Curine inhibits mast cell-dependent responses in mice

Ribeiro-Filho, Jaime; Leite, Fagner Carvalho; Costa, Hermann Ferreira; Calheiros, Andrea Surrage; Torres, Rafael Carvalho; Azevedo, Carolina Trindade de; Martins, Marco A.; Dias, Celidarque da Silva; Bozza, Patrı́cia T.; Piuvezam, Márcia Regina

doi:10.1016/j.jep.2014.06.041

Cited by 18 publications

(15 citation statements)

References 36 publications

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“…The fact that SFBA decreased the expression of IL-31 in the mice skin pushed us to investigate the effects of SFBA on scratching behavior in mice subcutaneously administered with compound 48/80. Compound 48/80 activates mast cells in mice skin to release not only histamine but also other mediators including IL-31, which directly activate nerve fibers, thus inducing itch [29]. Compound 48/80 in this study indeed increased mast cell infiltration and degranulation as evidenced by the increase in the expression of tryptase, and increased the expression of IL-31 in the skin of the mice.…”

Section: Discussionsupporting

confidence: 52%

Soybean Fermented with Bacillus amyloliquefaciens (Cheonggukjang) Ameliorates Atopic Dermatitis-Like Skin Lesion in Mice by Suppressing Infiltration of Mast Cells and Production of IL-31 Cytokine

Cho

Shin

Kim

et al. 2019

Journal of Microbiology and Biotechnology

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Section: Discussionsupporting

confidence: 52%

Soybean Fermented with Bacillus amyloliquefaciens (Cheonggukjang) Ameliorates Atopic Dermatitis-Like Skin Lesion in Mice by Suppressing Infiltration of Mast Cells and Production of IL-31 Cytokine

Cho

Shin

Kim

et al. 2019

Journal of Microbiology and Biotechnology

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“…Wistar rat basophilic cell lineage (RBL-2H3) was kept at 37°C in a humidified 5% CO 2 : 95% air atmosphere in Dulbecco’s modified Eagle’s medium (DMEM), supplemented with 15% fetal bovine serum, penicillin 100 U/ml, and streptomycin 0.1 mg/ml as reported (39). The cells were sensitized with IgE anti-DNP antibody (1 µg/ml) at 37°C for 20 h in a humidified 5% CO 2 : 95% air atmosphere.…”

Section: Methodsmentioning

confidence: 99%

15-Deoxy-Delta-12,14-Prostaglandin J2 Inhibits Lung Inflammation and Remodeling in Distinct Murine Models of Asthma

et al. 2017

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15-deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) has been described as an anti-inflammatory lipid mediator in several in vitro and in vivo studies, but its effect on allergic pulmonary inflammation remains elusive. The aim of this study was to investigate the therapeutic potential of 15d-PGJ2 based on distinct murine models of allergic asthma triggered by either ovalbumin (OVA) or house dust mite extract (HDM). Characteristics of lung inflammation, airway hyper-reactivity (AHR), mucus exacerbation, and lung remodeling in sensitized A/J mice treated or not with 15d-PGJ2 were assessed. 15d-PGJ2 treatments were carried out systemically or topically given via subcutaneous injection or intranasal instillation, respectively. Analyses were carried out 24 h after the last allergen provocation. Irrespective of the route of administration, 15d-PGJ2 significantly inhibited the peribronchial accumulation of eosinophils and neutrophils, subepithelial fibrosis and also mucus exacerbation caused by either OVA or HDM challenge. The protective effect of 15d-PGJ2 occurred in parallel with inhibition of allergen-induced AHR and lung tissue production of pro-inflammatory cytokines, such as interleukin (IL)-5, IL-13, IL-17, and TNF-α. Finally, 15d-PGJ2 was found effective in inhibiting NF-κB phosphorylation upon HDM challenge as measured by Western blotting. In conclusion, our findings suggest that 15d-PGJ2 can reduce crucial features of asthma, including AHR, lung inflammation, and remodeling in distinct murine models of the disease. These effects are associated with a decrease in lung tissue generation of pro-inflammatory cytokines by a mechanism related to downregulation of NF-κB phosphorylation.

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“…The OVA-induced systemic anaphylaxis model is appropriate for the investigation of the anti-allergic inflammatory effects of drug candidates [9]. After challenges of OVA, mice repetitively sensitized with OVA and alum adjuvant developed anaphylaxis and were monitored for 1 h. The rectal temperature of the mice decreased over 40–50 min; administration of tyrosol alleviated this hypothermia, which was associated with the serum histamine level (Fig 1A).…”

Section: Resultsmentioning

confidence: 99%

“…Rat basophilic leukemia (RBL)-2H3 cells are suitable for in vitro studies of mast cell-mediated allergic inflammation involving the degranulation and expression of inflammatory cytokines [8]. Ovalbumin (OVA)-induced active systemic anaphylaxis (ASA) and IgE-mediated passive cutaneous anaphylaxis (PCA) are well-characterized animal models for immediate-type hypersensitivity [9,10]. …”

Section: Introductionmentioning

confidence: 99%

Tyrosol Suppresses Allergic Inflammation by Inhibiting the Activation of Phosphoinositide 3-Kinase in Mast Cells

Kim

et al. 2015

PLoS ONE

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Allergic diseases such as atopic dermatitis, rhinitis, asthma, and anaphylaxis are attractive research areas. Tyrosol (2-(4-hydroxyphenyl)ethanol) is a polyphenolic compound with diverse biological activities. In this study, we investigated whether tyrosol has anti-allergic inflammatory effects. Ovalbumin-induced active systemic anaphylaxis and immunoglobulin E-mediated passive cutaneous anaphylaxis models were used for the immediate-type allergic responses. Oral administration of tyrosol reduced the allergic symptoms of hypothermia and pigmentation in both animal models. Mast cells that secrete allergic mediators are key regulators on allergic inflammation. Tyrosol dose-dependently decreased mast cell degranulation and expression of inflammatory cytokines. Intracellular calcium levels and activation of inhibitor of κB kinase (IKK) regulate cytokine expression and degranulation. Tyrosol blocked calcium influx and phosphorylation of the IKK complex. To define the molecular target for tyrosol, various signaling proteins involved in mast cell activation such as Lyn, Syk, phosphoinositide 3-kinase (PI3K), and Akt were examined. Our results showed that PI3K could be a molecular target for tyrosol in mast cells. Taken together, these findings indicated that tyrosol has anti-allergic inflammatory effects by inhibiting the degranulation of mast cells and expression of inflammatory cytokines; these effects are mediated via PI3K. Therefore, we expect tyrosol become a potential therapeutic candidate for allergic inflammatory disorders.

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Curine inhibits mast cell-dependent responses in mice

Cited by 18 publications

References 36 publications

Soybean Fermented with Bacillus amyloliquefaciens (Cheonggukjang) Ameliorates Atopic Dermatitis-Like Skin Lesion in Mice by Suppressing Infiltration of Mast Cells and Production of IL-31 Cytokine

Soybean Fermented with Bacillus amyloliquefaciens (Cheonggukjang) Ameliorates Atopic Dermatitis-Like Skin Lesion in Mice by Suppressing Infiltration of Mast Cells and Production of IL-31 Cytokine

15-Deoxy-Delta-12,14-Prostaglandin J2 Inhibits Lung Inflammation and Remodeling in Distinct Murine Models of Asthma

Tyrosol Suppresses Allergic Inflammation by Inhibiting the Activation of Phosphoinositide 3-Kinase in Mast Cells

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