An increase in the cerebral infarction area during fatigue is mediated by il-6 through an induction of fibrinogen synthesis

Lei, Hong; Cheng, Lijuan; Guo, Qi; Deng, An-mei; Li, Yong-Shen

doi:10.6061/clinics/2014(06)10

Cited by 5 publications

(5 citation statements)

References 27 publications

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“…Fibrinogen is regulated by interleukin-6 (IL-6) in adipose tissue and adipose tissue IL-6 expression was shown to be positively correlated with obesity. IL-6 was found to be the major regulator of fibrinogen, and stimulated fibrinogen synthesis [ 30 ]. In high fat diet-induced atherosclerosis in rabbits, high levels of IL-6 and fibrinogen were detected in the plasma [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative proteome analysis of abdominal adipose tissues between fat and lean broilers

Liu

Wang

et al. 2016

Proteome Sci

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BackgroundThe molecular mechanism underlying broiler fat deposition is still poorly understood.MethodCurrently, we used two-dimensional gel electrophoresis (2DE) to identify differentially expressed proteins in abdominal adipose tissues of birds at 4 week of age derived from Northeast Agricultural University broiler lines divergently selected for abdominal fat content (NEAUHLF).ResultsThirteen differentially expressed protein spots were screened out and identified by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF-MS). The protein spots were matched to thirteen proteins by searching against the NCBInr database. These identified proteins were apolipoprotein A-I (Apo A-I), cytokeratin otokeratin, ATP synthase subunit alpha, peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4), aspartate aminotransferase, carbonic anhydrase II (CA-II), prostaglandin-H2 D-isomerase precursor, fibrinogen alpha chain, lamin-A (LMNA), superoxide dismutase [Mn] (MnSOD), heat shock protein beta-1 (HSPβ1) and two predicted proteins. These differentially expressed proteins are involved mainly in lipid metabolism, amino acid metabolism, signal transduction, energy conversion, antioxidant, and cytoskeleton. Differential expression of Apo A-I, PPIase FKBP4, and cytokeratin otokeratin proteins were further confirmed by Western blot analysis. Quantitative real-time RT-PCR analyses showed that, of these 13 differentially expressed proteins, only PPIase FKBP4 and cytokeratin otokeratin were differentially expressed at mRNA level between the two lines.ConclusionsOur results have provided further information for understanding the basic genetics control of growth and development of broiler adipose tissue.

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Section: Discussionmentioning

confidence: 99%

Comparative proteome analysis of abdominal adipose tissues between fat and lean broilers

Liu

Wang

et al. 2016

Proteome Sci

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“…This conclusion seemed to be in accordance with previous studies. For example, Zang et al[28] found the level of fibrinogen increased in patients with progressive cerebral infarction more than those in the nonprogressive group on days 3, 7, and 14; Lei et al [29] reported that the formation of cerebral artery occlusion was attributed to interleukin-6 mediated fibrinogen synthesis. However, its accuracy may be inferior to that of Hcy according to the AUC (0.688 vs. 0.881).…”

Section: Discussionmentioning

confidence: 99%

Assessment of Homocysteine as a Diagnostic and Early Prognostic Biomarker for Patients with Acute Lacunar Infarction

Fan

Yang

et al. 2017

Eur Neurol

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Background: Although increasing evidence has demonstrated that elevated homocysteine (Hcy) levels may be an important contributor for the development of cerebral infarction, rare studies focused on its diagnostic and early prognostic roles in acute lacunar infarction. Methods: A total of 197 patients with acute lacunar infarction and 192 to form the control group were prospectively recruited between January 2013 and February 2017. Early neurological deterioration was defined as an increase of ≥2 points in National Institutes of Health Stroke Scale or the decrease in Barthel index (BI) score at discharge. Results: Univariate and multivariate logistic regression analyses revealed that higher levels of fibrinogen and Hcy were independently clinical predictors associated with lacunar infarction. Receiver operating characteristic curves analysis demonstrated that the diagnosis value of Hcy was superior to fibrinogen, with the area under the curve of 0.881 and 0.688 respectively. Using the optimal cutoff value of 15.5 μmol/L of Hcy, a sensitivity of 65% and a specificity of 100% were achieved for predicting lacunar infarction. Hcy was only significantly related with BI reduction in the males (30.5 [15.5–65.5] vs. 18 [15–24], p = 0.034) in the univariate analysis but not in the females and the multivariate analysis. Conclusions: Serum Hcy may be an independent diagnostic and not an early prognostic biomarker for patients with acute lacunar infarction.

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“…Among the core inflammatory factors targets, both IL1B and IL6 are well recognized as key proinflammatory cytokines with a significant proinflammatory effect (103). The IL-6 levels in the serum of fatigued rats were observed to be increased (104). A similar phenomenon was reported in chronic fatigue patients (105).…”

Section: Discussionmentioning

confidence: 60%

Feasibility study on the use of “Qi-tonifying medicine compound” as an anti-fatigue functional food ingredient based on network pharmacology and molecular docking

Cao

et al. 2023

Front. Nutr.

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IntroductionFatigue has attracted broad attention in recent years due to its high morbidity rates. The use of functional foods to relieve fatigue-associated symptoms is becoming increasingly popular and has achieved relatively good results. In this study, network pharmacology and molecular docking strategies were used to establish the material basis and mechanisms of Chinese herbal compounds in fatigue treatment. According to traditional medicine theories and relevant guidance documents published by the Chinese Ministry of Health, four herbal medicines, including Eucommia ulmoides Oliver bark, Eucommia ulmoides Oliver male flower, Panax notoginseng, and Syzygium aromaticum (EEPS), were selected to constitute the anti-fatigue herbal compound that may be suitable as functional food ingredients.MethodsThe major active ingredients in EEPS were identified via comprehensive literature search and Traditional Chinese Medicine Systems Pharmacology database search. Corresponding targets for these ingredients were predicted using SwissTargetPrediction. The network was constructed using Cytoscape 3.9.1 to obtain key ingredients. Prediction of absorption, distribution, metabolism, excretion and toxicity properties was performed using the ADMETIab 2.0 database. The anti-fatigue targets were retrieved from GeneCards v5.13, OMIM, TTD and DisGeNET 7.0 databases. Then, the potential targets of EEPS in fatigue treatment were screened through a Venn diagram. A protein–protein interaction (PPI) network of these overlapping targets was constructed, and the hub targets in the network selected through topological screening. Gene Ontology and KEGG pathway enrichment analyses were performed using the DAVID database and the bioinformatics online platform. Finally, AutoDock tools were used to verify the binding capacity between the key active ingredients and the core targets.Results and DiscussionThis study identified the active ingredients and potential molecular mechanisms of EEPS in fatigue treatment, which will provide a foundation for future research on applications of herbal medicines in the functional food industry.

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An increase in the cerebral infarction area during fatigue is mediated by il-6 through an induction of fibrinogen synthesis

Cited by 5 publications

References 27 publications

Comparative proteome analysis of abdominal adipose tissues between fat and lean broilers

Comparative proteome analysis of abdominal adipose tissues between fat and lean broilers

Assessment of Homocysteine as a Diagnostic and Early Prognostic Biomarker for Patients with Acute Lacunar Infarction

Feasibility study on the use of “Qi-tonifying medicine compound” as an anti-fatigue functional food ingredient based on network pharmacology and molecular docking

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