Nasopharyngeal amyloidosis: an unusual cause of unilateral hearing loss

Mirza, AH; El-Shunnar, Suliman; Sama, Anshul

doi:10.1093/jscr/rjs048

Cited by 6 publications

(2 citation statements)

References 8 publications

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“…However, in dispersed amyloid deposits in the tubal protuberance, surgical excision can lead to damages resulting in a worsening Eustachian tube dysfunction [15,16]. Several of the reported cases showed no further impairment after surgical removal [10,17], but a massive regrowth of the lesion to a massive size has also been reported [13]. Due to the lack of medical treatment for localized amyloidosis, surgical excision and clinical follow up exams may become necessary.…”

Section: Case Report Discussionmentioning

confidence: 99%

Eustachian Tube Dysfunction in Patients with Localized Amyloidosis of the Nasopharynx and Eustachian Tube

Lauer¹,

Quast²,

Ligum³

et al. 2018

AOHNS

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Section: Case Report Discussionmentioning

confidence: 99%

Eustachian Tube Dysfunction in Patients with Localized Amyloidosis of the Nasopharynx and Eustachian Tube

Lauer¹,

Quast²,

Ligum³

et al. 2018

AOHNS

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“…There is no definite treatment established for localised amyloidosis 4. However, surgical excision is still the preferable treatment 2–5 7.…”

Section: Discussionmentioning

confidence: 99%

Localised nasopharyngeal amyloidosis: the importance of postoperative follow-up

Chowsilpa¹,

Chaiyasate

Wannasai

et al. 2018

BMJ Case Reports

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Localised nasopharyngeal amyloidosis is rare. Findings on physical examination and invasive pattern on CT scan can be misleading as it can resemble nasopharyngeal carcinoma. A 64-year-old man presented with left aural fullness for 6 months. The physical examination showed straw-coloured fluid in the left middle ear and irregular reddish mass at the left side of the nasopharynx. The CT scan showed a lobulated heterogeneous mass at the left side of the nasopharynx involving the left Eustachian tube opening. Pathology report was amyloidosis, thus, surgery was done. After a year, there were new foci of amyloidosis at the right side of the nasopharynx, and a repeat surgery was performed. Two years later, the systemic amyloidosis with underlying IgG4-related disease was suspected due to multiple organ involvement. Surgery is the treatment for localised amyloidosis with compressive symptoms. Close follow-up is important after surgical excision due to its recurrence and progression to systemic amyloidosis.

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Nasopharyngeal amyloidoma: report of three cases and review of the literature

Zuo,

Du,

Chen

2024

J Cancer Res Clin Oncol

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Background Nasopharyngeal amyloidoma is a rare, locally aggressive tumor that has been reported in the English literature in only 38 cases to date, most of which were in the form of case reports. The present study was aimed to summarize the characteristics of this rare tumor, with the goal of providing new insights for diagnosis and treatment. Materials and methods We report three cases of nasopharyngeal amyloidoma diagnosed in our hospital following comprehensive medical examination and review the current literature on all cases of nasopharyngeal amyloidoma from PubMed. The journey of nasopharyngeal amyloidoma, including presentation, diagnostics, surgeries, and follow-up was outlined. Results None of the three patients had systemic amyloidosis. CT and nasal endoscopy showed irregular masses obstructing the nasopharyngeal cavity. Congo red staining confirmed the deposition of amyloid, and immunohistochemical analysis showed that the amyloid deposition was the AL light chain type. Through literature review, we found that nasopharyngeal amyloidoma most commonly occurred in individuals over the age of 40, patients usually had a good prognosis after complete tumor resection; however, there were still cases of recurrence, and unresected patients were at risk of progression to systemic amyloidosis. The efficacy of radiotherapy and chemotherapy was currently uncertain. Conclusion Early clinical and pathological diagnosis is crucial, and surgical intervention is the primary treatment option for this disease. Although patients usually have a favorable prognosis, long-term monitoring is necessary to detect potential relapses and initiate timely intervention.

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Nasopharyngeal amyloidosis: an unusual cause of unilateral hearing loss

Cited by 6 publications

References 8 publications

Eustachian Tube Dysfunction in Patients with Localized Amyloidosis of the Nasopharynx and Eustachian Tube

Eustachian Tube Dysfunction in Patients with Localized Amyloidosis of the Nasopharynx and Eustachian Tube

Localised nasopharyngeal amyloidosis: the importance of postoperative follow-up

Nasopharyngeal amyloidoma: report of three cases and review of the literature

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