%