The Predictive Ability of the CHADS2 and CHA2DS2-VASc Scores for Bleeding Risk in Atrial Fibrillation: The MAQI2 Experience

Barnes, Geoffrey D.; Gu, Xiaokui; Haymart, Brian; Kline–Rogers, Eva; Almany, Steve; Kozlowski, J; Besley, Dennis; Krol, Gregory D.; Froehlich, James B.; Kaatz, Scott

doi:10.1016/j.thromres.2014.05.034

Cited by 33 publications

(33 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…After we read the titles and abstracts, 70 full‐text studies were included in the review. Eleven of these studies fulfilled the inclusion criteria (11 of good quality) . Table shows the basic characteristics of the 11 included studies.…”

Section: Resultsmentioning

confidence: 99%

The HAS‐BLED Score for Predicting Major Bleeding Risk in Anticoagulated Patients With Atrial Fibrillation: A Systematic Review and Meta‐analysis

Zhu

Guo

et al. 2015

Clinical Cardiology

168

View full text Add to dashboard Cite

Our objective was to compare the diagnostic accuracy between the HAS-BLED score and any of HEMORR2 HAGES, ATRIA, CHADS2 , or CHA2 DS2 -VASc scores in anticoagulated patients with atrial fibrillation. We systematically searched the Cochrane Library, MEDLINE, PubMed, and Embase databases for relevant studies. Data were extracted and analyzed according to predefined clinical endpoints. Eleven studies were identified. Discrimination analysis demonstrates that HAS-BLED has no significant C-statistic differences for bleeding risk prediction compared with ATRIA or HEMORR2 HAGES, but it has significant differences compared with CHADS2 or CHA2 DS2 -VASc. The significant positive net reclassification improvement and integrated discrimination improvement values also show that HAS-BLED is superior to that of any of HEMORR2 HAGES, ATRIA, CHADS2 , or CHA2 DS2 -VASc scores. According to calibration analysis of HAS-BLED, it overpredicts the risk of bleeding in the low (risk ratio [RR]: 1.16, 95% confidence interval [CI]: 0.63-2.13, P = 0.64) risk stratification but underpredicts that in the moderate (RR: 0.66, 95% CI: 0.51-0.86, P = 0.002) and high (RR: 0.88, 95% CI: 0.70-1.10, P = 0.27) risk stratifications. The HAS-BLED score not only performs better than the HEMORR2 HAGES and ATRIA bleeding scores, but it also is superior to the CHADS2 and CHA2 DS2 -VASc stroke scores for bleeding prediction. The HAS-BLED score should be the optimal choice to assess major bleeding risk in clinical practice.

show abstract

Section: Resultsmentioning

confidence: 99%

The HAS‐BLED Score for Predicting Major Bleeding Risk in Anticoagulated Patients With Atrial Fibrillation: A Systematic Review and Meta‐analysis

Zhu

Guo

et al. 2015

Clinical Cardiology

168

View full text Add to dashboard Cite

show abstract

“…As a comparison, the well-known CHADS2 and CHADS2-VASC scores for stroke risk stratification in atrial fibrillation, and the HAS-BLED score for bleeding risk on anticoagulation all have a C-statistic of 0.68 or less in external validation studies. 22-25 …”

Section: Discussionmentioning

confidence: 99%

International Validity of the HOSPITAL Score to Predict 30-Day Potentially Avoidable Hospital Readmissions

et al. 2016

View full text Add to dashboard Cite

“…complexity of treated CAD, amount of disease left untreated, technical considerations regarding stent implantation techniques, and results) as well as the bleeding risks. While ischaemic risk scores also predict bleeding outcomes in AF, 187 suggesting considerable overlap among risk factors associated with ischaemic and bleeding outcomes, multiple bleeding risk scores, 188 including the HAS-BLED Importantly, HAS-BLED draws attention to the reversible bleeding risk factors to be addressed by the responsible clinician during the follow-up. Risk is not static and, particularly for bleeding, many risk factors can be modified.…”

mentioning

confidence: 99%

2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS

Valgimigli¹,

Bueno²,

Byrne³

et al. 2017

European Heart Journal

2,285

484

View full text Add to dashboard Cite

The Predictive Ability of the CHADS2 and CHA2DS2-VASc Scores for Bleeding Risk in Atrial Fibrillation: The MAQI2 Experience

Cited by 33 publications

References 39 publications

The HAS‐BLED Score for Predicting Major Bleeding Risk in Anticoagulated Patients With Atrial Fibrillation: A Systematic Review and Meta‐analysis

The HAS‐BLED Score for Predicting Major Bleeding Risk in Anticoagulated Patients With Atrial Fibrillation: A Systematic Review and Meta‐analysis

International Validity of the HOSPITAL Score to Predict 30-Day Potentially Avoidable Hospital Readmissions

2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS

Contact Info

Product

Resources

About