Neighboring Look-A-Likes

Desman, Garrett; Özerdem, Uğur; Shin, Sandra J.

doi:10.1097/pap.0000000000000025

Cited by 3 publications

(2 citation statements)

References 116 publications

(117 reference statements)

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“…Histopathologically, PCACCs consist of basaloid cells, which are arranged as cribriform nests, tubules, cords, and solid areas in the dermis and subcutis [ 1 , 29 ]. The luminal areas usually consist of alternating eosinophilic or basophilic secretions [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

Two Different Cell Populations Is an Important Clue for Diagnosis of Primary Cutaneous Adenoid Cystic Carcinoma: Immunohistochemical Study

Alkan

Bozdoğan

Karadeniz

et al. 2017

Case Reports in Pathology

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Primary cutaneous adenoid cystic carcinoma (PCACC) is a very rare malignancy. The differential diagnosis of PCACCs in pathology practice can be difficult and a group of primary and metastatic lesions, including adenoid basal cell carcinoma of the skin, should be considered in the differential diagnosis. Besides histomorphological clues, immunohistochemistry studies are very helpful in the differential diagnosis of PCACC. We report herein a case of PCACC with extensive immunohistochemical studies and review the literature from an immunohistochemistry perspective.

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Section: Discussionmentioning

confidence: 99%

Two Different Cell Populations Is an Important Clue for Diagnosis of Primary Cutaneous Adenoid Cystic Carcinoma: Immunohistochemical Study

Alkan

Bozdoğan

Karadeniz

et al. 2017

Case Reports in Pathology

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“…Due to the proximity of the skin and subcutis to the breast, the possibility of a “breast mass” actually representing a dermatologic lesion should be considered, particularly if the proliferation does not look characteristically “mammary” in appearance [ 1 , 2 ]. One such “breast mass” is eccrine spiradenoma of skin.…”

Section: Introductionmentioning

confidence: 99%

Eccrine Spiradenoma Arising from the Breast Skin

Benedict

Özerdem

2015

Case Reports in Pathology

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Eccrine spiradenomas are uncommon, benign lesions, which are thought to originate from the eccrine sweat glands. They are common in young adults and are without a sex predilection. Here we report a case of eccrine spiradenoma of the breast skin in a 39-year-old woman who presented with a breast nodule for 10 years. It is crucial to take eccrine spiradenoma into consideration in superficial, well-circumscribed, breast skin/subcutaneous lesions. It is useful to recognize the two-cell populations constituting this tumor: small, dark, basaloid cells with hyperchromatic nuclei, which are immunoreactive for P63 and calponin, and larger cells with a pale nucleus, often near the center of the cluster (inner cells), which are immunoreactive for CK7 and CD117 (C-kit).

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A clinical, pathological and immunohistochemical series of 9 cases of primary cutaneous apocrine carcinomas of the head and neck

Portelli

Projetto

Gori³

et al. 2019

Aust J Dermatology

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Background/Objectives: Primary cutaneous apocrine carcinoma is a rare malignant adnexal skin tumour that can recur locally, spread to regional lymph nodes and metastatize to visceral organs. Wide dissemination and death from disease are much less common. The axilla is the most common site of presentation. It is infrequently reported in the head and neck region.Methods: All cases diagnosed as primary cutaneous apocrine carcinoma of the head and neck were retrospectively collected from the archives of the Division of Pathological Anatomy, University of Florence from 1996 to 2016. There was no history or clinical evidence of breast cancer. Clinical data and followup were collected by the clinicians.Results: Nine cases were found, with a mean age of 76 years, ranging in size between 0.3 and 3.5 cm. Clinically, they were frequently mistaken for basal cell carcinomas. Histopathologically, all the tumours showed decapitation secretion, a tubular, solid or mixed (tubulo-papillary and solid-tubular) growth pattern and were predominantly classified as grade 2 tumours. GCDFP-15 and hormone receptors were variably expressed. HER2 and podoplanin were negative in all cases.In one case, spreading to regional lymph nodes was observed. No cases were associated with death due to the disease. Conclusion:As immunohistochemical analysis lacks specificity in distinguishing primary cutaneous apocrine carcinoma from a cutaneous metastasis of breast carcinoma, detailed clinical history, breast examination, adequate treatment and follow-up are necessary to confirm a diagnosis of primary cutaneous apocrine carcinoma.

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Neighboring Look-A-Likes

Cited by 3 publications

References 116 publications

Two Different Cell Populations Is an Important Clue for Diagnosis of Primary Cutaneous Adenoid Cystic Carcinoma: Immunohistochemical Study

Two Different Cell Populations Is an Important Clue for Diagnosis of Primary Cutaneous Adenoid Cystic Carcinoma: Immunohistochemical Study

Eccrine Spiradenoma Arising from the Breast Skin

A clinical, pathological and immunohistochemical series of 9 cases of primary cutaneous apocrine carcinomas of the head and neck

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