Non-union site debridement increased the efficacy of rhBMP-2 in a rodent model

Schützenberger, Sebastian; Kaipel, Martin; Schultz, A.; Nau, Thomas; Redl, Heinz; Hausner, T.

doi:10.1016/j.injury.2014.05.004

Cited by 15 publications

(4 citation statements)

References 20 publications

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“…We thus loaded the CPC scaffold with 10 µg of rh-BMP-2 to overcome its lack of osteoinductive properties. This dosage is consistent with previous studies of critical-sized femoral defect of 3 to 6 mm in rats [53,54,[54][55][56]. However, further studies would be necessary to assess the release kinetics and the dose-response of BMP-2 on the CPC to improve the system.…”

Section: Discussionsupporting

confidence: 89%

“…Despite the low dose of BMP-2, the barrier membrane effect appears to have been masked by the effect of the growth factor. The association of BMP-2 and a bone substitute to fill a rat segmental defect using a two-step surgical approach has only been investigated in one study [53]. Interestingly, they observed a significant higher level of bone formation when they performed a debridement of the IM before filling the defect, therefore suggesting an inhibition of the effect of BMP-2 by the IM.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of amniotic membrane versus the induced membrane for bone regeneration in long bone segmental defects using calcium phosphate cement loaded with BMP-2

Fénelon

Etchebarne

Siadous

et al. 2021

Materials Science and Engineering: C

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Comparison of amniotic membrane versus the induced membrane for bone regeneration in long bone segmental defects using calcium phosphate cement loaded with BMP-2

Fénelon

Etchebarne

Siadous

et al. 2021

Materials Science and Engineering: C

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“…25,26 Bone may require additional stimulation to facilitate healing, such as, surgical debridement at the fracture edge or intramedullary reaming to stimulate bleeding at fracture edges. 27 Clinically, fracture-related infections imparts significant morbidity for patients at a substantial time cost, without guarantee of a positive outcome.…”

Section: Clinical Challengesmentioning

confidence: 99%

The intersection of fracture healing and infection: Orthopaedics research society workshop 2021

Hellwinkel

Working

Certain

et al. 2022

Journal Orthopaedic Research

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Infection is a common cause of impaired fracture healing. In the clinical setting, definitive fracture treatment and infection are often treated separately and sequentially, by different clinical specialties. The ability to treat infection while promoting fracture healing will greatly reduce the cost, number of procedures, and patient morbidity associated with infected fractures. In order to develop new therapies, scientists and engineers must understand the clinical need, current standards of care, pathologic effects of infection on fractures, available preclinical models, and novel technologies. One of the main causes of poor fracture healing is infection; unfortunately, bone regeneration and infection research are typically approached independently and viewed as two separate disciplines. Here, we aim to bring these two groups together in an educational workshop to promote research into the basic and translational science that will address the clinical challenge of delayed fracture healing due to infection. Statement of clinical significance: Infection and nonunion are each feared outcomes in fracture care, and infection is a significant driver of nonunion. The impact of nonunions on patie[Q2]nt well-being is substantial. Outcome data suggests a long bone nonunion is as impactful on healthrelated quality of life measures as a diagnosis of type 1 diabetes and fracture-related infection has been shown to significantly l[Q3]ower a patient's quality of life for over 4 years. Although they frequently are associated with one another, the treatment approaches for infections and nonunions are not always complimentary and cannot be performed simultaneously without accepting tradeoffs. Furthermore, different

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“…The intense research in this field seen over the last few decades, has resulted in the discovery of several proteins that can upregulate the bone healing response [ 14 , 15 ]. Bone morphogenetic proteins (BMPs) are the most representative example, which have been granted US Food and Drug Administration (FDA) approval for clinical applications in recalcitrant long bone non-unions, lumbar fusion and open tibial shaft fractures [ 16 – 18 ]. Several other proteins have shown to upregulate the osteogenic bone healing process [ 19 – 22 ].…”

Section: Introductionmentioning

confidence: 99%

The role of peptides in bone healing and regeneration: a systematic review

Pountos

Panteli

Lampropoulos

et al. 2016

BMC Med

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BackgroundBone tissue engineering and the research surrounding peptides has expanded significantly over the last few decades. Several peptides have been shown to support and stimulate the bone healing response and have been proposed as therapeutic vehicles for clinical use. The aim of this comprehensive review is to present the clinical and experimental studies analysing the potential role of peptides for bone healing and bone regeneration.MethodsA systematic review according to PRISMA guidelines was conducted. Articles presenting peptides capable of exerting an upregulatory effect on osteoprogenitor cells and bone healing were included in the study.ResultsBased on the available literature, a significant amount of experimental in vitro and in vivo evidence exists. Several peptides were found to upregulate the bone healing response in experimental models and could act as potential candidates for future clinical applications. However, from the available peptides that reached the level of clinical trials, the presented results are limited.ConclusionFurther research is desirable to shed more light into the processes governing the osteoprogenitor cellular responses. With further advances in the field of biomimetic materials and scaffolds, new treatment modalities for bone repair will emerge.

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Non-union site debridement increased the efficacy of rhBMP-2 in a rodent model

Cited by 15 publications

References 20 publications

Comparison of amniotic membrane versus the induced membrane for bone regeneration in long bone segmental defects using calcium phosphate cement loaded with BMP-2

Comparison of amniotic membrane versus the induced membrane for bone regeneration in long bone segmental defects using calcium phosphate cement loaded with BMP-2

The intersection of fracture healing and infection: Orthopaedics research society workshop 2021

The role of peptides in bone healing and regeneration: a systematic review

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