The efficacy of three formulations of Lippia sidoides Cham. essential oil in the reduction of salivary Streptococcus mutans in children with caries: A randomized, double-blind, controlled study

Lobo, Patrícia Leal Dantas; Fonteles, Cristiane Sá Roriz; Valadas, Lídia Audrey Rocha; Jamacaru, Francisco Vagnaldo Fechine; Fonseca, Said Gonçalves da Cruz; Carvalho, Cibele Barreto Mano de; Moraes, Maria Elisabete Amaral de

doi:10.1016/j.phymed.2014.04.021

Cited by 48 publications

(57 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nesse estudo mesmo em menores concentrações o carvacrol apresentou atividade antimicrobiana superior ao timol. Estudos demonstram que quando associados, existe um sinergismo entre os dois compostos, aumentando assim a atividade antimicrobiana (BARROSO, 2010;LOBO et al, 2014;DIDRY et al,1993).…”

Section: Discussionunclassified

“…Em um estudo longitudinal, compararamse vernizes dentários de carvacrol a 20%, timol a 20% e carvacrol a 10% + timol a 10% na oclusal de molares de 90 crianças livres de cárie, que de acordo com a American Academic of Pediatric Dentistry se enquadravam nos critérios de alto risco de ter a doença. Após achados microbiológicos salivares, o verniz com os dois constituintes demonstrou uma maior atividade antimicrobiana, sendo assim considerado uma alternativa para a prevenção da cárie precoce de infância (BARROSO, 2010;LOBO et al, 2014).…”

Section: Discussionunclassified

“…Diversas são as formulações medicamentosas de origem natural descritas para uso odontológico, onde destacam-se cimento endodôntico, vernizes dentários, dentifrícios e formulações de gel e bochecho de diversas plantas (LOBO et al, 2014;BARROSO, 2010;VASCONCELOS et al, 2008;BOTELHO et al, 2007b;BOTELHO et al, 2008 (LOBO et al, 2011).…”

Section: Uso De Plantas Medicinais Em Odontologiaunclassified

See 2 more Smart Citations

Atividade Farmacológica do Óleo Essencial de Lippia sidoides em Odontologia: Uma Revisão de Literatura

et al. 2015

Self Cite

View full text Add to dashboard Cite

RESUMO:Durante um longo período, plantas têm sido avaliadas como fonte de produtos naturais para preservar a saúde humana, inclusive para prevenção de doenças orais, especialmente cárie e doença periodontal. A cárie e a doença periodontal estão associadas a patógenos orais. A atividade antimicrobiana de várias plantas tem sido avaliada contra estes microrganismos patogênicos, dentre elas a Lippia sidoides Cham, uma planta popularmente conhecida como alecrim-pimenta, comumente encontrada no Nordeste do Brasil. Este artigo apresenta uma revisão das diversas atividades biológicas da Lippia sidoides Cham, destacando o seu potencial farmacológico no tratamento e/ou cura de várias doenças como a cárie e a doença periodontal possibilitando, assim, o desenvolvimento de formulações farmacêuticas seguras e eficazes a partir desta fonte natural. PALAVRAS-CHAVE:Cárie Dentária; Doença Periodontal; Lippia sidoides. PHARMACOLOGICAL ACTIVIT Y OF ESSENTIAL OIL OF Lippia sidoides IN DENTISTRY: A REVIEW OF THE LITERATUREABSTRACT: For many years plants have been considered as the source of natural products for the preservation of human health, including the prevention of oral diseases, especially caries and periodontal diseases. Since caries and periodontal diseases are associated with oral pathogens, antimicrobial activity of several plants have been evaluated against pathogenic microorganisms, especially Lippia sidoides Cham, popularly known in Brazil as 'alecrim-pimenta', found in the northeastern region of Brazil. Current analysis comprises a review of the different biological activities of Lippia sidoides Cham, with special reference to its pharmacological properties in the treatment and cure of several diseases, such as caries and periodontal diseases. The above may develop into safe and efficacious pharmaceutical formulations from a natural source.

show abstract

Section: Discussionunclassified

Section: Uso De Plantas Medicinais Em Odontologiaunclassified

See 1 more Smart Citation

Atividade Farmacológica do Óleo Essencial de Lippia sidoides em Odontologia: Uma Revisão de Literatura

