miR-92a regulates TGF-β1-induced WISP1 expression in pulmonary fibrosis

Berschneider, Barbara; Ellwanger, Daniel C.; Baarsma, Hoeke A.; Thiel, C; Shimbori, Chiko; White, Eric S.; Kolb, Martin; Neth, Peter; Königshoff, Mélanie

doi:10.1016/j.biocel.2014.06.011

Cited by 82 publications

(79 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…miR-92a was identified to be downregulated in lungs from patient with IPF. miR-92a directly targeted WNT1-inducible signaling pathway protein 1 (WISP1), a profibrotic mediator in IPF, and thereby inhibiting pulmonary fibrosis [71]. miR-27b, another miRNA downregulated in TGF-β1 treated lung fibroblasts, was found to diminish the expression of several profibrotic genes likely by targeting Gremlin1.…”

Section: Mirnas and Lung Fibrosismentioning

confidence: 99%

The code of non-coding RNAs in lung fibrosis

Xie

Thannickal

Liu

2015

Cell. Mol. Life Sci.

View full text Add to dashboard Cite

The pathogenesis of pulmonary fibrosis is a complicated and complex process that involves phenotypic abnormalities of a variety of cell types and dysregulations of multiple signaling pathways. There are numerous genetic, epigenetic and posttranscriptional mechanisms that have been identified to participate in the pathogenesis of this disease. However, efficacious therapeutics developed from these studies have been disappointingly limited. In the past several years, a group of new molecules, i.e. non-coding RNAs (ncRNAs), has been increasingly appreciated to have critical roles in the pathological progression of lung fibrosis. In this review, we summarize the recent findings on the roles of ncRNAs in the pathogenesis of this disorder. We analyze the translational potential of this group of molecules in treating lung fibrosis. We also discuss challenges and future opportunities of studying and utilizing ncRNAs in lung fibrosis.

show abstract

Section: Mirnas and Lung Fibrosismentioning

confidence: 99%

The code of non-coding RNAs in lung fibrosis

Xie

Thannickal

Liu

2015

Cell. Mol. Life Sci.

View full text Add to dashboard Cite

show abstract

“…Increasing evidence suggests that miRNAs play important roles in the development of many diseases. Recently, a number of studies have proved that miRNAs are also involved in the initial stage and progression of pulmonary fibrosis and may be new therapeutic targets for fibrogenic lung diseases, including IPF (Berschneider et al, 2014;Liang et al, 2014a;Xiao et al, 2012;Yang et al, 2012Yang et al, , 2013. However, the screening and study of miRNAs in pulmonary fibrosis is still in the early stages.…”

Section: Introductionmentioning

confidence: 96%

The anti-fibrotic effects of microRNA-153 by targeting TGFBR-2 in pulmonary fibrosis

Liang

Zhou

et al. 2015

Experimental and Molecular Pathology

View full text Add to dashboard Cite

“…WISP-1 was highly expressed in many fibrosis diseases, such as liver fibrosis and idiopathic pulmonary fibrosis (IPF). In liver fibrosis, WISP-1 promoted the proliferation of hepatic stellate cells (HSCs) (40), whereas the expression of WISP-1 was regulated by miR92a at regions of human WISP-1 3’-untranslated region (3’UTR) in IPF (41). WISP-1 was also involved in the regulation of osteogenesis through the association with integrin, which could mediate osteogenesis effects of bone morphogenetic protein-2 (BMP-2) (42).…”

Section: Wisp-1 Proteins In Other Pathologic Processesmentioning

confidence: 99%

Dual effect of WISP-1 in diverse pathological processes

Feng

Jia²

2016

Chinese Journal of Cancer Research

View full text Add to dashboard Cite

Wnt-1 inducible signaling pathway-1 (WISP-1), also known as CCN-4, belongs to the connective tissue growth factor (CTGF) family. WISP-1 is primarily expressed in embryonic stem cells and is involved in adult organ development. WISP-1 participates in many cellular processes, including proliferation, differentiation, apoptosis and adhesion. In addition, WISP-1 plays an important role in diverse pathophysiological processes, such as embryonic development, inflammation, injury repairs and cancers. Recent studies showed that WISP-1 was highly correlated with tumor progression and malignant transformation, whereas it played an oncogenic role in colorectal cancer, cholangiocarcinoma, hepatocellular carcinoma and breast cancer. However, interestingly, WISP-1 exerts a tumor-suppressing role in lung and prostate cancers. WISP-1 promotes cell proliferation, adhesion, motility, invasion, metastasis and epithelial-to-mesenchymal transition via particular signaling pathways. In this review, we discussed the structure, expression profile, functions, clinical significance and potential mechanisms of WISP-1 in cancer and non-neoplastic diseases.

show abstract

miR-92a regulates TGF-β1-induced WISP1 expression in pulmonary fibrosis

Cited by 82 publications

References 57 publications

The code of non-coding RNAs in lung fibrosis

The code of non-coding RNAs in lung fibrosis

The anti-fibrotic effects of microRNA-153 by targeting TGFBR-2 in pulmonary fibrosis

Dual effect of WISP-1 in diverse pathological processes

Contact Info

Product

Resources

About