Correlation between the severity of coronary artery lesions and levels of estrogen, hs-CRP and MMP-9

Abstract

The aim of this study was to investigate the correlation between the severity of coronary artery lesions in patients with acute coronary syndromes (ACS) and levels of estrogen, high-sensitivity C-reactive protein (hs-CRP) and matrix metalloproteinase-9 (MMP-9). A total of 65 patients with ACS, 33 patients with stable angina pectoris (SAP) and 36 healthy controls were randomly enrolled. Patients with ACS were subdivided into two groups: Acute myocardial infarction (AMI; n=30) and unstable angina pectoris (UAP; n=35). Serum levels of estrogen, hs-CRP and MMP-9 were detected in the four groups of subjects. Serum estrogen levels in patients with AMI, UAP and SAP were significantly lower than those in the control group (P<0.05). Estrogen levels were also significantly different among the AMI, UAP and SAP groups (P<0.05), with a progressive increase across the three respective groups. Compared with healthy subjects, patients with AMI had the highest levels of hs-CRP and MMP-9, followed in descending order by those with UAP and SAP (P<0.05). Levels of hs-CRP and MMP-9 were also significantly different among the AMI, UAP and SAP groups (P<0.05). Serum estrogen levels were negatively correlated with hs-CRP and MMP-9 levels (r=−0.6634 and −0.6878, respectively; both P<0.05). hs-CRP and MMP-9 levels correlated positively (r=0.7208, P<0.05). The number of stenosed coronary vessels was negatively correlated with estrogen levels (r=−0.6467, P<0.05), and positively correlated with hs-CRP and MMP-9 levels (r=0.6519 and 0.6835, respectively; both P<0.05). In conclusion, serum estrogen, hs-CRP and MMP-9 levels were significantly correlated with the severity of coronary artery lesions. There was also a significant correlation between serum estrogen, hs-CRP and MMP-9 levels. These data indicate that serum estrogen, hs-CRP and MMP-9 have the potential to be used as biomarkers for evaluating the severity of coronary artery lesions and the stability of coronary artery plaques.

The Effects of Serum hs-CRP on the Incidence of Lung Cancer in Male Patients with Pulmonary Tuberculosis

“…The results of this study showed that there were differences in the age, drinking, smoking, diabetes history, BMI, TG, history of hypertension and hyperglycemia among the three groups, and the differences were statistically significant ( P <0.05). This is similar to the results of previous studies (12). The age, smoking, drinking, BMI and other factors were corrected in this study with patients in group A (hs-CRP<1 mg/L) as control group, and the multivariate Cox proportional risk regression model analysis results showed that the incidence rates of lung cancer in patients in group B and C were 1.37 and 1.69 times as high as that in group A respectively.…”

Clinical Relevance of Matrix Metalloproteinase 9 in Patients With Acute Coronary Syndrome

“…Similar results were found in other studies. 12,[18][19][20][21] This may indicate that the levels of MMP-9 progressively increase with severity of the clinical presentation.…”

Dose-Dependent Inhibitory Effect of Rosuvastatin in Japanese Patients with Acute Myocardial Infarction on Serum Concentration of Matrix Metalloproteinases–INVITATION Trial–

“…For the primary hypothesis, sample size estimation was based on detecting a difference of 7% in the rate of MMP-9 change from baseline between rosuvastatin 10 mg and 2.5 mg. The average rate of change in the MMP-9 level after administering rosuvastatin 10 mg or 2.5 mg was assumed to be 22% and 15%, respectively [15][16][17][18] . There was no report on the standard deviation (SD) for the MMP-9 percent change.…”