Regional lymphomatoid papulosis in association with pseudoepitheliomatous hyperplasia: 13 years follow‐up

Abstract

mucosal lesions, 5,6 the handheld device seems to improve the access to difficult areas.In conclusion, our two cases support the possible application and usefulness of RCM for confirmation of inflammatory mucosal diseases, excluding tumoural processes and orienting the biopsy site selection. More advanced experiences on different oral mucosa diseases, also involving deeper areas of the oral cavity, are needed to demonstrate the effective usefulness of the handheld RCM in oral diseases diagnosis and patient management. References 1 Longo C, Zalaudek I, Argenziano G, Pellacani G. New directions in dermatopathology. in vivo confocal microscopy in clinical practice. Dermatol Clin 2012; 30: 799-814. 2 Contaldo M, Agozzino M, Moscarella E, Esposito S, Serpico R, Ardig o M. In vivo characterization of healthy oral mucosa by reflectance confocal microscopy: a translational research for optical biopsy. Ultrastruct Pathol 2013; 37: 151-158. 3 Alessi SS, Nico MM, Fernandes JD, Lourenc ßo SV. Reflectance confocal microscopy as a new tool in the in vivo evaluation of desquamative gingivitis: patterns in mucous membrane pemphigoid, pemphigus vulgaris and oral lichen planus. Br J Dermatol 2013; 168: 257-264. 4 Agozzino M, Bhasne P, Franceschini C, Vincenza G, Catrical a C, Ardig o M. Non-invasive, in vivo assessment of oral squamous cell carcinoma. Br J Dermatol 2014; 170: 754-756. 5 Cinotti E, Perrot JL, Labeille B, Adegbidi H, Cambazard F. Reflectance Confocal Microscopy for the diagnosis of vulvar melanoma and melanosis. Dermatol Surg 2012; 38: 1962-1967. 6 Ferrari A, Agozzino M, Ardig o M et al. Dermoscopic and Confocal Microscopy patterns of vulvar mucosal melanotic macules.

Two Histologic Patterns of Lymphomatoid Papulosis Occurring in a Child: A Matter of Timing?

“…Nevertheless, careful histologic examination revealed no keratinocyte atypia. Pseudoepitheliomatous hyperplasia in lesions of LyP have been reported in adults in small case series, but rarely in pediatric patients 16,17. Its occurrence, however, has no significant difference in clinical outcome or prognosis.…”

“…Pseudoepitheliomatous hyperplasia in lesions of LyP have been reported in adults in small case series, but rarely in pediatric patients. 16,17 Its occurrence, however, has no significant difference in clinical outcome or prognosis. Keratoacanthomas have also been reported to occur in older patients with LyP and has not been reported in pediatric patients.…”

A case report of granulomatous lymphomatoid papulosis

“…Overlapping cases with more than one subtype in a single case have also been reported [14]. Less common variants such as folliculotropic (F subtype), [15,16], syringotropic, spindle cell, angioinvasive, pseudoepitheliomatous, intralymphatic, and granulomatous eccrinotropic [17][18][19][20][21][22] are not yet listed in the official WHO classification. Unfortunately, there is no established correlation between histopathologic subtypes and clinical presentation, apart from type E which includes eschar-like necrosis [2,23].…”