Nivel de proteína C reactiva en pacientes con obesidad mórbida antes y después de cirugía bariátrica

Rojano-Rodríguez, Martín Edgardo; Valenzuela-Salazar, Carlos; Cárdenas-Lailson, Luis Eduardo; Loera, Luz Sujey Romero; Torres-Olalde, Mario Eduardo; Moreno-Portillo, Mucio

doi:10.1016/j.rgmx.2013.11.002

Cited by 11 publications

(5 citation statements)

References 20 publications

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“…Overall, several parameters determined in our patient cohort were comparable to already established results from bariatric surgery patients including a massive drop of BMI, change in lipid profile including a drop in LDL and an increase in HDL and a reduction in inflammatory markers IL-6 and CRP and the prothrombotic protein PAI-1 [20, 21]. Similar drops in weight and CRP levels were also described in a Mexican cohort of bariatric surgery patients [22]. The overall amelioration of obesity was further met by a reduction in medication needed.…”

Section: Discussionsupporting

confidence: 85%

Bariatric surgery in morbidly obese individuals affects plasma levels of protein C and thrombomodulin

Rega‐Kaun

Kaun

Ebenbauer

et al. 2018

J Thromb Thrombolysis

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Obesity is associated with a prothrombotic milieu and an increased risk for thrombotic events. Bariatric surgery is the most effective treatment for obesity resulting in dramatic weight loss and reduced inflammation and extrinsic coagulation pathway activation. Blood samples were drawn from 60 patients undergoing Roux-en-Y gastric bypass surgery before and 1 year after the intervention. Protein C (PC), activated PC (APC), soluble thrombomodulin (TM), soluble E-selectin (E-Sel), prothrombin time (PT) and activated partial thromboplastin time (aPTT) were evaluated. Both PC (187.4 ± 64.5% before surgery to 118.1 ± 48% 1 year after surgery, p < 0.001) and APC (138.7 ± 64.4% before surgery to 69.1 ± 65.7% after surgery, p < 0.001) were reduced following surgical intervention. TM showed a similar behavior with a reduction of soluble TM after the procedure from 5.7 ± 2.6 to 3.2 ± 1.4 ng/ml (p < 0.001). Similarly, soluble E-Sel was reduced after surgery from 26.6 ± 12.7 to 5.5 ± 4.1 ng/ml (p < 0.001). In contrast, aPTT was not shortened but slightly increased from 29.1 ± 4.8 s. before surgery to 31 ± 4.4 s. (p = 0.001) after surgery and levels of PT were reduced after surgery to 89.6 ± 15.5% from an initial 97.5 ± 13.5% (p < 0.001). In conclusion, we demonstrate a reduction of PC and APC 1 year after bariatric surgery accompanied by a reduction in soluble TM and soluble E-Sel. The reduction of PC and APC is not paralleled by a reduction but in contrast by a prolongation of aPTT suggesting a compensatory upregulation of PC during obesity. The reduction of TM and E-Sel might hint towards an improved endothelial function in this cohort of patients.

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Section: Discussionsupporting

confidence: 85%

Bariatric surgery in morbidly obese individuals affects plasma levels of protein C and thrombomodulin

Rega‐Kaun

Kaun

Ebenbauer

et al. 2018

J Thromb Thrombolysis

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“…Multiple studies have reported a decrease in CRP levels, a frequently assessed marker of systemic inflammation in the clinical setting after bariatric surgery. CRP has been shown to decrease from 1.15 to 0.34 mg/l at 6 months after either RYGB or LSG in a small cohort of Mexican subjects [63]. CRP was also found to fall from 0.68 to 0.55 mg/dl 3 months after LAGB, associated with a 13.9% weight loss, in 46 subjects [64].…”

Section: Bariatric Surgery Is Associated With a Decrease In Systemmentioning

confidence: 99%

Interplay between the Adaptive Immune System and Insulin Resistance in Weight Loss Induced by Bariatric Surgery

