Pre-clinical functional Magnetic Resonance Imaging part I: The kidney

Zöllner, Frank G.; Kalayciyan, Raffi; Chacon‐Caldera, Jorge; Zimmer, F.; Schad, Lothar R.

doi:10.1016/j.zemedi.2014.05.002

Cited by 13 publications

(11 citation statements)

References 162 publications

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“…Functional MRI provides several approaches, such as diffusion‐weighted imaging, blood oxygen level dependent imaging, arterial spin labelling, longitudinal and transverse relaxation time measurements, dynamic contrast enhanced imaging, hyperpolarized MRS, and sodium MRI, to assess renal function and pathophysiology beside anatomical information. All these MRI‐based methods may be useful to determine renal pathology by quantification of renal water diffusion, oxygenation, perfusion, tissue water content, and viability …”

Section: Introductionmentioning

confidence: 99%

“…Functional MRI provides several approaches, 6 such as diffusionweighted imaging, 7 blood oxygen level dependent imaging, 8 arterial spin labelling, [9][10][11] longitudinal and transverse relaxation time measurements, 12,13 dynamic contrast enhanced imaging, 14 hyperpolarized MRS, 15 and sodium MRI, 16 to assess renal function and pathophysiology beside anatomical information. All these MRI-Abbreviations used: AKI, acute kidney injury; ATN, acute tubular necrosis; BUN, blood urea nitrogen; CEST, chemical exchange saturation transfer; KIRI, kidney ischemia reperfusion injury; ROI, region of interest; sCr, serum creatinine based methods may be useful to determine renal pathology by quantification of renal water diffusion, oxygenation, perfusion, tissue water content, and viability.…”

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confidence: 99%

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Noninvasive evaluation of renal pH homeostasis after ischemia reperfusion injury by CEST‐MRI

et al. 2017

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Acute kidney injury (AKI) in mice caused by sustained ischemia followed by reperfusion is associated with acute tubular necrosis and renal dysfunctional blood flow. Although the principal role of the kidney is the maintenance of acid-base balance, current imaging approaches are unable to assess this important parameter, and clinical biomarkers are not robust enough in evaluating the severity of kidney damage. Therefore, novel noninvasive imaging approaches are needed to assess the acid-base homeostasis in vivo. This study investigates the usefulness of MRI-chemical exchange saturation transfer (CEST) pH imaging (through iopamidol injection) in characterizing moderate and severe AKI in mice following unilateral ischemia reperfusion injury. Moderate (20 min) and severe (40 min) ischemia were induced in Balb/C mice, which were imaged at several time points thereafter (Days 0, 1, 2, 7). A significant increase of renal pH values was observed as early as one day after the ischemia reperfusion damage for both moderate and severe ischemia. MRI-CEST pH imaging distinguished the evolution of moderate from severe AKI. A recovery of normal renal pH values was observed for moderate AKI, whereas a persisting renal pH increase was observed for severe AKI on Day 7. Renal filtration fraction was significantly lower for clamped kidneys (0.54-0.57) in comparison to contralateral kidneys (0.84-0.86) following impairment of glomerular filtration. The severe AKI group showed a reduced filtration fraction even after 7 days (0.38 for the clamped kidneys). Notably, renal pH values were significantly correlated with the histopathological score. In conclusion, MRI-CEST pH mapping is a valid tool for the noninvasive evaluation of both acid-base balance and renal filtration in patients with ischemia reperfusion injury.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Noninvasive evaluation of renal pH homeostasis after ischemia reperfusion injury by CEST‐MRI

et al. 2017

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“…The fast quadrupolar relaxation recovers some of the disadvantages of imaging 23 Na, as very short repetition times (TR) can be used, albeit the ultrafast T * 2 relaxation imposing constraints on the imaging technique used. Commonly, the total (meaning from both the intra-and extracellular compartments) sodium signal is acquired through the use of surface or RF volume coils, at high magnetic field strengths (3-9.4 T) using gradient echo-based imaging technique [3][4][5][6]. It is possible to suppress some of the extracellular signal, to give an "intracellular weighted" image, with advanced techniques such as inversion signal nulling or triple quantum filtering (TQF) [7,8].…”

Section: Introductionmentioning

confidence: 99%

Sodium (23Na) MRI of the Kidney: Basic Concept

Grist

Hansen

Zöllner

et al. 2021

Methods in Molecular Biology

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The handling of sodium by the renal system is a key indicator of renal function. Alterations in the corticomedullary distribution of sodium are considered important indicators of pathology in renal diseases. The derangement of sodium handling can be noninvasively imaged using sodium magnetic resonance imaging (23Na MRI), with data analysis allowing for the assessment of the corticomedullary sodium gradient. Here we introduce sodium imaging, describe the existing methods, and give an overview of preclinical sodium imaging applications to illustrate the utility and applicability of this technique for measuring renal sodium handling.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This introduction chapter is complemented by two separate chapters describing the experimental procedure and data analysis.

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“…In prostate cancer DCE-MR perfusion imaging has developed as one part of a multi-parametric approach to stage cancer [ 12 , 13 ]. It is also applied in preclinical functional imaging [ 14 , 15 ]. However, even after 20 years of intense research in this field, perfusion imaging by DCE-MRI still remains a research tool without a broad clinical usage.…”

Section: Introductionmentioning

confidence: 99%

An open source software for analysis of dynamic contrast enhanced magnetic resonance images: UMMPerfusion revisited

et al. 2016

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BackgroundPerfusion imaging has become an important image based tool to derive the physiological information in various applications, like tumor diagnostics and therapy, stroke, (cardio-) vascular diseases, or functional assessment of organs. However, even after 20 years of intense research in this field, perfusion imaging still remains a research tool without a broad clinical usage. One problem is the lack of standardization in technical aspects which have to be considered for successful quantitative evaluation; the second problem is a lack of tools that allow a direct integration into the diagnostic workflow in radiology.ResultsFive compartment models, namely, a one compartment model (1CP), a two compartment exchange (2CXM), a two compartment uptake model (2CUM), a two compartment filtration model (2FM) and eventually the extended Toft’s model (ETM) were implemented as plugin for the DICOM workstation OsiriX. Moreover, the plugin has a clean graphical user interface and provides means for quality management during the perfusion data analysis. Based on reference test data, the implementation was validated against a reference implementation. No differences were found in the calculated parameters.ConclusionWe developed open source software to analyse DCE-MRI perfusion data. The software is designed as plugin for the DICOM Workstation OsiriX. It features a clean GUI and provides a simple workflow for data analysis while it could also be seen as a toolbox providing an implementation of several recent compartment models to be applied in research tasks. Integration into the infrastructure of a radiology department is given via OsiriX. Results can be saved automatically and reports generated automatically during data analysis ensure certain quality control.

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Pre-clinical functional Magnetic Resonance Imaging part I: The kidney

Cited by 13 publications

References 162 publications

Noninvasive evaluation of renal pH homeostasis after ischemia reperfusion injury by CEST‐MRI

Noninvasive evaluation of renal pH homeostasis after ischemia reperfusion injury by CEST‐MRI

Sodium (23Na) MRI of the Kidney: Basic Concept

An open source software for analysis of dynamic contrast enhanced magnetic resonance images: UMMPerfusion revisited

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