Chronic stress induces steatohepatitis while decreases visceral fat mass in mice

Liu, Yun-Zi; Chen, Ji-Kuai; Zhang, Yi; Wang, Xia; Qu, Shen; Jiang, Chun‐Lei

doi:10.1186/1471-230x-14-106

Cited by 38 publications

(35 citation statements)

References 28 publications

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“…Although simple hepatic steatosis is a slowly developing asymptomatic disease, the next stage, non-alcoholic steatohepatitis (NASH), is more likely to cause progressive cirrhosis and hepatocellular carcinoma, resulting in increased mortality [69]. It seems that chronic stress is directly linked to NAFLD and chronic inflammation in visceral fat [70]. Under normal dietary conditions, chronic stress induces noticeable hepatic oxidative stress and inflammation without causing manifest hepatocellular injury.…”

Section: Muscle Mass: Myosteatosis and Sarcopeniamentioning

confidence: 99%

Chronic stress and body composition disorders: implications for health and disease

Stefanaki

Pervanidou

Boschiero³

et al. 2018

Hormones

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Recent studies have suggested that body composition is key to health and disease. First, fat tissue is a complex, essential, and highly active metabolic and endocrine organ that responds to afferent signals from traditional hormone systems and the central nervous system but also expresses and secretes factors with important endocrine, metabolic, and immune functions. Second, skeletal muscle mass is an important predictor of health in adult life, while severe mass loss has been associated with the frailty of old age. Studies have shown that skeletal muscle is also an important endocrine organ that secretes factors with autocrine, paracrine, or endocrine actions, which have been associated with inflammatory processes. Third, the bone is also a systemic endocrine regulator playing a pivotal role in health and disease. Finally, proper hydration in humans has been neglected as a health factor, especially in adults. Chronic stress and stress hormone hypersecretion alone or associated with distinct disorders, such as anxiety, depression, obesity, metabolic syndrome, autoimmune disorders, type 2 diabetes mellitus, and polycystic ovary syndrome (PCOS), have been associated with psychological and somatic manifestations, typically, increased fat mass, osteosarcopenia/frailty, cellular dehydration, and chronic systemic inflammation. This review aims to provide new insights into the newly developed concept of stress-related osteosarcopenic obesity and its prevention.

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Section: Muscle Mass: Myosteatosis and Sarcopeniamentioning

confidence: 99%

Chronic stress and body composition disorders: implications for health and disease

Stefanaki

Pervanidou

Boschiero³

et al. 2018

Hormones

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“…It is also characterized by the activation of the autonomic nervous system, hypothalamic-pituitary-adrenal axis, and sympathetic-adrenal-medullary system [14]. In modern society, which is characterized by a rapid pace of life, individuals ceaselessly encounter an increasing number of psychological stressful stimuli such as emotional stimuli and social stress [15]. It had been validated by clinical trials that chronic stress from high levels of working pressure and a low quality of life are the risk factors of obesity and metabolism syndrome [16, 17].…”

Section: Introductionmentioning

confidence: 99%

Effect of traditional Chinese medicine formula Sinisan on chronic restraint stress-induced nonalcoholic fatty liver disease: a rat study

Cheng

Wang

et al. 2017

BMC Complement Altern Med

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BackgroundNonalcoholic fatty liver disease (NAFLD) represents one of the most common forms of liver disease worldwide, and it is always regarded as a consequence of a sedentary, food-abundant lifestyle, sitting for an extended time, and a low physical activity level, which often coincide with chronic and long-lasting psychological stress. A Chinese medicine Sinisan (SNS) may be a potential formula for treating this kind of disease.MethodsIn this study, a long-term chronic restraint stress protocol was used to investigate the mechanism underlying stress-induced NALFD. To investigate the effect of SNS treatment on stress-induced NAFLD, we measured the liver and serum values of total cholesterol (TC), triglyceride (TG), liver free fatty acids (FFA), low-density lipoprotein, superoxide dismutase, tumor necrosis factor-α, malondialdehyde, interleukin (IL)-6, and serum values of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase. Results are shown as a mean ± standard deviation. Significant differences between the groups were evaluated using the Student t-test. For multiple comparisons, one-way analysis of variance (ANOVA) was used. If the results of ANOVA indicated significant differences, post hoc analysis was performed with the Tukey test or Dunnett test, and p < 0.05 was considered statistically significant.ResultsLong-term chronic stress led to steatosis and non-alcoholic steatohepatitis. Additionally, SNS treatment significantly increased body weight gain (p < 0.01) and sucrose preference (p < 0.001), and it reduced the liver values of TC, TG, and FFA (p < 0.05). SNS also reduced the serum values of AST and ALT (p < 0.001), and the liver value of IL-6 (p < 0.01).ConclusionsThis study’s results demonstrate that psychological stress may be a significant risk factor of NAFLD. Furthermore, the traditional Chinese medicine formula SNS may have some beneficial effect in antagonizing psychological stress and stress-related NAFLD.

