Excess mortality in mothers of patients with polycystic ovary syndrome

Louwers, Yvonne V.; Roest-Schalken, M. E.; Kleefstra, Nanne; Lennep, Jeanine Roeters van; Berg, M. van den; Fauser, Bart C.J.M.; Bilo, Henk J. G.; Sijbrands, Eric J.G.; Laven, Joop S.E.

doi:10.1093/humrep/deu107

Cited by 7 publications

(3 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…But this was not the case for the mothers of PCOS patients. In contrast, a recent study by Louwers et al (22) in 946 mothers and 902 fathers of PCOS patients noted a statistically significant excess mortality (standardized mortality ratio 1.5; 95% CI, 1.15-1.92) in mothers R60 years old compared with the general Dutch population. Mothers with diabetes had a two times mortality risk compared with control women with diabetes (relative risk 2; 95% CI, 1.19-3.41).…”

Section: Discussionmentioning

confidence: 72%

Cardiovascular disease risk in first-degree relatives of women with polycystic ovary syndrome

Vipin

Dabadghao

Shukla

et al. 2016

Fertility and Sterility

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 72%

Cardiovascular disease risk in first-degree relatives of women with polycystic ovary syndrome

Vipin

Dabadghao

Shukla

et al. 2016

Fertility and Sterility

View full text Add to dashboard Cite

show abstract

“…We have reported that the prevalence of the metabolic syndrome, dyslipidemia, and hypertension were increased in FDRs of women with PCOS compared with control women (88). In addition, excess mortality was found in the diabetic mothers of patients with PCOS compared with diabetic women from the general population (89). In addition, a heritable component of b-cell dysfunction has been found in the families of women with PCOS (39).…”

Section: Discussionmentioning

confidence: 95%

Diabetes mellitus and insulin resistance in mothers, fathers, sisters, and brothers of women with polycystic ovary syndrome: a systematic review and meta-analysis

Yılmaz

Vellanki

Ata

et al. 2018

Fertility and Sterility

View full text Add to dashboard Cite

show abstract

“…These studies, however, did not find a significant relationship between PCOS women and a family history of diabetes. On the contrary, Louwers et al [ 46 ] evidenced that mothers (but not fathers) above age 60 years of patients with PCOS display increased all-cause mortality, most likely as result of type 2 diabetes mellitus.…”

Section: Genetic and Clinical Associations Of Female Infertility Etiomentioning

confidence: 99%

Infertility etiologies are genetically and clinically linked with other diseases in single meta-diseases

Tarı́n

Garcı́a-Pérez

Hamatani

et al. 2015

Reprod Biol Endocrinol

View full text Add to dashboard Cite

The present review aims to ascertain whether different infertility etiologies share particular genes and/or molecular pathways with other pathologies and are associated with distinct and particular risks of later-life morbidity and mortality. In order to reach this aim, we use two different sources of information: (1) a public web server named DiseaseConnect (http://disease-connect.org) focused on the analysis of common genes and molecular mechanisms shared by diseases by integrating comprehensive omics and literature data; and (2) a literature search directed to find clinical comorbid relationships of infertility etiologies with only those diseases appearing after infertility is manifested. This literature search is performed because DiseaseConnect web server does not discriminate between pathologies emerging before, concomitantly or after infertility is manifested. Data show that different infertility etiologies not only share particular genes and/or molecular pathways with other pathologies but they have distinct clinical relationships with other diseases appearing after infertility is manifested. In particular, (1) testicular and high-grade prostate cancer in male infertility; (2) non-fatal stroke and endometrial cancer, and likely non-fatal coronary heart disease and ovarian cancer in polycystic ovary syndrome; (3) osteoporosis, psychosexual dysfunction, mood disorders and dementia in premature ovarian failure; (4) breast and ovarian cancer in carriers of BRCA1/2 mutations in diminished ovarian reserve; (5) clear cell and endometrioid histologic subtypes of invasive ovarian cancer, and likely low-grade serous invasive ovarian cancer, melanoma and non-Hodgkin lymphoma in endometriosis; and (6) endometrial and ovarian cancer in idiopathic infertility. The present data endorse the principle that the occurrence of a disease (in our case infertility) is non-random in the population and suggest that different infertility etiologies are genetically and clinically linked with other diseases in single meta-diseases. This finding opens new insights for clinicians and reproductive biologists to treat infertility problems using a phenomic approach instead of considering infertility as an isolated and exclusive disease of the reproductive system/hypothalamic–pituitary–gonadal axis. In agreement with a previous validation analysis of the utility of DiseaseConnect web server, the present study does not show a univocal correspondence between common gene expression and clinical comorbid relationship. Further work is needed to untangle the potential genetic, epigenetic and phenotypic relationships that may be present among different infertility etiologies, morbid conditions and physical/cognitive traits.

show abstract

Excess mortality in mothers of patients with polycystic ovary syndrome

Cited by 7 publications

References 36 publications

Cardiovascular disease risk in first-degree relatives of women with polycystic ovary syndrome

Cardiovascular disease risk in first-degree relatives of women with polycystic ovary syndrome

Diabetes mellitus and insulin resistance in mothers, fathers, sisters, and brothers of women with polycystic ovary syndrome: a systematic review and meta-analysis

Infertility etiologies are genetically and clinically linked with other diseases in single meta-diseases

Contact Info

Product

Resources

About