The genotype of the transporter associated with antigen processing gene affects susceptibility to colorectal cancer in Japanese

Yamauchi, Takenori; Takeuchi, Shigeru; Maehara, Naoki; Kuroda, Yoshiki

doi:10.1007/s12199-014-0388-4

Cited by 12 publications

(9 citation statements)

References 41 publications

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“…And polymorphisms in TAP genes [21][22][23][24][25] To date, several studies have reported the association between polymorphisms in TAP genes and human cancers. [26][27][28][29][30] For example, Ozbas-Gerceker et al found rs1057141 and rs2228396 to be associated with haematological malignancies, and Einstein et al detected an association between rs1057141 and rs1135216 and CC in an American population. 31 However, the association data of TAP polymorphisms with CC in Chinese population was rare, especially cervical intraepithelial neoplasia (CIN).…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms in transporter associated with antigen presenting are associated with cervical intraepithelial neoplasia and cervical cancer in a Chinese Han population

Yang

Liu

Zhang

et al. 2021

HLA

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The host immune system plays an important role in infectious diseases and cancers. The heterodimer formed by transporter associated with antigen presenting (TAP)1 and TAP2 is responsible for intracellular peptide loading onto MHC-I molecules. Studies have shown that single-nucleotide polymorphisms (SNPs) in TAP genes might affect the expression and function of TAP and be associated with cancer risk. We aimed to investigate the association of SNPs in the TAP1 and TAP2 genes with cervical intraepithelial neoplasia (CIN) and cervical cancer (CC) in a Chinese Han population. Six SNPs in the TAP1 gene and seven in the TAP2 gene were selected. The 13 SNPs were genotyped in 1255 healthy individuals, 575 patients with CIN and 1034 patients with CC using the SNaPshot assay. The association between these SNPs and CIN and CC risk was analysed. The allelic and genotypic distributions of rs41549617 and rs1135216 showed significant differences between the control and CC groups (P < 0.0038). The T allele of rs41549617 was associated with a decreased risk of CC (OR = 0.476, 95%CI: 0.286-0.791). Moreover, the G allele of rs1135216 appears to be associated with a decreased risk of CC (OR = 0.746; 95%CI: 0.632-0.881). The allele and genotype distribution of rs241441 showed a significant difference between the control and CC groups (P < 0.0038), and the rs241441 G allele was associated with an increased risk of CC (OR = 1.232, 95% CI: 1.092-1.398). In addition, the results of the association between TAP alleles and CC showed that TAP1*020101 and TAP1*0301 have an association with CC (P = 0.001 and P = 0.002, respectively). Our results demonstrate that the TAP1 and TAP2 genes are associated with CC in the Chinese Han population.

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Section: Introductionmentioning

confidence: 99%

Polymorphisms in transporter associated with antigen presenting are associated with cervical intraepithelial neoplasia and cervical cancer in a Chinese Han population

Yang

Liu

Zhang

et al. 2021

HLA

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“…1 Immune evasion, developed by tumor cells to survive attack by immune responses, is one of the plausible mechanisms underlying carcinogenesis. 2 The transporter associated with antigen processing (TAP) protein plays a critical role in the processing and presentation of intracellular antigens. 3 Cellular proteins including tumor associated gene products are degraded predominantly through the ubiquitin-proteasome pathway.…”

Section: Introductionmentioning

confidence: 99%

“…In 2012, a study reported that the annual number of cancer diagnoses will increase from 14 to 22 million by 2032 . Immune evasion, developed by tumor cells to survive attack by immune responses, is one of the plausible mechanisms underlying carcinogenesis …”

Section: Introductionmentioning

confidence: 99%

Quantitative assessment of the association between TAP2 rs241447 polymorphism and cancer risk

Liu

Chen

2019

J of Cellular Biochemistry

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The findings regarding the relation of transporter associated with antigen processing (TAP) to cancer risk have been inconsistent. The aim of this study was to comprehensively evaluate the association between TAP2 rs241447 polymorphism and cancer susceptibility. A meta‐analysis of nine investigations with 2800 cases and 1620 controls was conducted to gain a better understanding of the effect of TAP2 rs241447 polymorphism on cancer risk. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the strength of the correlation between TAP2 gene polymorphism and cancer susceptibility. The pooled results from TAP2 rs241447 polymorphism showed a decreased risk of cancer in two dominant genetic models (GG + AG vs AA: OR = 0.86, 95% CI, 0.75‐0.99; AG vs AA: OR = 0.85, 95% CI, 0.73‐0.99). From the subgroup analysis, decreased cancer susceptibility was found in Caucasians (GG + AG vs AA: OR = 0.82, 95% CI, 0.68‐0.99), especially among the subgroup of cervical carcinoma (GG + AG vs AA: OR = 0.82, 95% CI, 0.69‐0.96; AG vs AA: OR = 0.83, 95% CI, 0.70‐0.99). Overall, the results suggest that TAP2 rs241447 polymorphism contributes to decreased cancer susceptibility.

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“…Genomic DNA was extracted from peripheral blood lymphocytes using the conventional method [30]. Detection of single nucleotide polymorphisms (SNPs) of PER3 (rs2640908) was performed using the restriction fragment length polymorphism (PCR-RFLP) technique.…”

Section: Polymerase Chain Reaction (Pcr) Amplification and Genotypingmentioning

confidence: 99%

The correlation between PER3 rs2640908 polymorphism and colorectal Cancer in the Japanese population

et al. 2019

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Background: Colorectal cancer (CRC) is one of the most common cancers in Japan. Many factors influence this cancer, one of which is circadian rhythm disruption. Our research investigated the correlation between singlenucleotide polymorphisms (SNPs) in the Period 3 (PER3) (rs2640908), which is one of the circadian genes, and colorectal cancer in the Japanese population. Methods: The study participants consisted of 121 cases and 197 controls. DNA was extracted from participants' peripheral blood cells, and polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP) was performed to detect genotypes of PER3. Results: Participants with T/T genotype were at lower risk of developing colorectal cancer than participants with C/ C genotype (adjusted ORs = 0.32 (95% CI: 0.15-0.63)). When stratified by gender and smoking status, T/T genotype were associated with a decreased susceptibility to cancer in males only (adjusted ORs: 0.23 (95% CI: 0.09-0.59)), T/T genotype were also associated with a decreased susceptibility to cancer among both smokers and non-smokers. Conclusions: A significant association was found between the T allele of PER3 polymorphism and a reduced risk of colorectal cancer, especially in males. Smoking status showed no association with the relationship between PER3 genotype and CRC carcinogenesis.

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The genotype of the transporter associated with antigen processing gene affects susceptibility to colorectal cancer in Japanese

Abstract: The genotype of the TAP1 gene is associated with susceptibility to CRC.

Cited by 12 publications

References 41 publications

Polymorphisms in transporter associated with antigen presenting are associated with cervical intraepithelial neoplasia and cervical cancer in a Chinese Han population

Polymorphisms in transporter associated with antigen presenting are associated with cervical intraepithelial neoplasia and cervical cancer in a Chinese Han population

Quantitative assessment of the association between TAP2 rs241447 polymorphism and cancer risk

The correlation between PER3 rs2640908 polymorphism and colorectal Cancer in the Japanese population

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