Topical Application of Chinese Herbal Medicine for Atopic Eczema: A Systematic Review with a Meta-Analysis

Gu, Sherman; Yang, Angela Wei Hong; Li, Chun Guang; Lu, Chuanjian; Xue, Charlie Changli

doi:10.1159/000360526

Cited by 18 publications

(9 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TCM may have some benefit for AD lesions, but the results are conflicting and reports on serious hepatotoxicity raise potential safety concerns. Well-designed, placebo-controlled clinical trials are warranted to evaluate the efficacy and safety of the use of TCM in adult AD [2,3,[39][40][41][42][43][44][45].…”

Section: Discussionmentioning

confidence: 99%

Is the alternative medicine a real alternative in adult atopic dermatitis? Experiences of 125 patients

Pónyai¹,

Temesvári²,

Kárpáti³

2016

Glob Dermatol

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Is the alternative medicine a real alternative in adult atopic dermatitis? Experiences of 125 patients

Pónyai¹,

Temesvári²,

Kárpáti³

2016

Glob Dermatol

View full text Add to dashboard Cite

show abstract

“…Any preparations incorporating or combined with an active pharmaceutical ingredient, other bioactive ingredients, vitamins or minerals were excluded. Topical Chinese herbal medicines were also excluded, as a recent systematic review dealing specifically with these was published in 2014 …”

Section: Methodsmentioning

confidence: 99%

“…Topical Chinese herbal medicines were also excluded, as a recent systematic review dealing specifically with these was published in 2014. 26 All patients had to be clinically diagnosed with AE. Studies on other types of eczema (e.g.…”

Section: Inclusion and Exclusion Criteriamentioning

confidence: 99%

Topical herbal medicines for atopic eczema: a systematic review of randomized controlled trials

et al. 2016

View full text Add to dashboard Cite

Despite the availability of medicines with proven efficacy, many patients use complementary or alternative medicines (CAMs) to manage atopic eczema (AE). Due to the lack of objective information on topical CAMs, this systematic review evaluates the current evidence for the efficacy and safety of topical herbal preparations in AE. Using Cochrane systematic review methodology, PubMed, the Cochrane Library, the Cochrane Central Register of Controlled Trials (CENTRAL), CINAHL (via EBSCO), MEDLINE (via EBSCO), Proquest Health and Medical Complete, GREAT and CAM-QUEST were searched from inception until June 2014. Bibliographies of retrieved studies were hand searched for further relevant trials. All controlled clinical trials of topical herbal medicines for AE in humans of any age were included regardless of the control intervention or randomization. Only English-language publications were considered. Eight studies met the inclusion criteria. Seven investigated extracts of single plants and one an extract from multiple plants. Only two studies that showed a positive effect were considered to have a low risk of bias across all domains (those of liquorice gel and Hypericum perforatum). In these two, the test product was reported to be superior to placebo. Despite variations in diagnostic criteria and lack of validated tools for outcome assessments in one of these, the promising results may warrant continued research in better-designed studies. No meta-analysis was performed due to heterogeneity in all studies. There is currently insufficient evidence of efficacy for any topical herbal extract in AE. Many studies had methodological flaws and even those showing efficacy were single trials with small patient cohorts.

show abstract

“…[105][106][107][108][109] Systematic reviews and metaanalyses have been performed which consistently demonstrated no conclusive evidence that most Chinese herbal concoctions could improve AD. [110][111][112][113][114] Generally, strength of evidence is low and the risks of bias are high in these studies. Mechanisms of action of herbal medicine have been reported.…”

Section: Miscellaneousmentioning

confidence: 99%

Experimental Drugs with the Potential to Treat Atopic Eczema

Hon¹,

Chan²,

Leung

2021

JEP

View full text Add to dashboard Cite

Introduction: Eczema or atopic dermatitis (AD) is a chronically relapsing dermatosis characterized by pruritus and a significant impact on the quality of life. Methods: The authors undertook a structured search of peer-reviewed research articles from PubMed and Google Scholar. Recent and up-to-date studies relevant to the topic were included. Results: This report overviews current treatment and experimental drug for AD. Topical agents including topical phosphodiesterase E4 (PDE4) inhibitors such as crisaborole are efficacious in the treatment of AD with few side effects. Monoclonal antibodies such as dupilumab given subcutaneously are efficacious for more severe disease. Systemic treatment can ameliorate symptoms in severe and recalcitrant AD. New systemic treatment includes several traditional herbal formulations that have undergone clinical trials using modern research methodology to determine their efficacy and safety. AD is associated with many complicating psychosocial issues. Often suboptimal efficacy is due to unrealistic expectations and poor compliance making treatment difficult in spite of effective treatment and efforts in drug discovery. Randomized trials have shown that novel topical and subcutaneous medications are safe and efficacious. Regarding herbs, a methodology for the investigation of herbal medications is often flawed and scientific evidence is lacking. Experimental drugs include various biologics, PDE4 and JAK inhibitors in topical, oral, subcutaneous or intravenous forms are in various phases of trials. Conclusion: Many novel medications demonstrate efficacy for AD. Experimental drugs include various biologics, PDE4 and JAK inhibitors are in various phases of trials.

show abstract

Topical Application of Chinese Herbal Medicine for Atopic Eczema: A Systematic Review with a Meta-Analysis

Cited by 18 publications

References 11 publications

Is the alternative medicine a real alternative in adult atopic dermatitis? Experiences of 125 patients

Is the alternative medicine a real alternative in adult atopic dermatitis? Experiences of 125 patients

Topical herbal medicines for atopic eczema: a systematic review of randomized controlled trials

Experimental Drugs with the Potential to Treat Atopic Eczema

Contact Info

Product

Resources

About