An outbreak of serogroup C (ST-11) meningococcal disease in Tijuana, Mexico

Chacón-Cruz, Enrique; Monteros, Luz Elena Espinosa-de los; Navarro-Álvarez, Samuel; Aranda-Lozano, Jose Luis; Volker-Soberanes, Maria Luisa; Rivas-Landeros, Rosa Maria; Alvelais-Arzamendi, Ariadna Annete; Vázquez, Julio A.

doi:10.1177/2051013614526592

Cited by 19 publications

(23 citation statements)

References 17 publications

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“…It is relevant to mention that six of the eight patients in the 2012-2013 periods were part of an outbreak during 2013 [5]. Serogroup distribution was as follows: C-32 (62.74%), Y-12 (23.53%), B-5 (9.8%) and Ignored-2 (3.92%).…”

Section: Resultsmentioning

confidence: 99%

“…Only one patient had the tetravalent (A, C, Y, W) meningococcal conjugate vaccine, but this child developed a serogroup B related MD. Median days of illness prior to admission was of two (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). At admission, 47 (92.15%) had meningitis, 24 (47%) purpura, 4 (7.84%) conjunctivitis and 2 (3.92%) pleural effusion (both patients with pleural effusion had a serogroup Y related MD).…”

Section: Resultsmentioning

confidence: 99%

“…Third, shows that MD in the region behaves as an endemic disease, affecting mostly young infants and the presence of an outbreak by MD serogroup C (CT-11) occurred [5].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, from January 30 th March/30 th 2013, we dealt with an outbreak of MD, with 19 culture-confirmed cases and 7 deaths [5] and also published a National active surveillance study in nine Hospitals throughout the country, proving that MD is present in the north part of Mexico [6]. However, Health Authorities still hesitate to vaccinate against MD in the region.…”

Section: Introductionmentioning

confidence: 99%

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Meningococcal Disease in Children: Eleven Years of Active Surveillance in a Mexican Hospital and the Need for Vaccination in the Tijuana Region

Chacón-Cruz¹,

Alvelais-Palacios²,

Lopatynsky-Reyes³

et al. 2017

J Infec Dis Treat

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In Mexico, Meningococcal Disease (MD) is considered to be a rare disease; however, several studies done using active surveillance have proved the opposite. Since October-2005 until September-2016 (eleven years), active surveillance looking for all patients admitted with suspected MD<16 years of age was performed at the Tijuana, Mexico, General Hospital. There were 51 MD cases, with 21 (41.18%) < 2 years old. At admission, 47 (92.15%) had meningitis, 24 (47%) purpura, 4 (7.84%) conjunctivitis and 2 (3.92%) pleural effusion. Serogroup distribution was as follows: C-32 (62.74%), Y-12 (23.53%), B-5 (9.8%) and Ignored-2 (3.92%). Overall mortality was of 13 (25.49%). Among survivors (n=38), 13 (34.2%) developed sequelae. Yearly average MD attack rates were of 7.61 and 2.69 per 100, 000 populations in children<2 and <16 years of age, respectively. MD is endemic in Tijuana, Mexico. Meningococcal vaccination should be seriously considered in the region.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Third, shows that MD in the region behaves as an endemic disease, affecting mostly young infants and the presence of an outbreak by MD serogroup C (CT-11) occurred [5].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Meningococcal Disease in Children: Eleven Years of Active Surveillance in a Mexican Hospital and the Need for Vaccination in the Tijuana Region

Chacón-Cruz¹,

Alvelais-Palacios²,

Lopatynsky-Reyes³

et al. 2017

J Infec Dis Treat

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“…in educational institutions, military barracks, or other crowded, semi-closed places. (Bijlsma et al, 2014;Brehony et al, 2007;Chacon-Cruz et al, 2014;Deghmane et al, 2010;de Lemos et al, 2007;ECDC, 2013;Fazio et al, 2009;Garnier et al, 2011;Simon et al, 2013). Also in Poland between 2006-2009 several outbreaks were recorded as well as an increase of incidence of MenC ST-11CC (Fig.…”

Section: St-11ccmentioning

confidence: 96%

Significance of Meningococcal Hyperinvasive Clonal Complexes and Their Influence on Vaccines Development

Waśko¹,

Hryniewicz²,

Skoczyńska³

2015

Pol J Microbiol

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Neisseria meningitidis is a commensal of human nasopharynx and humans are the only known reservoir and host of this bacterium. It is also known as a dangerous and devastating pathogen, and infection with N. meningitidis may lead to rapidly progressing septicemia or meningitis. These severe infections, called invasive meningococcal disease (IMD), are one of the major public health threats worldwide. IMD may occur sporadically, but also in outbreaks, epidemics, and pandemics. Most of the IMD cases in the world are caused by isolates of genetically related groups, clonal complexes (CC), including those with special epidemiological significance called hyperinvasive clonal complexes. It is still unknown why some of them may persist for decades, whereas other are quickly replaced and disappear. As a consequence, the epidemiological situation of IMD is variable worldwide and greatly depends on the emergence and widespread of clones belonging to hyperinvasive clonal complexes. Their occurrence has serious implications for health policy, requiring often mass immunization campaigns. Paradoxically, alarming situations caused by hyperinvasive CCs stimulated the development and introduction of new vaccines against meningococci. Despite the unquestionable success of these vaccines, isolates of hyperinvasive clones constitute a permanent public health threat, because they are constantly circulating and able to modify their antigenic profiles to escape the host immune response. Therefore, continuous monitoring of meningococcal isolates including thorough molecular typing is indispensable and fundamental for taking appropriate preventive measures.

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Meningococcal Disease Outbreaks: A Moving Target and a Case for Routine Preventative Vaccination

Soumahoro

Abitbol²,

Vicic

et al. 2021

Infect Dis Ther

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An outbreak of serogroup C (ST-11) meningococcal disease in Tijuana, Mexico

Abstract: An outbreak with high mortality of IMD occurred in Tijuana, Mexico. This event and evidence of endemicity should encourage health authorities to evaluate meningococcal vaccination in the region.

Cited by 19 publications

References 17 publications

Meningococcal Disease in Children: Eleven Years of Active Surveillance in a Mexican Hospital and the Need for Vaccination in the Tijuana Region

Meningococcal Disease in Children: Eleven Years of Active Surveillance in a Mexican Hospital and the Need for Vaccination in the Tijuana Region

Significance of Meningococcal Hyperinvasive Clonal Complexes and Their Influence on Vaccines Development

Meningococcal Disease Outbreaks: A Moving Target and a Case for Routine Preventative Vaccination

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