Coagulation and fibrinolysis during lung surgery:an experimental study

Abstract

A wide range of fibrinolytic and anticoagulant substances remained unchanged during experimental lung manipulation. Minor changes were transient and not considered clinically relevant. Future studies should be initiated in humans because we have no deeper understanding why thromboembolic complications are relatively uncommon after general thoracic surgery compared with other surgical specialties.

Video-assisted Thoracoscopic surgery (VATS) lobectomy for lung cancer does not induce a procoagulant state

“…The previously published studies within this area have some major limitations. The study by Trabjerg et al [ 7 ] employed a porcine non-cancerous model, which does not necessarily reflect changes occurring in human coagulation [ 14 ]. The studies by Papageorgiou et al [ 5 ] and Swiniarska et al [ 6 ] had the drawback of using mainly standard blood analysis and determination of tissue factor concentration instead of global analysis as e.g.…”

“…Papageorgiou et al [ 5 ] found patients with lung adenocarcinoma undergoing lobectomy to be hypercoagulable pre- and postoperatively, whereas Swiniarska et al [ 6 ] reported that surgery resulted in an activation of the coagulation system, however significantly more profound in pneumonectomies compared to lobectomies. In a porcine model Trabjerg et al [ 7 ] showed that there was no significant activation of the coagulation system during lung surgery. Thus, results of the published studies are conflicting and inconclusive.…”