Comparative studies on the genetic, antigenic and pathogenic characteristics of Bokeloh bat lyssavirus

Nolden, Tobias; Banyard, Ashley C.; Finke, Stefan; Fooks, Anthony R.; Hanke, Dennis; Höper, Dirk W.; Horton, Daniel L.; Mettenleiter, Thomas C.; Müller, Thomas; Teifke, Jens Peter; Freuling, Conrad Martin

doi:10.1099/vir.0.065953-0

Cited by 35 publications

(27 citation statements)

References 19 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Since 2010, two additional lyssaviruses have been detected in Europe. Bokeloh bat lyssavirus was detected in Germany in 2010 in a Natterer's bat (Myotis nattereri) and has subsequently been detected twice in M. nattereri in eastern France, and Germany, both in 2012 (Nolden et al 2014). Also in 2012, genetic evidence for another putative European lyssavirus, Lleida bat lyssavirus, was detected in brain tissue from a sick Miniopterus schreibersii in Spain (Arechiga Ceballos et al 2013).…”

Section: Bat Lyssavirus Infections By Dan Hortonmentioning

confidence: 99%

Recent Changes in Infectious Diseases in European Wildlife

Yon¹,

Duff

Ågren

et al. 2019

Journal of Wildlife Diseases

View full text Add to dashboard Cite

Many infectious diseases originating from, or carried by, wildlife affect wildlife conservation and biodiversity, livestock health, or human health. We provide an update on changes in the epidemiology of 25 selected infectious, wildlife-related diseases in Europe (from 2010-16) that had an impact, or may have a future impact, on the health of wildlife, livestock, and humans. These pathogens were selected based on their: 1) identification in recent Europe-wide projects as important surveillance targets, 2) inclusion in European Union legislation as pathogens requiring obligatory surveillance, 3) presence in recent literature on wildlife-related diseases in Europe since 2010, 4) inclusion in key pathogen lists released by the Office International des Epizooties, 5) identification in conference presentations and informal discussions on a group email list by a European network of wildlife disease scientists from the European Wildlife Disease Association, or 6) identification as pathogens with changes in their epidemiology during 2010-16. The wildlife pathogens or diseases included in this review are: avian influenza virus, seal influenza virus, lagoviruses, rabies virus, bat lyssaviruses, filoviruses, canine distemper virus, morbilliviruses in aquatic mammals, bluetongue virus, West Nile virus, hantaviruses, Schmallenberg virus, Crimean-Congo hemorrhagic fever (CCHF) virus, African swine fever virus, amphibian ranavirus, hepatitis E virus, bovine tuberculosis (Mycobacterium bovis), tularemia (Francisella tularensis), brucellosis (Brucella spp.), salmonellosis (Salmonella spp.), Coxiella burnetii, chytridiomycosis, Echinococcus multilocularis, Leishmania infantum, and chronic wasting disease. Further work is needed to identify all of the key drivers of disease change and emergence, as they appear to be influencing the incidence and spread of these pathogens in Europe. We present a summary of these recent changes during 2010-16 to discuss possible commonalities and drivers of disease change and to identify directions for future work on wildlife-related diseases in Europe. Many of the pathogens are entering Europe from other continents while others are expanding their ranges inside and beyond Europe. Surveillance for these wildlife-related diseases at a continental scale is therefore important for planet-wide assessment, awareness of, and preparedness for the risks they may pose to wildlife, domestic animal, and human health.

show abstract

Section: Bat Lyssavirus Infections By Dan Hortonmentioning

confidence: 99%

Recent Changes in Infectious Diseases in European Wildlife

Yon¹,

Duff

Ågren

et al. 2019

Journal of Wildlife Diseases

View full text Add to dashboard Cite

show abstract

“…The aetiological agent, the rabies virus (RABV), infects the central nervous system (CNS) of most mammals, including humans. It belongs to the family Rhabdoviridae (genus Lyssavirus, order Mononegavirales), and the genus Lyssavirus also includes rabies-related lyssaviruses such as Lagos bat virus (LBV), Mokola virus (MOKV) and Duvenhage virus (DUVV) Nolden et al, 2014). Human RABV infection is estimated to cause more than 55 000 deaths every year, mainly in Asia and Africa .…”

Section: Introductionmentioning

confidence: 99%

Contribution of the interaction between the rabies virus P protein and I-kappa B kinase ϵ to the inhibition of type I IFN induction signalling

