Enterovirus infections are associated with white matter damage in neonates

Fan, Xiaoping; Wang, Wei-Yan; Yuan, Tianming

doi:10.1111/jpc.12656

Cited by 30 publications

(29 citation statements)

References 14 publications

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“…The pattern of WMI seen in rotavirus infections is not unique and is, in fact, strikingly similar to that seen in neonatal enterovirus and parechovirus encephalitis11293031323334). In all 3 infections, the major findings on cerebral imaging are diffuse high signal intensity in the white matter on T2-weighted sequences and restricted diffusion in the periventricular white matter, corpus callosum, and deep white matter.…”

Section: Comparisons With Other Viral Infectionsmentioning

confidence: 58%

White matter injury following rotavirus infection in neonates: new aspects to a forgotten entity, 'fifth day fits'?

Yeom

Park

2016

Korean J Pediatr

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That rotavirus infection can cause neurological symptoms in young children has been well established. However, it is surprising why rotavirus infection has been overlooked as a cause of neonatal seizures for many years, despite significant research interest in neonatal rotavirus infection. Neonates are the age group most vulnerable to seizures, which are typically attributed to a wide range of causes. By contrast, because rotavirus infection is usually asymptomatic, it has been difficult to identify an association between this virus and neonatal seizures. The conventional wisdom has been that, although neonates are commonly infected with rotavirus, neurological complications are rare in this age. However, recent studies using diffusion-weighted imaging (DWI) have suggested a connection between rotavirus infection and neonatal seizures and that rotavirus infection can induce diffuse white matter injury without direct invasion of the central nervous system. The clinical features of white matter injury in rotavirus-infected neonates include the onset of seizures at days 4–6 of life in apparently healthy term infants. The recent findings seem to contradict the conventional wisdom. However, white matter injury might not be a completely new aspect of rotavirus infection in neonates, considering the forgotten clinical entity of neonatal seizures, 'fifth day fits'. With increased use of DWI in neonatal seizures, we are just starting to understand connection between viral infection and white matter injury in neonates. In this review, we discuss the historical aspects of rotavirus infection and neonatal seizures. We also present the clinical features of white matter injury in neonatal rotavirus infection.

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Section: Comparisons With Other Viral Infectionsmentioning

confidence: 58%

White matter injury following rotavirus infection in neonates: new aspects to a forgotten entity, 'fifth day fits'?

Yeom

Park

2016

Korean J Pediatr

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“…The MRI changes in HPeV encephalitis are, however, not specific. Similar changes have been described in neonatal enterovirus 42,43 where, interestingly, an absence of CSF pleocytosis often occurs. 16,40 Furthermore, these imaging findings are reminiscent of perinatal WM injury from other causes that are known to result in periventricular leukomalacia and a high risk of cerebral palsy.…”

Section: ; Nil/minor Sequelae Signifi Cant Concernmentioning

confidence: 59%

Parechovirus Encephalitis and Neurodevelopmental Outcomes

et al. 2016

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“…Patients who met the following criteria were recruited in the present study: age above 1 month and less than 14 years old, the children who visited our hospital during the study period, and primarily diagnosed with encephalitis by pediatric neurologists as our previous report. [13] This study was approved by the medical ethics committee of the Children's Hospital of Zhejiang University School of Medicine, and informed consent was obtained from patients' parents or legal guardians.…”

Section: Subjectsmentioning

confidence: 99%

“…The detection of EVs in ABI Stepone plus system was performed by using commercial one-step real-time RT-PCR assay kit (Zhi-jiang company). [13] The real time RT-PCR was conducted under these conditions: 15 minutes at 50°C, 5 minutes at 95°C, and then followed by 40 cycles of 15 seconds at 94°C and 45 seconds at 55°C. Samples with CT value less than 35.0 were identified positive.…”

Section: Detection Of Enterovirusmentioning

confidence: 99%

“…[6,[10][11][12][13] Due to the large number of EV serotypes and their diverse clinical presentations, we think that it is necessary to find the major serotype of the EV timely and take step immediately to interrupt transmission. Above all, we aim to know more about the clinical characteristics of EVE patients and find out which serotype of EV plays a major role in EVE infection in this study.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Molecular epidemiological study of enteroviruses associated with encephalitis in children from Hangzhou, China

2016

Medicine

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Enterovirus (EV) has over 100 serotypes of species A-D, which can cause various symptoms in infants. Enterovirus encephalitis (EVE) is serve disease with high morbidity and mortality in children. To well define the epidemiology of EVE, we wanted to know more about EV and EV molecular typing by conducting this study in Hangzhou.Cerebrospinal fluid samples were collected from children with diagnosis of encephalitis. Meanwhile, one-step real-time RT-PCR was used for the detection of EV, and we also identified the serotypes of EV by using gene sequencing of VP1 or 5 0 UTR region. A total of 126 CSF specimens were tested and EV was detected in 26 specimens (20.6%). The molecular typing results showed different types of EV strains including Coxsackievirus B2, Coxsackievirus B3, Echovirus 5, Echovirus 16, Echovirus 18, Echovirus 30, and all EV isolates belonging to the human EV species B.According to the sequence of VP1 and 5 0 UTR region, E30 may be major cause of children's EVE in Hangzhou, China.Abbreviations: CSF = cerebrospinal fluid, EV = enterovirus, EVE = enterovirus encephalitis, GLU = glucose, RT-PCR = reverse transcription-polymerase chain reaction.

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Enterovirus infections are associated with white matter damage in neonates

Abstract: Enterovirus may cause severe central nervous system infection in the neonatal period. The neuroimaging studies are informative and should be a part of care for infants with enteroviruses.

Cited by 30 publications

References 14 publications

White matter injury following rotavirus infection in neonates: new aspects to a forgotten entity, 'fifth day fits'?

White matter injury following rotavirus infection in neonates: new aspects to a forgotten entity, 'fifth day fits'?

Parechovirus Encephalitis and Neurodevelopmental Outcomes

Molecular epidemiological study of enteroviruses associated with encephalitis in children from Hangzhou, China

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