Genome-Wide Association Study Identifies Variants in Casein Kinase II (
            <i>CSNK2A2</i>
            ) to be Associated With Leukocyte Telomere Length in a Punjabi Sikh Diabetic Cohort

Saxena, Richa; Bjonnes, Andrew; Prescott, Jennifer; Dib, Patrick; Natt, Praveen; Lane, Jacqueline M.; Lerner, Megan R.; Ye, Yuanqing; Li, Ka Wah; Maubaret, C.; Brackett, Daniel J.; Mirabello, Lisa; Kraft, Peter; Dinney, Colin P.; Stowell, Donald; Peyton, Marvin D.; Ralhan, Sarju; Wander, Gurpreet Singh; Mehra, N. K.; Salpea, Klelia D.; Gu, Jian; Wu, Xifeng; Mangino, Massimo; Hunter, David J.; Vivo, Immaculata De; Humphries, Steve E.; Samani, Nilesh J.; Spector, Tim D.; Savage, Sharon A.; Sanghera, Dharambir K.

doi:10.1161/circgenetics.113.000412

Cited by 50 publications

(48 citation statements)

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“…We carried out a two stage GWAS of 25(OH)D levels in a total of 3538 subjects comprised of 1387 individuals in a ‘discovery sample set’ and 2151 individuals in an independent ‘replication sample set’ from the AIDHS/SDS, described earlier [11,12]. All individuals in this study were recruited from the single geographical location of the state of Punjab, India.…”

Section: Methodsmentioning

confidence: 99%

Genome-wide association study of 25(OH) Vitamin D concentrations in Punjabi Sikhs: Results of the Asian Indian diabetic heart study

Sapkota

Hopkins

Bjonnes

et al. 2016

The Journal of Steroid Biochemistry and Molecular Biology

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Vitamin D deficiency is implicated in multiple disease conditions and accumulating evidence supports that the variation in serum vitamin D (25(OH)D) levels, including deficiency, is under strong genetic control. However, the underlying genetic mechanism associated with vitamin 25(OH)D concentrations is poorly understood. We earlier reported a very high prevalence of vitamin D deficiency associated with an increased risk for type 2 diabetes and obesity in a Punjabi Sikh diabetic cohort as part of the Asian Indian diabetic heart study (AIDHS). Here we have performed the first genome-wide association study (GWAS) of serum 25(OH)D on 3538 individuals from this Punjabi Sikh population. Our discovery GWAS comprised of 1387 subjects followed by validation of 24 putative SNPs (P <10−4) using an independent replication sample (n = 2151) from the same population by direct genotyping. A novel locus at chromosome 20p11.21 represented by rs2207173 with minor allele frequency (MAF) 0.29, [β = −0.13, p = 4.47 × 10−9] between FOXA2 and SSTR4 was identified to be associated with 25(OH)D levels. Another suggestive association signal at rs11586313 (MAF 0.54) [β = 0.90; p = 1.36 × 10−6] was found within the regulatory region of the IVL gene on chromosome 1q21.3. Additionally, our study replicated 3 of 5 known GWAS genes associated with 25(OH)D concentrations including GC (p = 0.007) and CYP2R1 (p = 0.019) reported in Europeans and the DAB1 (p = 0.003), reported in Hispanics. Identification of novel association signals in biologically plausible regions with 25(OH)D metabolism will provide new molecular insights on genetic drivers of vitamin D status and its implications in health disparities.

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Section: Methodsmentioning

confidence: 99%

Genome-wide association study of 25(OH) Vitamin D concentrations in Punjabi Sikhs: Results of the Asian Indian diabetic heart study

Sapkota

Hopkins

Bjonnes

et al. 2016

The Journal of Steroid Biochemistry and Molecular Biology

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“…17,18 However, other genome-wide association studies have identified single-nucleotide polymorphisms associated with TL, which do not contain candidate genes of telomere biology, but rather genes related to several cancers and other diseases. 19,20 Recently, Saxena et al 21 showed that variants in casein kinase II (CSNK2A2) are associated with leukocyte TL in a Punjabi Sikh Diabetic Cohort.…”

Section: Circ Cardiovasc Genetmentioning

confidence: 99%

Pro12Ala Polymorphism of the PPARγ2 Gene Interacts With a Mediterranean Diet to Prevent Telomere Shortening in the PREDIMED-NAVARRA Randomized Trial

