Analysis of clinical evaluation of response to treatment of Parkinson’s disease with integrated Chinese and Western medicine therapy

Abstract

The six assessed means of clinical evaluation (including UPDRS II and UPDRS III scores, sleep scale score, getting up time, 10 m×2 times, and turning time) are sensitive indexes in all PD patients. H-Y stage and Madopar dosage are the major factors influencing means of clinical assessment of PD treatment.

Nurr1‐Based Therapies for Parkinson's Disease

“…In addition to activate Nurr1 by recognition on the specific target region of Nurr1, some other compounds, such as DA agonists, memantine, retinoic acid-loaded polymeric nanoparticles (RA-NPs) and herbal extracts (as summarized in Table 2), have also been demonstrated to up-regulate Nurr1 expression in preclinical trials of PD treatment although there have not any report to confirm that they can activate Nurr1 by direct binding [63, 66, 70–73, 78]. …”

“…Besides those chemically synthesized compounds, several Nurr1-modulators from natural source, such as moracenin D, EGb 761, radicicol and Bushen Huoxue Decoction (BHD), are also effective in PD therapy [70–73]. Moracenin D, an extract from Mori Cortex radices, significantly up-regulates Nurr1 expression and down-regulates α-synuclein expression [70].…”

“…It has been reported that the medical decoction BHD could also increase Nurr1 expression. The anti-parkinsonian effect of BHD has been tested in clinical trials [73,76]. …”

“…Although the specific mechanisms for the Nurr1 up-regulating effects of the above mentioned compounds, natural products and biomaterials still remain poorly understood, those candidates have a common feature to promote Nurr1 expression or functions, and part of those candidates have been shown to exert potent anti-parkinsonian properties in clinic [66, 73]. Further exploration of those modulators should focus on identifying their direct binding regions to Nurr1 and the Nurr1 upstream molecules.…”

Acupuncture for motor symptom improvement in Parkinson's disease and the potential identification of responders to acupuncture treatment

“…In a previous study, H-Y stage and age were predictive of the effects of integrated Chinese and western therapy as evaluated using the UPDRS III score. 11 The authors thus hypothesize that the severity of PD is a determinant of EA treatment response. Another subgroup analysis revealed that participants with tremor type PD did not improve following treatment.…”