Masatani

Ozawa

Yamada

et al. 2016

Journal of General Virology

View full text Add to dashboard Cite

The P protein of rabies virus (RABV) is known to interfere with the phosphorylation of the host IFN regulatory factor 3 (IRF-3) and to consequently inhibit type I IFN induction. Previous studies, however, have only tested P proteins from laboratory-adapted fixed virus strains, and to the best of our knowledge there is no report about the effect of P proteins from street RABV strains or other lyssaviruses on the IRF-3-mediated type I IFN induction system. In this study, we evaluated the inhibitory effect of P proteins from several RABV strains, including fixed and street virus strains and other lyssaviruses (Lagos bat, Mokola and Duvenhage viruses), on IRF-3 signalling. All P proteins tested inhibited retinoic acid-inducible gene-1 (RIG-I)-and TANK binding kinase 1 (TBK1)-mediated IRF-3-dependent IFN-b promoter activities. On the other hand, the P proteins from the RABV street strains 1088 and HCM-9, but not from fixed strains Nishigahara (Ni) and CVS-11 and other lyssaviruses tested, significantly inhibited I-kappa B kinase e (IKKe)-inducible IRF-3-dependent IFN-b promoter activity. Importantly, we revealed that the P proteins from the 1088 and HCM-9 strains, but not from the remaining viruses, interacted with IKKe. By using expression plasmids encoding chimeric P proteins from the 1088 strain and Ni strain, we found that the C-terminal region of the P protein is important for the interaction with IKKe. These findings suggest that the P protein of RABV street strains may contribute to efficient evasion of host innate immunity.

show abstract

“…In the Americas, rabies virus occurs in bats, and bat-derived rabies has become the leading cause of human rabies in the United States 6,7 . On every other continent where bats occur at least one distinct lyssavirus has been detected in bat populations, and the antigenic differences between some of the more divergent lyssaviruses from vaccine strains, mean there is the potential for reduced vaccine efficacy 8,9 against those strains. Understanding infection dynamics in the reservoir host is critical to understanding and managing the public and animal health risks, and yet fundamental questions remain concerning the dynamics and maintenance of lyssaviruses in bat host species.…”

mentioning

confidence: 99%

Between roost contact is essential for maintenance of European bat lyssavirus type-2 in Myotis daubentonii bat reservoir: ‘The Swarming Hypothesis’

Horton

Breed

Arnold

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

Many high-consequence human and animal pathogens persist in wildlife reservoirs. An understanding of the dynamics of these pathogens in their reservoir hosts is crucial to inform the risk of spill-over events, yet our understanding of these dynamics is frequently insufficient. Viral persistence in a wild bat population was investigated by combining empirical data and in-silico analyses to test hypotheses on mechanisms for viral persistence. A fatal zoonotic virus, European Bat lyssavirus type 2 (EBLV-2), in Daubenton's bats (Myotis daubentonii) was used as a model system. A total of 1839 M. daubentonii were sampled for evidence of virus exposure and excretion during a prospective nine year serial cross-sectional survey. Multivariable statistical models demonstrated age-related differences in seroprevalence, with significant variation in seropositivity over time and among roosts. An Approximate Bayesian Computation approach was used to model the infection dynamics incorporating the known host ecology. The results demonstrate that EBLV-2 is endemic in the study population, and suggest that mixing between roosts during seasonal swarming events is necessary to maintain EBLV-2 in the population. These findings contribute to understanding how bat viruses can persist despite low prevalence of infection, and why infection is constrained to certain bat species in multispecies roosts and ecosystems. Bats have been implicated as reservoirs for multiple viral, bacterial and protozoal pathogens of human and animal health importance, including Ebola virus, Bartonella spp., and rabies virus 1,2. Aspects of the ecology and demography of bats such as forming high-density aggregations, and flight permitting long-distance movement, may play a role in this ability to maintain a variety of pathogens 2. Mechanisms of pathogen persistence at the population level are often poorly understood, particularly when infection elicits a long lasting protective immune response 3. Rabies virus is one of a growing number of recognised lyssavirus species that are all capable of causing fatal encephalitis 4. The majority of these lyssaviruses are associated with bats 5. Although the full public and animal

show abstract

Comparative studies on the genetic, antigenic and pathogenic characteristics of Bokeloh bat lyssavirus

Cited by 35 publications

References 19 publications

Recent Changes in Infectious Diseases in European Wildlife

Recent Changes in Infectious Diseases in European Wildlife

Contribution of the interaction between the rabies virus P protein and I-kappa B kinase ϵ to the inhibition of type I IFN induction signalling

Between roost contact is essential for maintenance of European bat lyssavirus type-2 in Myotis daubentonii bat reservoir: ‘The Swarming Hypothesis’

Contact Info

Product

Resources

About