Synthesis and preliminary evaluation of novel 99mTc-labeled folate derivative via click reaction for SPECT imaging

Superfluorinated PEI Derivative Coupled with 99mTc for ASGPR Targeted 19F MRI/SPECT/PA Tri‐Modality Imaging

“…[25][26][27] 99m Tc is the most widely used radioisotope for SPECT imaging because of its ideal physical properties (Half-life: 6.02 h, γ-Energy: 141 keV (89 %)) and easy availability by a generator system. [28,29] In general, reduced 99m Tc can be combined with a bifunctional chelating agent, such as DTPA (diethylenetriaminepentaacetic acid) and HYNIC (2-hydrazinonicotinic acid), or other chemical groups (such as COO − , OH, NH 2 , and SH). PEI is known for its potential in eliminating metal ions from wastewater by coordination of metal ions with secondary or tertiary amino groups in PEI.…”

Synthesis and evaluation of 68Ga‐HBED‐CC‐EDBE‐folate for positron‐emission tomography imaging of overexpressed folate receptors on CT26 tumor cells

“…Folic acid (vitamin B 9 ), consisting of pteroic acid and glutamic acid, exhibits high affinity for folate receptors that are overexpressed on the surfaces of various cancer cells . Because folate receptors are almost never expressed on the surfaces of normal cells, folic acid can be used to selectively deliver drug compounds to target cancer cells .…”

In vivo MR imaging of folate-receptor expression with the folate-specific nanospheres in a C6 glioblastoma model

“…The folate receptor (FR) is strongly up-regulated in many solid tumor cells and endothelial cells of new vasculature in tumor tissues, while it is deficient in most normal organs, suggesting that it is a specific and potential binding target of interest [5,7].…”