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…It is also important to highlight that with 1% essential oil of P. heptaphyllum, the components of the oil will be diluted in a concentration similar to a commercial mouthwash such as listerine (menthol 0.042%, thymol 0.064%, methyl salicylate 0.06% and eucalyptol 0.092%) (Pan et al, 2010;Oyanagi et al, 2012). There are some studies about essential oils mouthwash, several using a 0.2 to 1.4% concentration of essential oil (Kothiwale et al, 2014;Lobo et al, 2014;Quintas et al, 2014) and others in which the final concentration is omitted (Batista et al, 2014). An antiseptic agent to be used in children should not be harmful to the mucosa; its toxicity should be low if ingested accidentally, and it should be free from sugar and alcohol (Subramanian and Nandan, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Chlorhexidine is known as the most effective commercial solution and is used as the gold standard in controlling plaque, because it is effective on gram-negative and gram-positive yeast (Nelson-Filho et al, 2011;Subramanian and Nandan, 2011;Juiz et al, 2010;Nelson-Filho et al, 2000). There are several studies which compare either the effectiveness or effect of chlorhexidine-containing mouthrinses and different products on dental plaque, gingivitis and caries prophylaxis, using a one-week period of washout (Charangundla et al, 2014;Lobo et al, 2014;Venu et al, 2013;Barnes et al, 2011;Franco Neto et al, 2008). The studies showed that chlorhexidine significantly reduced the mutans streptococci group or other microorganisms' levels, but these levels returned to baseline (Lobo et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Stability and disinfecting proprieties of the toothbrush rinse of the essential oil of Protium heptaphyllum

Fernanda¹,

Otavio²,

Mirian³

et al. 2015

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

Protium heptaphyllum (PH) is rich in essential oil, has anti-inflammatory properties and has no toxic potential. However, data is unavailable about its antiseptic effect against bacteria that cause caries. This study aimed to evaluate the antiseptic effect of the toothbrush rinse of essential oil of PH as well as its chemical stability. The toothbrush rinse was prepared with 1% essential oil of PH. The minimum inhibitory concentration (MIC) of the essential oil and toothbrush rinse were evaluated against Streptococcus mutans (ATCC 25175™). The ex vivo study was double-blinded and randomised; the children were divided into three groups, each participating in a crossover design where all solutions (water, toothbrush rinse (1%) and chlorhexidine (0.12%) were used in all stages by different groups of children. The chemical composition of the essential oil and toothbrush rinse were analysed by gas chromatography coupled to mass spectrometry. The stability was evaluated at three time points. The essential oil and toothbrush rinse exhibited antimicrobial activity against S. mutans, MIC = 0.125 and 2.4 µg/ml. The toothbrush rinse showed the same effect as chlorhexidine on disinfecting the toothbrushes contaminated with mutans streptococci (pH = 57.3 ± 5.3%; chlorhexidine 55.5 ± 13.3%; water 39.4 ± 5.8%; p > 0.05). Chromatographic analysis showed that the essential oil contained monoterpenes as a major component, and the toothbrush rinse possessed the same constituents as the pure essential oil, except for α-terpineol. Storage did not cause chemical degradation of the toothbrush rinse, but decreased the concentration of the chemical constituents. The toothbrush rinse of essential oil of P. heptaphyllum showed antiseptic properties and exhibited antimicrobial activity against mutans streptococci.

show abstract

Green synthesis of silver nanoparticles and evaluation of their effects on the Porphyromonas gingivalis bacterial biofilm formation

Hedayatipanah,

Gholami,

Farmany

et al. 2024

Clinical & Exp Dental Res

View full text Add to dashboard Cite

ObjectiveThis study aimed to evaluate the impact of silver nanoparticles (AgNPs) synthesized from propolis on the formation of Porphyromonas gingivalis biofilms.Material and MethodsAgNPs were synthesized from propolis, and their inhibitory effect on P. gingivalis biofilm formation was assessed. Different concentrations of AgNPs (0.1%, 0.3%, and 0.5%) were tested to determine the dose‐dependent antibacterial activity.ResultsThe results of this study indicated that AgNPs exhibited an inhibitory effect on P. gingivalis biofilm formation. The antibacterial activity of AgNPs was dose‐dependent, with concentrations of 0.1%, 0.3%, and 0.5% showing effectiveness. Notably, the concentration of 0.5% demonstrated the most significant anti‐biofilm formation activity.ConclusionThe results of this study suggest that AgNPs synthesized from propolis have potential as an effective option for enhancing periodontal treatment outcomes. The inhibitory effect of AgNPs on P. gingivalis biofilm formation highlights their potential as alternative antimicrobial agents in the management of periodontal diseases.

show abstract

The efficacy of three formulations of Lippia sidoides Cham. essential oil in the reduction of salivary Streptococcus mutans in children with caries: A randomized, double-blind, controlled study

Cited by 48 publications

References 16 publications

Atividade Farmacológica do Óleo Essencial de Lippia sidoides em Odontologia: Uma Revisão de Literatura

Atividade Farmacológica do Óleo Essencial de Lippia sidoides em Odontologia: Uma Revisão de Literatura

Stability and disinfecting proprieties of the toothbrush rinse of the essential oil of Protium heptaphyllum

Green synthesis of silver nanoparticles and evaluation of their effects on the Porphyromonas gingivalis bacterial biofilm formation

Contact Info

Product

Resources

About