Memantine prevents reference and working memory impairment caused by sleep deprivation in both young and aged Octodon degus

Tarragon, Ernesto; López, Dolores; Estrada, Cristina; González-Cuello, Ana; Ros, Carmen María Brugarolas; Lamberty, Yves; Pifferi, Fabien; Cella, Massimo; Canovi, Mara; Guiso, Giovanna; Gobbi, Marco; Fernández-Villalba, Emiliano; Blin, Olivier; Bordet, Régis; Richardson, Jill C.; Herrero, M.T.

doi:10.1016/j.neuropharm.2014.05.023

Cited by 21 publications

(11 citation statements)

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“…Interestingly, [ 50 ] showed that acute treatment with MEM improved working and spatial memory dysfunction in transgenic AD mice, which is in line with our findings. Also consistent with our results, a recent study by [ 68 ] investigated the effect of MEM on SD-induced cognitive impairment in Octodon degus , a rodent model that exhibits a natural occurrence of some AD-related neuropathologies. Their findings indicated that MEM was able to prevent reference and working memory impairment caused by SD in both young and aged animals.…”

Section: Discussionsupporting

confidence: 92%

Effects of acute administration of donepezil or memantine on sleep-deprivation-induced spatial memory deficit in young and aged non-human primate grey mouse lemurs (Microcebus murinus)

et al. 2017

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The development of novel therapeutics to prevent cognitive decline of Alzheimer's disease (AD) is facing paramount difficulties since the translational efficacy of rodent models did not resulted in better clinical results. Currently approved treatments, including the acetylcholinesterase inhibitor donepezil (DON) and the N-methyl-D-aspartate antagonist memantine (MEM) provide marginal therapeutic benefits to AD patients. There is an urgent need to develop a predictive animal model that is phylogenetically proximal to humans to achieve better translation. The non-human primate grey mouse lemur (Microcebus murinus) is increasingly used in aging research, but there is no published results related to the impact of known pharmacological treatments on age-related cognitive impairment observed in this primate. In the present study we investigated the effects of DON and MEM on sleep-deprivation (SD)—induced memory impairment in young and aged male mouse lemurs. In particular, spatial memory impairment was evaluated using a circular platform task after 8 h of total SD. Acute single doses of DON or MEM (0.1 and 1mg/kg) or vehicle were administered intraperitoneally 3 h before the cognitive task during the SD procedure. Results indicated that both doses of DON were able to prevent the SD-induced deficits in retrieval of spatial memory as compared to vehicle-treated animals, both in young and aged animals Likewise, MEM show a similar profile at 1 mg/kg but not at 0.1mg/kg. Taken together, these results indicate that two widely used drugs for mitigating cognitive deficits in AD were partially effective in sleep deprived mouse lemurs, which further support the translational potential of this animal model. Our findings demonstrate the utility of this primate model for further testing cognitive enhancing drugs in development for AD or other neuropsychiatric conditions.

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Section: Discussionsupporting

confidence: 92%

Effects of acute administration of donepezil or memantine on sleep-deprivation-induced spatial memory deficit in young and aged non-human primate grey mouse lemurs (Microcebus murinus)

et al. 2017

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“…Accurate performance requires subjects to learn and remember the location of the escape hole, therefore spatial cues (combination of different colours and shapes: a yellow star, a red square, and a green apple) were placed on the wall of the maze 62 . Briefly, the procedure was divided into three phases: habituation, training, and test phases, and was performed as previously described 58 , 63 . Session 1 (Habituation): began when the focal degu was placed into the escape box for 2 min.…”

Section: Methodsmentioning

confidence: 99%

Effects of long-lasting social isolation and re-socialization on cognitive performance and brain activity: a longitudinal study in Octodon degus

Rivera

Lindsay

Oliva

et al. 2020

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Social isolation is considered a stressful situation that results in increased physiological reactivity to novel stimuli, altered behaviour, and impaired brain function. Here, we investigated the effects of long-term social isolation on working memory, spatial learning/memory, hippocampal synaptic transmission, and synaptic proteins in the brain of adult female and male Octodon degus. The strong similarity between degus and humans in social, metabolic, biochemical, and cognitive aspects, makes it a unique animal model that can be highly applicable for further social, emotional, cognitive, and aging studies. These animals were socially isolated from post-natal and post-weaning until adulthood. We also evaluated if re-socialization would be able to compensate for reactive stress responses in chronically stressed animals. We showed that long-term social isolation impaired the HPA axis negative feedback loop, which can be related to cognitive deficits observed in chronically stressed animals. Notably, re-socialization restored it. In addition, we measured physiological aspects of synaptic transmission, where chronically stressed males showed more efficient transmission but deficient plasticity, as the reverse was true on females. Finally, we analysed synaptic and canonical Wnt signalling proteins in the hypothalamus, hippocampus, and prefrontal cortex, finding both sex- and brain structure-dependent modulation, including transient and permanent changes dependent on stress treatment.