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“…This possibility is supported by observations of an enhanced expression of different pro-inflammatory cytokines by visceral adipose tissue in a rodent experimental model of stress-induced steatohepatitis (Liu et al, 2014). In addition to stress, liver steatosis can be related to endocrine, nutritional, or metabolic disorders, as well as other inflammatory diseases of the liver, pancreas and adjacent structures (Richter, 2005).…”

Section: Resultsmentioning

confidence: 84%

Hepatic steatosis in six-banded armadillo (Euphractus sexcinctus Linnaeus, 1758)

et al. 2018

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The six-banded armadillo (Euphractus sexcinctus) stands out among wild mammals due to the rare occurrence of spontaneous metabolic diseases. When altered, the liver, which is important in metabolism, may trigger a dysfunctional cascade, leading to hepatic steatosis. Here we describe a case of hepatic steatosis in a six-banded armadillo living in captivity. The female specimen was captured and donated to the Federal University of Piaui under SISBIO authorization nº53303. The animal was first referred for a veterinary clinical evaluation, and then euthanized following the ethical standards of the Federal Council of Veterinary Medicine. At the start of the dissection, the abdominal cavity was accessed and sections of all ex situ liver lobes, spleen and mandibular lymph node were subjected to routine histological processing; the results were photo documented. The anatomic and histopathological analysis confirmed the diagnosis of hepatic steatosis, which we propose is related to an infectious process as a result of the changes observed in the organs of the lymphoid system. This report of fatty liver disease in armadillo suggests an acute infectious process with lymphoid system involvement. Keywords: Euphractus sexcinctus, infectious, liver, six-banded armadillo, steatosis. Esteatose hepática em tatu-peba (Euphractus sexcinctus Linnaeus, 1758)Resumo: O tatu-verdadeiro (Euphractus sexcinctus) se destaca entre os mamíferos selvagens devido à rara ocorrência de doenças metabólicas espontâneas. Quando alterado, o fígado, que é importante no metabolismo, pode desencadear uma cascata disfuncional, levando a esteatose hepática. Foi descrito um caso de esteatose hepática em um tatu-verdadeiro vivendo em cativeiro. O espécime feminino foi capturado e doado para a Universidade Federal do Piauí sob a autorização SISBIO nº53303. O animal foi encaminhado para uma avaliação clínica veterinária e, depois, submetido à eutanásia seguindo os padrões éticos do Conselho Federal de Medicina Veterinária. No início da dissecção, acessou-se a cavidade abdominal e as seções de todos os lóbulos do fígado ex situ, do baço e do linfonodo mandibular foram submetidos ao processamento histológico de rotina. Os resultados foram fotomicrografados e documentados. A análise anatômica e histopatológica confirmou o diagnóstico de esteatose hepática, que está relacionada a um processo infeccioso como resultado das mudanças observadas nos órgãos do sistema linfóide. Este relatório de doença hepática gordurosa no armadillo sugere um processo infeccioso agudo com comprometimento do sistema linfático. Euphractus sexcinctus, infecção, fígado, tatu-verdadeiro, esteatose. Palavras-chaves:

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Chronic stress induces steatohepatitis while decreases visceral fat mass in mice

Cited by 38 publications

References 28 publications

Chronic stress and body composition disorders: implications for health and disease

Chronic stress and body composition disorders: implications for health and disease

Effect of traditional Chinese medicine formula Sinisan on chronic restraint stress-induced nonalcoholic fatty liver disease: a rat study

Hepatic steatosis in six-banded armadillo (Euphractus sexcinctus Linnaeus, 1758)

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