Prenatal exposure to manganese at environment relevant level and neonatal neurobehavioral development

Yu, Xiaodan; Zhang, Jun; Yan, Chen‐Hua; Shen, Xiaoming

doi:10.1016/j.envres.2014.04.012

Cited by 67 publications

(43 citation statements)

References 28 publications

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“…In a study on children (12 months of age) from Mexico City, Claus Henn et al (Claus Henn et al, 2010) reported a nonlinear association between blood manganese concentrations and concurrent mental development scores (Claus Henn et al, 2010). On the other hand two studies from Taiwan and China demonstrated that cord blood manganese concentrations above the 75 th percentile were associated with adverse cognitive, language, and overall quotients of the Comprehensive Developmental Inventory for Infants and Toddlers (Lin et al, 2013) and lower neonatal behavioral neurological assessments (Yu, Zhang, Yan, & Shen, 2014). Thus, for these analyses we categorized BMC into two levels [BMC <12 µg/L and BMC ≥12 µg/L], and herein will be called binary manganese levels.…”

Section: Methodsmentioning

confidence: 99%

Synergic effect of GSTP1 and blood manganese concentrations in Autism Spectrum Disorder

Rahbar

Samms‐Vaughan

et al. 2015

Research in Autism Spectrum Disorders

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We used data from 100 age- and sex-matched case-control pairs (age 2–8 years) from Jamaica to investigate whether there is an interaction between glutathione-S-transferase (GST) genes and blood manganese concentrations (BMC) in relation to Autism Spectrum Disorder (ASD). Our findings, indicate that among children who had the Ile/Ile genotype for GST pi 1 (GSTP1), those with BMC ≥ 12µg/L had about 4 times higher odds of ASD than those with BMC < 12µg/L, (P=0.03) under a co-dominant genetic model. After adjusting for potential confounders, among the subgroup of children with genotype Ile/Ile, those with BMC ≥ 12µg/L had about six times higher odds of ASD than those with BMC < 12µg/L, (P=0.04). The results were similar when a recessive genetic model was used. These findings suggest a possible synergic effect of BMC and GSTP1 in ASD. Since our analysis included a variety of genetic models and was not adjusted for multiple testing, replication in other populations is warranted.

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Section: Methodsmentioning

confidence: 99%

Synergic effect of GSTP1 and blood manganese concentrations in Autism Spectrum Disorder

Rahbar

Samms‐Vaughan

et al. 2015

Research in Autism Spectrum Disorders

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“…All four of the prospective studies reviewed support the notion that the prenatal and early postnatal period may be a sensitive developmental window for Mn exposure with regards to neurodevelopment [58, 61, 67, 68]. In a large prospective cohort study of neonates from China, a cord serum Mn threshold of 5 μg/L was identified, above which three-day-olds showed cognitive deficits as measured by the Neonatal Behavioral Neurological Assessment (NBNA) [67].…”

Section: Epidemiologic Evidence For Neurotoxic Effects Of Manganesementioning

confidence: 99%

“…In a large prospective cohort study of neonates from China, a cord serum Mn threshold of 5 μg/L was identified, above which three-day-olds showed cognitive deficits as measured by the Neonatal Behavioral Neurological Assessment (NBNA) [67]. However, there are well known limitations to assessing neonates, given the limited neurologic repertoire inherent in newborns.…”

Section: Epidemiologic Evidence For Neurotoxic Effects Of Manganesementioning

confidence: 99%

Perinatal and Childhood Exposure to Cadmium, Manganese, and Metal Mixtures and Effects on Cognition and Behavior: A Review of Recent Literature

