MicroRNAs in the skeleton: Cell-restricted or potent intercellular communicators?

Eerden, Bram C. J. van der

doi:10.1016/j.abb.2014.04.016

Cited by 27 publications

(22 citation statements)

References 97 publications

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“…In maintaining bone homeostasis, miRNAs regulate the differentiation of bone precursor cells into osteoclasts and function of mature osteoclasts in a cell-restricted and/or paracrine/endocrine manner (Gamez et al, 2014, van der Eerden, 2014). In a previous study, 9 miRNAs were clinically identified as being up-regulated in the serum of osteoporosis patients, and 6 miRNAs exhibited significantly higher expression in the bone tissue of osteoporotic patients (Seeliger et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Osteoporotic bone of miR-150-deficient mice: Possibly due to low serum OPG-mediated osteoclast activation

et al. 2015

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MicroRNA (miR)-150 has been shown to control B and T cell differentiation in the bone marrow. The regulation of B and T cells is directly or systematically associated with bone remodeling cells such as osteoclasts; however, the functional role of miR-150 in bone homeostasis has not been well studied. Here, we observed down-regulation of miR-150 during in vitro osteoclast differentiation and, furthermore, that miR-150 knockout mice exhibit decreased bone mass and an increased number of osteoclasts. miR-150 deficiency did not affect osteoclast differentiation, but miR150 knockout mice had significantly lower osteoprotegrin (OPG) serum levels, suggesting that the reduction of serum OPG level in miR-150 knockout mice might induce B cell expansion and subsequently increase serum levels of immunoglobulins for activating osteoclast differentiation.

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Section: Introductionmentioning

confidence: 99%

Osteoporotic bone of miR-150-deficient mice: Possibly due to low serum OPG-mediated osteoclast activation

et al. 2015

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“…Recently, some researchers reviewed the importance of miRNAs in post-transcriptional regulation of skeletal development. [16][17][18] The functions of miR-21, miR-155 and miR-223 in osteoclast differentiation have been summarized in previous reviews. 19,20 In this paper, we reviewed the role of all relevant miRNAs in osteoclasts and related bone diseases, such as osteoporosis ( Table 1).…”

Section: Introductionmentioning

confidence: 99%

The role of MicroRNAs in Osteoclasts and Osteoporosis

et al. 2014

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These authors contributed equally to this work. Keywords: MicroRNA, osteoclast, osteoporosisAbbreviations: GM-CSF, Granulocyte macrophage colony-stimulating factor; MiRNA, microRNA; 3'-UTR; 3' untranslated region; BMMs, bone marrow macrophages; PDCD4, programmed cell death 4; FasL, Fas ligand; PIO, particle-induced osteolysis; Calcr, calcitonin receptor; RDX, radixin; M-RIP, myosin phosphatase-Rho interacting protein; ITGA5, integrin a5; Fzd3, frizzled 3; ALP, alkaline phosphatase; TRAP, tartrate-resistant acid phosphatase; CXCL11, chemokine (C-X-C motif) ligand 11; CXCR3, chemokine (C-X-C motif) receptor 3; SLC39A1, solute carrier family (zinc transporter) member 1; TRAF6, TNF receptor-associated factor 6; OVX, ovariectomy; MAFB, V-maf musculoaponeurotic fibrosarcoma oncogene homolog B; CBL, Casitas B-lineage lymphoma proto-oncogene; PAG1, phosphoprotein associated with glycosphingolipid microdomains; TOB2, transducer of ERBB2; sICAM1, soluble intracellular adhesion molecule.Osteoclasts are the exclusive cells of bone resorption. Abnormally activating osteoclasts can lead to low bone mineral density, which will cause osteopenia, osteoporosis, and other bone disorders. To date, the mechanism of how osteoclast precursors differentiate into mature osteoclasts remains elusive. MicroRNAs (miRNAs) are novel regulatory factors that play an important role in numerous cellular processes, including cell differentiation and apoptosis, by post-transcriptional regulation of genes. Recently, a number of studies have revealed that miRNAs participate in bone homeostasis, including osteoclastic bone resorption, which sheds light on the mechanisms underlying osteoclast differentiation. In this review, we highlight the miRNAs involved in regulating osteoclast differentiation and bone resorption, and their roles in osteoporosis.

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“…These decreases in miR expression led to significant growth and skeletal defects, as a consequence of reductions in proliferation and differentiation of chondrocytes and osteoblasts [29]. Moreover, a variety of miRs have been shown to play a role in bone remodeling by regulating osteoblast and osteoclast differentiation, activity and survival [29,30]. Although the critical role of miRs in regulating bone development and homeostasis has been demonstrated by numerous studies, the mechanisms of their action and their roles in bone cell signaling still remain unclear.…”

Section: Microrna Biogenesis Structure and Functionmentioning

confidence: 99%

MicroRNAs and Connexins in Bone: Interaction and Mechanisms of Delivery

2017

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Purpose of review To describe the current knowledge on the cross-talk between connexins and microRNAs (miRs) in bone cells. Recent findings Connexins play a crucial role on bone development and maintenance, and disruptions in their abundance or localization can affect how bone perceives and responds to mechanical, hormonal, and pharmacological stimuli. Connexin expression can be modified by miRs, which modulate connexin mRNA and protein levels. Recently, different manners by which miRs and connexins can interact in bone have been identified, including mechanisms that mediate miR exchange between cells in direct contact through gap junctions, or between distant cells via extracellular vesicles (EVs). Summary We bring to light the relationship between miRs and connexins in bone tissue, with special focus on regulatory effects of miRs and connexins on gene expression, as well as the mechanisms that mediate miR exchange between cells in direct contact through gap junctions, or between distant cells via EVs.

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MicroRNAs in the skeleton: Cell-restricted or potent intercellular communicators?

Cited by 27 publications

References 97 publications

Osteoporotic bone of miR-150-deficient mice: Possibly due to low serum OPG-mediated osteoclast activation

Osteoporotic bone of miR-150-deficient mice: Possibly due to low serum OPG-mediated osteoclast activation

The role of MicroRNAs in Osteoclasts and Osteoporosis

MicroRNAs and Connexins in Bone: Interaction and Mechanisms of Delivery

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