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“…To evaluate the learning and memory of the animals, we used the Radial Arm Maze (RAM) (Tarragon et al, 2014). The apparatus consists in a platform with eight equidistantly spaced arms (42×12×12 cm 3 ).…”

Section: Radial Arm Mazementioning

confidence: 99%

“…On the other hand, the chronic TMS group received TMS in the retention session and in addition during the learning period ( Fig. 1 B) (Tarragon et al, 2014) …”

Section: Retention Session (Test) the Next Day After The Learning Pementioning

confidence: 99%

Cognitive Impairment After Sleep Deprivation Rescued by Transcranial Magnetic Stimulation Application in Octodon degus

et al. 2015

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Sleep is indispensable for maintaining regular daily life activities and a fundamental physiological purpose in cognitive performance. Sleep deprivation (SD) may affect subsequent learning capacity and ability to constitute new memories, particularly in the situation of hippocampusdependent tasks. Transcranial magnetic stimulation (TMS) is a non-invasive procedure of electromagnetic induction that generates electric currents activating nearby nerve cells in the stimulated cortical area. Several studies have begun to therapeutically use TMS. The present study was designed to evaluate how TMS could improve learning and memory functions after SD in O. degus. Thirty juvenile (aged eighteen months old) females were divided in three groups (control, acute and chronic TMS treatment -with and without SD). To immobilize TMS-treated groups, they were disposed in plastic cylindrical while the O. degus were receiving head magnetic stimulation. SD was achieved by gently handling the animals to keep them awake during the night. Behavioral tests include Radial Arm Maze (RAM), Barnes Maze (BM) and Novel Object Recognition (NOR). When TMS treatment was applied during several days, there was significant improvement of cognitive performance after SD. Noteworthy, only one session of TMS is able to improve some parameters related with spatial memory. No side effects were observed. After SD, chronic TMS treatment provokes significant amelioration in learning and in both spatial and working memory. Nonetheless, an acute treatment of TMS is already sufficient to improve spatial memory. To our knowledge, in this manuscript we confirm that sleep deprivation (SD) results in cognitive impairment measured with 3 different psychological tests, and we provide the evidence that transcranial magnetic stimulation (TMS) treatment significantly improve cognitive performance in sleep-deprived animals. Then, after SD, TMS can improve learning, spatial memory and working memory functions.We feel that these exciting results are novel and important, and can be of interest for scientists, neurologists and physicians working on sleep pathologies.The experimental work was done in compliance with the National Research Council's Guide for the care and use of laboratory animals, and the Guidelines promulgated by the European Communities Council Directive 2010/63/ECC.The data presented in the manuscript are original and the manuscript is not under consideration elsewhere. None of the manuscript contents has been previously published. In the present work we do not have any conflict of financial interest.All authors have seen and approved the manuscript.Trusting you will consider our manuscript worthy of review by your Journal, Yours truly, there was significant improvement of cognitive performance after SD. María-Trinidad HerreroNoteworthy, only one session of TMS is able to improve some parameters related with spatial memory. No side effects were observed. After SD, chronic TMS treatment provokes significant amelioration in learning and in both spat...

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Memantine prevents reference and working memory impairment caused by sleep deprivation in both young and aged Octodon degus

Cited by 21 publications

References 53 publications

Effects of acute administration of donepezil or memantine on sleep-deprivation-induced spatial memory deficit in young and aged non-human primate grey mouse lemurs (Microcebus murinus)

Effects of acute administration of donepezil or memantine on sleep-deprivation-induced spatial memory deficit in young and aged non-human primate grey mouse lemurs (Microcebus murinus)

Effects of long-lasting social isolation and re-socialization on cognitive performance and brain activity: a longitudinal study in Octodon degus

Cognitive Impairment After Sleep Deprivation Rescued by Transcranial Magnetic Stimulation Application in Octodon degus

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