Sanders

Henn

Wright

2015

Curr Envir Health Rpt

248

134

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Lead (Pb) and mercury (Hg) neurotoxicity is well established. In recent years, a growing body of evidence suggests that environmental exposure to other metals including arsenic (As), cadmium (Cd), manganese (Mn), and their mixtures also pose public health threats. In this paper we summarize the recent literature examining the relationship of prenatal and childhood environmental metal exposures with cognitive and behavioral outcomes in children. We conducted a literature search to identify epidemiologic studies that examined the relationship of Cd, Mn, and metal mixtures with children’s neurodevelopmental/cognitive and behavioral outcomes. We restricted the search to peer-reviewed studies published in English between January 2009 and March 2015. We identified a total of 31 articles of which 16, 17, and 16 studies examined the effects of Cd, Mn, or metal mixtures, respectively. Based on our review, there is suggestive evidence that prenatal/childhood Cd exposure may be associated with poorer cognition, but additional research is clearly needed. We found little evidence of behavioral effects of early life Cd exposure, and no studies found a significant relationship with attention deficit hyperactivity disorder. Studies of early life Mn exposure consistently reported negative impacts on both cognition and behavior. There is also growing evidence that co-exposure to multiple metals can result in increased neurotoxicity compared to single metal exposures, in particular during early life. Few studies have evaluated behavioral effects related to metal co-exposures.

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“…Several prospective studies have reported inverse or “U” shaped associations between Mn exposure in the prenatal or early postnatal period and performance on neurobehavioral tests in early childhood (Chung et al 2015; Claus Henn et al, 2010; Lin et al 2013; Yang et al 2014; Yu et al 2014). However, most studies assessing effects of prenatal Mn estimated fetal exposure using maternal biomarkers or umbilical cord blood (Gunier et al 2014; Smargiassi et al 2002; Zota et al 2009); yet a single blood Mn spot measurement does not comprehensively capture fetal Mn exposure across the prenatal and postnatal periods.…”

Section: Introductionmentioning

confidence: 99%

Manganese in teeth and neurobehavior: Sex-specific windows of susceptibility

Bauer

Henn

Austin

et al. 2017

Environment International

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Background Manganese (Mn) is an essential element required for growth and development, but higher body burdens have been associated with neurobehavioral decrements in children. Objectives We examined whether prenatal or postnatal Mn measured in deciduous teeth was associated with scores on a test of visuospatial learning and memory. Methods Deciduous teeth were collected from 142 participants (ages 10–14 years) residing near varied ferro-manganese industry in Italy. Mn concentrations were measured in prenatal and postnatal tooth regions by laser ablation inductively coupled plasma mass spectrometry (ICP-MS). The Virtual Radial Arm Maze (VRAM), an animal-human analogue task, was used to assess visuospatial learning and memory. We used generalized additive, linear and zero-inflated Poisson mixed regression models to estimate associations between prenatal or postnatal Mn concentrations and repeated measures of all four VRAM outcomes: time, distance, working and reference memory errors. Effect measure modification by sex was examined in stratified models. Results U-shaped associations between prenatal Mn and VRAM outcomes were observed among girls only (pGAMM =0.001 to 0.02 in stratified models). Compared to the mid-tertile of prenatal Mn, girls in the highest tertile took 7.7 seconds [95% CI: −6.1, 21.5] longer to complete the task, traveled 2.3 maze units [0.1, 4.4] farther, and committed more working and reference memory errors (β for count ratio=1.33 [1.01, 1.83]; 1.10 [0.98, 1.24], respectively). This association was not observed among boys. In contrast, for postnatal Mn, no significant associations were found, and patterns were similar for boys and girls. Conclusions The prenatal period may be a critical window for the impact of environmental Mn on visuospatial ability and executive function, especially for females.

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Prenatal exposure to manganese at environment relevant level and neonatal neurobehavioral development

Cited by 67 publications

References 28 publications

Synergic effect of GSTP1 and blood manganese concentrations in Autism Spectrum Disorder

Synergic effect of GSTP1 and blood manganese concentrations in Autism Spectrum Disorder

Perinatal and Childhood Exposure to Cadmium, Manganese, and Metal Mixtures and Effects on Cognition and Behavior: A Review of Recent Literature

Manganese in teeth and neurobehavior: Sex-specific windows of susceptibility

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