García-Calzón

Martínez‐González

Razquín

et al. 2015

Circ Cardiovasc Genet

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Background— The gene variant Pro/Ala (rs1801282) in the PPARγ2 has been associated with lower cardiovascular risk and greater benefit from lifestyle interventions. This polymorphism also seems to be associated with longer lifespan, but no information on telomere length (TL) is available. Our aim was to study the association between the Ala allele and changes in TL in high cardiovascular risk subjects and the potential interaction with a Mediterranean dietary pattern. Methods and Results— A total of 521 subjects (55–80 years) participating in the Prevención con Dieta Mediterránea randomized trial were genotyped. Changes in TL, measured by quantitative real-time polymerase chain reaction (PCR), were assessed over 5 years of a nutritional intervention, which promoted adherence to the Mediterranean diet (MeDiet). Interestingly, Ala carriers showed lower telomere shortening after 5 years compared with the Pro/Pro genotype ( P =0.031). This association was modulated by MeDiet because those Ala carriers who reported better conformity to the MeDiet exhibited increased TL ( P <0.001). Moreover, a reduction in carbohydrate intake (≤9.5 g/d) resulted in increased TL among Ala carriers. Notably, an apparent gene–diet interaction was found through the observed changes in the MUFA+PUFA/carbohydrates ratio: as this ratio increased, TL lengthening was detected to a greater extent in the Ala carriers compared with the Pro/Pro subjects ( P for interaction <0.001). Conclusions— The Pro12Ala polymorphism is associated with TL homeostasis after 5 years follow-up in subjects at high cardiovascular risk. In addition, a higher adherence to the MeDiet pattern strengthens the prevention of telomere shortening among Ala carriers. Clinical Trial Registration— www.controlled-trials.com ; Unique Identifier: ISRCTN35739639.

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“…23 rs1046623910:43849827 FXYD4 , RASGEF1A T0.074.51 d 7.00E-60.11−0.02980.452rs345963856:141926004 AK097143 T0.05−4.53 d 6.00E-60.01−0.08910.513rs117873418:19102564 LOC100128993 A0.064.91 d 9.00E-70.070.03200.520rs1090488710:17188641 TRDMT1 T0.474.61 d 4.00E-60.81−0.01300.697rs168591403:111792594 TMPRSS7 C0.284.58 d 5.00E-60.11−0.01510.697rs7339483822:30225973 ASCC2 G0.064.44 d 9.00E-60.270.005410.839rs490210014:62549819 SYT16 G0.284.64 d 4.00E-60.23−0.00110.968rs76804684:108304199 DKK2 , PAPSS1 T0.03−5.47 d 5.00E-80.02−0.00250.978Saxena et al . 24 rs20987135:37144574 C5orf42 T0.47−0.253.00E-60.76−0.05430.058rs7401982816:58209274 CSNK2A2 A0.16−0.385.00E-80.05−0.00740.899Gu et al . 25 rs602846620:38129002 DHX35 ANR e 0.1923.00E-70.25−0.04730.103rs6541286:117086378 KPNA5 TNR e 0.1223.00E-60.09−0.05880.151rs6215591:43645411 WDR65 ANR e 0.16…”

Section: Resultsmentioning

confidence: 99%

Genetic Determinants of Telomere Length in African American Youth

Zeiger

White

Eng

et al. 2018

Sci Rep

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Telomere length (TL) is associated with numerous disease states and is affected by genetic and environmental factors. However, TL has been mostly studied in adult populations of European or Asian ancestry. These studies have identified 34 TL-associated genetic variants recently used as genetic proxies for TL. The generalizability of these associations to pediatric populations and racially diverse populations, specifically of African ancestry, remains unclear. Furthermore, six novel variants associated with TL in a population of European children have been identified but not validated. We measured TL from whole blood samples of 492 healthy African American youth (children and adolescents between 8 and 20 years old) and performed the first genome-wide association study of TL in this population. We were unable to replicate neither the 34 reported genetic associations found in adults nor the six genetic associations found in European children. However, we discovered a novel genome-wide significant association between TL and rs1483898 on chromosome 14. Our results underscore the importance of examining genetic associations with TL in diverse pediatric populations such as African Americans.

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Genome-Wide Association Study Identifies Variants in Casein Kinase II ( CSNK2A2 ) to be Associated With Leukocyte Telomere Length in a Punjabi Sikh Diabetic Cohort

Cited by 50 publications

References 53 publications

Genome-wide association study of 25(OH) Vitamin D concentrations in Punjabi Sikhs: Results of the Asian Indian diabetic heart study

Genome-wide association study of 25(OH) Vitamin D concentrations in Punjabi Sikhs: Results of the Asian Indian diabetic heart study

Pro12Ala Polymorphism of the PPARγ2 Gene Interacts With a Mediterranean Diet to Prevent Telomere Shortening in the PREDIMED-NAVARRA Randomized Trial

Genetic Determinants of Telomere Length in African American Youth

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