Villarreal-Calderón

Cuéllar

Ramos-González

et al. 2019

Oxidative Medicine and Cellular Longevity

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Low-grade chronic inflammation plays a pivotal role among other pathophysiological mechanisms involved in obesity. Innate and adaptive immune cells undergo systemic proinflammatory polarization that gives rise to an increased secretion of proinflammatory cytokines, which in turn leads to insulin resistance. Bariatric surgery is currently the most effective treatment for obesity, as it brings on significant weight loss, glucose metabolism improvement, and a decrease in systemic inflammation biomarkers. After bariatric surgery, several changes have been reported to occur in adaptive immunity, including reduction in CD4+ and CD8+ T cell counts, a decrease in the Th1/Th2 ratio, an increase in B regulatory cells, and reduction in proinflammatory cytokine secretion. Overall, there seems to be a major shift in several lymphocyte populations from a proinflammatory to an anti-inflammatory phenotype. Furthermore, increased antioxidant activity and reduced lipid and DNA oxidation products have been reported after bariatric surgery in circulating mononuclear cells. This paper highlights the shift in the adaptive immune system in response to weight loss and improved insulin sensitivity, as well as the interplay between immunological and metabolic adaptations as a result of bariatric surgery. Finally, based on data from research, we propose several mechanisms such as changes in adaptive immune cell phenotypes and their by-products, recruitment in adipose tissue, reduced oxidative stress, and modification in metabolic substrate availability as drivers to reduce low-grade chronic inflammation after bariatric surgery in severe obesity.

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“…C‐reactive protein (CRP), an important inflammatory marker in serum, has been reported to be elevated in persons who are obese, and correlates with insulin resistance and endothelial dysfunction. 2 Obesity or an increase of fatty tissue causes chronic inflammation in the body, which in turn causes an increase in cytokine synthesis. 3 The level of CRP in blood at an acute stage is an early marker of inflammation or infection, and has been associated with central obesity.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, they suffer from a low‐grade chronic proinflammatory state, which is the factor that links endothelial dysfunction to insulin resistance and obesity. C‐reactive protein (CRP), an important inflammatory marker in serum, has been reported to be elevated in persons who are obese, and correlates with insulin resistance and endothelial dysfunction 2 . Obesity or an increase of fatty tissue causes chronic inflammation in the body, which in turn causes an increase in cytokine synthesis 3 .…”

Section: Introductionmentioning

confidence: 99%

Retro walking treadmill training reduces C—reactive protein levels in overweight and obese young adults: A randomized comparative study

Soman

Chandy

Alkhathami

et al. 2023

Health Science Reports

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Background and Aims Retro walking has been shown to acquire a greater metabolic cost, placing a higher cardiopulmonary demand on the body, when compared with forward walking at a similar speed. The aim of this study was to compare the effect of retro walking with that of forward walking on C‐reactive protein (CRP) levels, body mass index (BMI) and blood pressure (BP) and to understand the influence of independent factors namely systolic blood pressure (SBP), diastolic blood pressure (DBP) and BMI on CRP in untrained overweight and obese young adults. Methods This was a randomised controlled trial whereby 106 participants underwent either retro walking ( n = 53) or forward walking ( n = 53) treadmill training four times a week for 12 weeks before and after which CRP, BMI, and BP levels were measured. Comparison of the measured values before and after intervention and between the groups was done and influence of BMI and BP on CRP levels was determined. Results Both groups recorded a significant decrease ( p < 0.001) in CRP, BMI, and BP levels postintervention. The participants who underwent retro walking training showed a significantly ( p < 0.001) higher decrease in all the outcomes as compared with the forward walking group. C‐reactive protein levels were seen to be influenced by BMI and DBP. Conclusion Retro‐walking training leads to greater decrease in CRP, BMI, and BP when compared with forward walking, and CRP levels are influenced by BMI and DBP. Retro walking treadmill training can be used preferentially to bring about reduction in cardiovascular risk factors.

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Nivel de proteína C reactiva en pacientes con obesidad mórbida antes y después de cirugía bariátrica

Abstract: Preoperative CRP had a significant lineal relation to weight and body mass index. Patients who underwent bariatric surgery had a significant decrease in CRP, weight, and fasting glucose at 6 months after surgery.

Cited by 11 publications

References 20 publications

Bariatric surgery in morbidly obese individuals affects plasma levels of protein C and thrombomodulin

Bariatric surgery in morbidly obese individuals affects plasma levels of protein C and thrombomodulin

Interplay between the Adaptive Immune System and Insulin Resistance in Weight Loss Induced by Bariatric Surgery

Retro walking treadmill training reduces C—reactive protein levels in overweight and obese young adults: A randomized comparative study

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