Injectable Microbeads with a Thermo‐Responsive Shell and a pH‐Responsive Core as a Dual‐Switch‐Controlled Release System

Chiang, Wei-Lun; Hu, Yichen; Liu, Hung‐Yi; Hsiao, Chun-Wen; Sureshbabu, Radhakrishnan; Yang, Chih-Man; Chung, Min‐Fan; Chia, Wei-Tso; Sung, Hsing‐Wen

doi:10.1002/smll.201400842

Cited by 15 publications

(5 citation statements)

References 28 publications

(16 reference statements)

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“…This PVO was molecularly modified to release vanillin in acidic pH and presence of H 2 O 2 to treat ROS-related inflammatory diseases [134]. Vancomycin is used as an inflammatory therapeutic drug which is responsive to dual stimuli of temperature and pH [135]. Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease which can affect the entire GI tract.…”

Section: Inflammatory Diseasementioning

confidence: 99%

Responsive Nanostructure for Targeted Drug Delivery

Pawar

Maske

Khan

et al. 2023

JNT

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Currently, intelligent, responsive biomaterials have been widely explored, considering the fact that responsive biomaterials provide controlled and predictable results in various biomedical systems. Responsive nanostructures undergo reversible or irreversible changes in the presence of a stimulus, and that stimuli can be temperature, a magnetic field, ultrasound, pH, humidity, pressure, light, electric field, etc. Different types of stimuli being used in drug delivery shall be explained here. Recent research progress in the design, development and applications of biomaterials comprising responsive nanostructures is also described here. More emphasis will be given on the various nanostructures explored for the smart stimuli responsive drug delivery at the target site such as wound healing, cancer therapy, inflammation, and pain management in order to achieve the improved efficacy and sustainability with the lowest side effects. However, it is still a big challenge to develop well-defined responsive nanostructures with ordered output; thus, challenges faced during the design and development of these nanostructures shall also be included in this article. Clinical perspectives and applicability of the responsive nanostructures in the targeted drug delivery shall be discussed here.

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Section: Inflammatory Diseasementioning

confidence: 99%

Responsive Nanostructure for Targeted Drug Delivery

Pawar

Maske

Khan

et al. 2023

JNT

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“…Vancomycin was loaded in the nanoparticles as the inflammatory therapeutic drug. This dual stimuli-responsive drug MBs could release the drug only in the presence of both stimuli (temperature and pH), preventing unexpected drug release due to accidental stimulus [ 239 ].…”

Section: Applications Of Stimulus-responsive Systemsmentioning

confidence: 99%

Stimulus-Responsive Nanomedicines for Disease Diagnosis and Treatment

Liu

Lovell

Zhang

et al. 2020

IJMS

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Stimulus-responsive drug delivery systems generally aim to release the active pharmaceutical ingredient (API) in response to specific conditions and have recently been explored for disease treatments. These approaches can also be extended to molecular imaging to report on disease diagnosis and management. The stimuli used for activation are based on differences between the environment of the diseased or targeted sites, and normal tissues. Endogenous stimuli include pH, redox reactions, enzymatic activity, temperature and others. Exogenous site-specific stimuli include the use of magnetic fields, light, ultrasound and others. These endogenous or exogenous stimuli lead to structural changes or cleavage of the cargo carrier, leading to release of the API. A wide variety of stimulus-responsive systems have been developed—responsive to both a single stimulus or multiple stimuli—and represent a theranostic tool for disease treatment. In this review, stimuli commonly used in the development of theranostic nanoplatforms are enumerated. An emphasis on chemical structure and property relationships is provided, aiming to focus on insights for the design of stimulus-responsive delivery systems. Several examples of theranostic applications of these stimulus-responsive nanomedicines are discussed.

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“…Our earlier studies demonstrated the development of inflammation-responsive drug carriers with anti-inflammatory applications. − The goal of this work is to develop a CD44/FR-β targeting and catalase (CAT)-loaded photodynamic selenium nanoparticles (SeNPs) for highly selective fluorescence imaging and photodynamic treatment of proinflammatory-activated macrophages. The photodynamic SeNPs can convert endogenous H 2 O 2 that is produced in activated macrophages to oxygen to produce an oxygenated microenvironment.…”

Section: Introductionmentioning

confidence: 99%

H₂O₂-Depleting and O₂-Generating Selenium Nanoparticles for Fluorescence Imaging and Photodynamic Treatment of Proinflammatory-Activated Macrophages

Lin

Chuang

et al. 2017

ACS Appl. Mater. Interfaces

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Macrophages have a pivotal role in chronic inflammatory diseases (CIDs), so imaging and controlling activated macrophage is critical for detecting and reducing chronic inflammation. In this study, photodynamic selenium nanoparticles (SeNPs) with photosensitive and macrophage-targeting bilayers were developed. The first layer of the photosensitive macromolecule was composed of a conjugate of a photosensitizer (rose bengal, RB) and a thiolated chitosan (chitosan-glutathione), resulting in a plasmonic coupling-induced red shift and broadening of RB absorption bands with increased absorption intensity. Electron paramagnetic resonance (EPR) and diphenylanthracene (DPA) quenching studies revealed that the SeNPs that were coated with the photosensitive layer were more effective than RB alone in producing singlet oxygen (O) under photoirradiation. The second layer of the activated macrophage-targetable macromolecule was synthesized by conjugation of hyaluronic acid with folic acid using an ethylenediamine linker. Proinflammatory-activated macrophages rapidly internalized the SeNPs that were covered with the targeting ligand, exhibiting a much stronger fluorescence signal of the SeNPs than did the nonactivated macrophages. Since proinflammatory-activated macrophage was known to generate a substantial amount of HO while the inflamed site generally caused inflammation-associated tissue hypoxia, the SeNPs were further modified with O self-sufficient function for photodynamic therapy. Catalase was immobilized on the SeNPs by the formation of disulfide bonds. Intracellular reduction of disulfide bonds induced the subsequent release of catalase, which catalyzed the decomposition of HO. The HO-depleting and O-generating photodynamic SeNPs efficiently killed activated macrophages and quenched the intracellular HO and NO that are associated with inflammation. The SeNPs may have potential as a theranostic nanomaterial to image and control the activation of macrophages.

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Injectable Microbeads with a Thermo‐Responsive Shell and a pH‐Responsive Core as a Dual‐Switch‐Controlled Release System

Cited by 15 publications

References 28 publications

Responsive Nanostructure for Targeted Drug Delivery

Responsive Nanostructure for Targeted Drug Delivery

Stimulus-Responsive Nanomedicines for Disease Diagnosis and Treatment

H₂O₂-Depleting and O₂-Generating Selenium Nanoparticles for Fluorescence Imaging and Photodynamic Treatment of Proinflammatory-Activated Macrophages

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Injectable Microbeads with a Thermo‐Responsive Shell and a pH‐Responsive Core as a Dual‐Switch‐Controlled Release System

Cited by 15 publications

References 28 publications

Responsive Nanostructure for Targeted Drug Delivery

Responsive Nanostructure for Targeted Drug Delivery

Stimulus-Responsive Nanomedicines for Disease Diagnosis and Treatment

H2O2-Depleting and O2-Generating Selenium Nanoparticles for Fluorescence Imaging and Photodynamic Treatment of Proinflammatory-Activated Macrophages

Contact Info

Product

Resources

About

H₂O₂-Depleting and O₂-Generating Selenium Nanoparticles for Fluorescence Imaging and Photodynamic Treatment of Proinflammatory-Activated Macrophages