P selectin and T cell profiles provide verification to understand the pathogenesis of liver cirrhosis in HCV and Schistosoma mansoni infections

Kamel, Mahmoud M.; Romeyia, Salah A.; Ali, Mohamed I. Hassan; Aziz, Heisham A.; Abdel‐Moneim, Ahmed S.

doi:10.1016/j.micpath.2014.05.006

Cited by 4 publications

(4 citation statements)

References 38 publications

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“…Both this study and another documented lower HCV-specific CD4 + proliferative responses to HCV antigens in those with HCV-schistosome coinfection [ 20 , 21 ]. Two others reported no differences in CD4 + or CD8 + T cells, [ 22 ] or in CD4 + or CD8 + granzyme B + effector T cells, although granzyme B + effector T regs were increased in coinfection [ 23 ]. The fifth study reported fewer late differentiated HCV-specific memory T cells in coinfected individuals compared to those with HCV alone [ 24 ].…”

Section: Resultsmentioning

confidence: 99%

“…Six studies investigated circulating T cells in HCV-schistosome coinfected individuals compared to those with HCV alone [20][21][22][23][24]. In one of these, S. mansoni-infected patients who acutely acquired HCV developed a Th2 and T reg-dominant response and 17/17 failed to clear HCV, while those without S. mansoni infection developed a Th1-dominant response and 5/15 cleared HCV infection [20].…”

Section: Hepatitis B and C Virusesmentioning

confidence: 99%

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Effects of schistosomes on host anti-viral immune response and the acquisition, virulence, and prevention of viral infections: A systematic review

et al. 2021

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Although a growing number of studies suggest interactions between Schistosoma parasites and viral infections, the effects of schistosome infections on the host response to viruses have not been evaluated comprehensively. In this systematic review, we investigated how schistosomes impact incidence, virulence, and prevention of viral infections in humans and animals. We also evaluated immune effects of schistosomes in those coinfected with viruses. We screened 4,730 studies and included 103. Schistosomes may increase susceptibility to some viruses, including HIV and Kaposi’s sarcoma-associated herpesvirus, and virulence of hepatitis B and C viruses. In contrast, schistosome infection may be protective in chronic HIV, Human T-cell Lymphotropic Virus-Type 1, and respiratory viruses, though further research is needed. Schistosome infections were consistently reported to impair immune responses to hepatitis B and possibly measles vaccines. Understanding the interplay between schistosomes and viruses has ramifications for anti-viral vaccination strategies and global control of viral infections.

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Section: Resultsmentioning

confidence: 99%

Section: Hepatitis B and C Virusesmentioning

confidence: 99%

Effects of schistosomes on host anti-viral immune response and the acquisition, virulence, and prevention of viral infections: A systematic review

et al. 2021

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“…Kamel et al . [ 17 ] also reported that plasma soluble P-selectin level was markedly elevated in chronic HCV especially in patients with low platelet counts with a direct correlation with serum HCV-RNA. Guzmán-Fulgencio et al .…”

Section: Discussionmentioning

confidence: 99%

CD62P (P-selectin) expression as a platelet activation marker in patients with liver cirrhosis with and without cholestasis

Hegazy¹,

Elsabaawy²,

Eltabakh³

et al. 2021

ceh

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“…Cytokines IL-6 and IL-8 are the diagnostic indicators of inflammation and DVT. Both IL-2 and P-selectin mediate CD8 + T cells [ 39 , 40 ], and both IL-2 and GPIIb/IIIa are involved in the immune thrombocytopenia related CD8 + T cells [ 41 ]. These correlations led to the measurement of IL-2, IL-6 and IL-8 in the serum of the mice receiving xylene-induced ear edema assay.…”

Section: Discussionmentioning

confidence: 99%

IQCA-TAVV: To explore the effect of P-selectin, GPIIb/IIIa, IL-2, IL-6 and IL-8 on deep venous thrombosis

Zhu

Yang

et al. 2017

Oncotarget

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Deep vein thrombosis (DVT) associates with considerable morbidity, functional disability and mortality. Due to the lack of suitable inhibitor the correlation of various factors in DVT onset remains unknown. In this context we analyzed the structure of anti-platelet aggregation agent, P-selectin down-regulator, GPIIb/ IIIa down-regulator and anti-inflammatory agent, thereby designed N-(3S-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-Thr-Ala-Arg-Gly-Asp(Val)-Val (IQCA-TAVV) as an inhibitor of DVT to receive evaluations. The docking predicted that IQCA-TAVV can target P-selectin and GPIIb/IIIa. The UV showed that IQCA-TAVV can act on P-selectin and GPIIb/IIIa. ELISA indicated that IQCA-TAVV concentration dependently inhibited activated platelets to express P-selectin and GPIIb/IIIa, and the minimal effective concentration was 1 nM. IC 50 of IQCA-TAVV against platelet aggregation induced by arachidonic acid, adenosine diphosphate and platelet activating factor fell within a range of 0.13 nM to 0.30 nM. In vivo IQCA-TAVV dose-dependently inhibited venous thrombosis and the minimal effective dose was 1 nmol/kg. On ear edema model the anti-inflammation activity of 10 nmol/kg IQCA-TAVV equaled that of 1.1mmol/kg aspirin. The concentration of IL-2, IL-6 and IL-8 in the serum of the ear edema mice were also significantly decreased by 10 nmol/kg IQCA-TAVV. Even at 1 μmol/kg of dose IQCA-TAVV still did not injure the kidney, the liver, and the nerves of healthy mice. Thereby IQCA-TAVV depicts a relationship of three levels (inhibiting platelet activation, targeting externalized membrane receptor, decreasing serum inflammatory factor) for the down-regulation of P-selectin, GPIIb/IIIa, IL-2, IL-6 and IL-8 in DVT.

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P selectin and T cell profiles provide verification to understand the pathogenesis of liver cirrhosis in HCV and Schistosoma mansoni infections

Cited by 4 publications

References 38 publications

Effects of schistosomes on host anti-viral immune response and the acquisition, virulence, and prevention of viral infections: A systematic review

Effects of schistosomes on host anti-viral immune response and the acquisition, virulence, and prevention of viral infections: A systematic review

CD62P (P-selectin) expression as a platelet activation marker in patients with liver cirrhosis with and without cholestasis

IQCA-TAVV: To explore the effect of P-selectin, GPIIb/IIIa, IL-2, IL-6 and IL-8 on deep venous thrombosis

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