Central Nervous System Tumor Distribution at a Tertiary Referral Center in Uganda

Hatef, Jeffrey; Adamson, Cory; Obiga, Oscar; Taremwa, Blessing; Ssenyojo, Hussein; Muhumuza, Michael; Haglund, Michael M.; Schroeder, Kristin

doi:10.1016/j.wneu.2014.06.040

Cited by 20 publications

(18 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The most frequent tumor location in our patients was the infratentorial compartment, just like in some series from and outside Europe [ 31 , 33 , 36 – 38 ]. However, the series from Greece, Portugal, Australia, New Zealand, and Japan demonstrated the supratentorial compartment as a predominant site [ 19 , 22 , 26 , 32 , 39 ].…”

Section: Discussionsupporting

confidence: 66%

See 1 more Smart Citation

Clinical profile, treatment and outcome of pediatric brain tumors in Serbia in a 10-year period: A national referral institution experience

et al. 2021

View full text Add to dashboard Cite

Objective This study aimed to evaluate the characteristics of children with primary brain tumors, the effectiveness of treatment modalities, and to detect factors related to the outcome. Methods A detailed analysis was performed on a series of 173 pediatric patients treated in a Serbian referral oncology institution between 2007 and 2016, based on their clinical, histological, treatment, and follow-up data. Results Mean survival time of all children was 94.5months. 2-, 5- and 10-year overall survival probabilities were 68.8%, 59.4%, and 52.8%, respectively. Patients with supratentorial tumors had longer survival than patients with infratentorial tumors and patients with tumors in both compartments (p = 0.011). Children with the unknown histopathology (brainstem glioma) and high-grade glioma had a shorter life than embryonal tumors, ependymoma, and low-grade glioma (p<0.001). Survival of the children who underwent gross total resection was longer than the children in whom lesser degrees of resection were achieved (p = 0.015). The extent of the disease is a very important parameter found to be associated with survival. Patients with no evidence of disease after surgery had a mean survival of 123 months, compared with 82 months in patients with local residual disease and 55 months in patients with disseminated disease (p<0.001). By the univariate analysis, factors predicting poor outcome in our series were the presentation of disease with hormonal abnormalities, tumor location, and the extent of the disease, while the factors predicting a better outcome were age at the time of diagnosis, presentation of the disease with neurological deficit, and type of resection. By the multivariate analysis, the extent of the disease remained as the only strong adverse risk factor for survival (HR 2.06; 95% CI = 1.38–3.07; p<0.001). Conclusions With an organized and dedicated multidisciplinary team, the adequate outcomes can be achieved in a middle-income country setting. The presence of local residual disease after surgery and disseminated disease has a strong negative effect on survival.

show abstract

Section: Discussionsupporting

confidence: 66%

“…Authors from New Zealand reported a lower rate of GTR in 35.5% of their patients, similar to our results, determined by an immediate (within 72 hours) postoperative imaging in the majority [ 26 ]. In Uganda, 1.2% of tumors were biopsied and only 25.5% more resected [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical profile, treatment and outcome of pediatric brain tumors in Serbia in a 10-year period: A national referral institution experience

et al. 2021

View full text Add to dashboard Cite

show abstract

“…[1, 3, 6-14, 16, 18, 19, 22-24, 28, 30] [ Table 4] In the Ugandan study, 40% of the CNS tumors identified were unclassified. [11] In 72% of the LMIC and 100% of the HIC, astrocytomas were the most common. The trends in tumor distributions in HIC were largely homogenous, with medulloblastoma observed as the second most common type in all HIC with the exception of Japan.…”

Section: Literature Reviewmentioning

confidence: 99%

Pediatric Central Nervous System Tumors in Nepal: Retrospective Analysis and Literature Review of Low- and Middle-Income Countries

et al. 2015

View full text Add to dashboard Cite

“…En cambio, los glioblastomas presentan una mayor incidencia entre los 60 y 74 años (14), lo que es concordante con nuestros hallazgos. Existen teorías que sugieren la influencia hormonal en el desarrollo de meningiomas (22); según Qi et al (23) el riesgo de tener meningioma aumenta un 19 % en mujeres que usan terapia de reemplazo hormonal.…”

Section: Discussionunclassified

Características clínicas y patológicas de pacientes con tumores del sistema nervioso central en un centro en Suramérica desde 2010 hasta 2015

Jaramillo-Jiménez¹,

Vargas-García

Rodríguez-Márquez

et al. 2020

CES Med

View full text Add to dashboard Cite

Objetivo: Caracterizar los pacientes diagnosticados con tumores del sistema nervioso central en el Instituto Neurológico de Colombia durante el periodo 2010-2015. Métodos: Estudio descriptivo retrospectivo. Para los tumores primarios se usó la clasificación de la Organización Mundial de la Salud y para los metastásicos se usó la Clasificación Internacional de Enfermedades en Oncología. Resultados: Se identificaron 288 pacientes, 194 de ellos con tumores primarios y 94 tumores metastásicos. No se lograron clasificar los tumores primarios en el 23,7 % de los casos y para los metastásicos no se obtuvo la clasificación morfológica (histológica) en el 35,1 % de los casos. Los hombres presentaron con mayor frecuencia tumores de comportamiento maligno tipo glioblastoma NEO (no especificado de otra manera) (14,9 %) y en las mujeres predominaron los tumores de comportamiento benigno tipo meningioma (23,2 %). En mayores de 65 años, tanto el glioblastoma NEO como el meningioma fueron más frecuentes en mujeres con 17,4 % y 28,3 %, respectivamente. Entre los pacientes con tumores metastásicos, de acuerdo con la clasificación topográfica, los tumores primarios más frecuentes se localizaron en pulmón (39,4 %) y mama (17 %). No se identificó el sitio primario de metástasis en el 11,7 % de los casos. La histología más comúnmente identificada fue el adenocarcinoma (14,9 %), seguido del carcinoma (8,5 %). Conclusiones: Para una vigilancia efectiva de la enfermedad es necesario realizar un monitoreo epidemiológico y clínico de tumores primarios y metastásicos, mediante el uso de registros institucionales de cáncer incluyendo datos topográficos, histológicos y moleculares, según disponibilidad.

show abstract

Central Nervous System Tumor Distribution at a Tertiary Referral Center in Uganda

Cited by 20 publications

References 23 publications

Clinical profile, treatment and outcome of pediatric brain tumors in Serbia in a 10-year period: A national referral institution experience

Clinical profile, treatment and outcome of pediatric brain tumors in Serbia in a 10-year period: A national referral institution experience

Pediatric Central Nervous System Tumors in Nepal: Retrospective Analysis and Literature Review of Low- and Middle-Income Countries

Características clínicas y patológicas de pacientes con tumores del sistema nervioso central en un centro en Suramérica desde 2010 hasta 2015

Contact Info

Product

Resources

About