Determinantes sociales adversos y riesgo para anomalías congénitas seleccionadas

Pawluk, Mariela Soledad; Campaña, Hebe; Gili, Juan Antonio; Comas, Belén; Giménez, Lucas Gabriel; Villalba, María Inés; Scala, Sandra C.; Poletta, Fernando A.; Camelo, Jorge Santiago López

doi:10.5546/aap.2014.215

Cited by 7 publications

(1 citation statement)

References 33 publications

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“…La etiología del LPH es multifactorial ya que está influida por factores genéticos, teratógenos y ambientales (10)(11), sin embargo, no existen estudios concluyentes que ayuden a determinar con exactitud las causas que la provocan, de manera que no se cuenta con medios predictivos eficaces que permitan su prevención (12). Aunque su etiología real es incierta, en la literatura se reportan factores de riesgo asociados como: consumo de contaminantes en alimentos (pesticidas), alcohol, tabaco, desnutrición y plomo en mujeres expuestas antes del embarazo o en las primeras semanas de la gestación (13,14). Los indicadores demuestran que en el 25 % de los casos se conoce la causa, de los cuales el 75 % de los casos es multifactorial y en el 20 % al 25 % existe algún antecedente familiar (15).…”

Section: Revista Nacional De Odontologíaunclassified

Anomalías dentales de los pacientes con labio y paladar hendido

Peña

Aricapa

2019

Rev. nac. odontol.

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Introducción: el labio o paladar hendido es la malformación cráneo facial más prevalente, su etiología es multifactorial y produce diferentes anomalías dentales, entre las más frecuentes están: de número, forma, posición, tamaño, estructura y aumenta la probabilidad de desarrollar caries dental. Estas producen a los pacientes problemas de deglución, habla y fonación, por esto su abordaje es multidisciplinario para tratar la variabilidad de implicaciones estéticas, funcionales, anatómicas y psicológicas.Materiales y métodos: se realizó una revisión descriptiva de la literatura incluyendo artículos originales, meta análisis y revisiones bibliográficas, publicados entre el 2012 y 2018 que abordaran anomalías dentales de pacientes con LPH no sindrómico, excluyendo reportes de caso, tesis de pregrado y posgrado. Resultados: dentro de las anomalías dentales más frecuentes se encontraron: anomalías de forma (diente cónico y fusión dental), alteraciones de número (agenesias dentales, dientes supernumerarios), anomalías de posición (mesioversión, distoversión, giroversión y gresiones), de tamaño (microdoncia y macrodoncia), de estructura (amilogénesis imperfecta) y alta prevalencia de caries dental.

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Section: Revista Nacional De Odontologíaunclassified

Anomalías dentales de los pacientes con labio y paladar hendido

Peña

Aricapa

2019

Rev. nac. odontol.

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Geographic clusters of congenital anomalies in Argentina

Groisman¹,

Gili

Giménez

et al. 2016

J Community Genet

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Geographical clusters are defined as the occurrence of an unusual number of cases higher than expected in a given geographical area in a certain period of time. The aim of this study was to identify potential geographical clusters of specific selected congenital anomalies (CA) in Argentina. The cases were ascertained from 703,325 births, examined in 133 maternity hospitals in the 24 provinces of Argentina. We used the spatial scan statistic to determine areas of Argentina which had statistically significant elevations of prevalence. Prenatal diagnosis followed by referral of high-risk pregnancies to high complexity hospitals in a hospital-based surveillance system can create artifactual clusters. We assessed the referral bias by evaluating the prevalence heterogeneity within each cluster. Eight clusters of selected CAs with unusually high birth prevalence were identified: anencephaly, encephalocele, spina bifida, diaphragmatic hernia, talipes equinovarus, omphalocele, Cleft lip with or without cleft palate (CL/P), and Down syndrome. The clusters of Down syndrome and CL/P observed in this study match the previously reported clusters. These findings support local targeted interventions to lower the prevalence of the CAs and/or further research on the cause of each cluster. The clusters of spina bifida, anencephaly, encephalocele, omphalocele, congenital diaphragmatic hernia, and talipes equinovarus may be influenced by prenatal diagnosis and referral to high complexity hospitals.

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Another piece of the Zika puzzle: assessing the associated factors to microcephaly in a systematic review and meta-analysis

et al. 2020

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Background: Although it is known that Zika virus (ZIKV) infection during pregnancy may lead to microcephaly in the fetus, the prognostic factors associated with this tragic disorder remain unclear. We conducted a systematic review and meta-analysis to assess the prognostic factors associated with the incidence of microcephaly in congenital ZIKV infection. Methods: We conducted a comprehensive search in Ovid MEDLINE, Ovid MEDLINE (R) Epub ahead of print, Embase, Embase Classic, Web of Science, CINAHL, Cochrane CENTRAL, LILACS, and various thesis databases to identify human studies reporting microcephaly associated with congenital ZIKV infection. We requested primary data from the authors of the included studies to calculate summary estimates and conduct the meta-analysis of the most prevalent factors. Results: We screened 4106 titles and abstracts, and identified 12 studies for inclusion in the systematic review. The assessment of ZIKV infection and the definition of microcephaly varied among studies. A total of 6154 newborns/ fetuses were enrolled; of those, 1120 (18.20%) had a diagnostic of ZIKV infection, of which 509 (45.45%) were diagnosed with microcephaly. Nine studies addressed the link between congenital ZIKV infection and neurological findings in newborns/fetuses. Half of the studies provided primary data. Three out of 11 factors of interest seem to be prognostic factors of microcephaly: infant's sexmales compared to females: Relative Risk (RR) 1.30, 95% Confidence Interval (95% CI) 1.14 to 1.49; the stage of pregnancy when infection occurredinfection in the first trimester of pregnancy compared to infection at other stages of pregnancy: RR 1.41, 95% CI 1.09 to 1.82; and asymptomatic infection compared to symptomatic infection during pregnancy: RR 0.68; 95% CI 0.60 to 0.77. Conclusion: Our findings support the female-biased resistance hypothesis and reinforce the risk associated with the stage of pregnancy when ZIKV infection occurs. Continued surveillance of ZIKV infection during pregnancy is needed to identify additional factors that could contribute to developing microcephaly in affected fetuses.

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Determinantes sociales adversos y riesgo para anomalías congénitas seleccionadas

Cited by 7 publications

References 33 publications

Anomalías dentales de los pacientes con labio y paladar hendido

Anomalías dentales de los pacientes con labio y paladar hendido

Geographic clusters of congenital anomalies in Argentina

Another piece of the Zika puzzle: assessing the associated factors to microcephaly in a systematic review and meta-analysis

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