Nature and importance of follicular lymphoma precursors

Early lymphoid lesions: conceptual, diagnostic and clinical challenges

“…Low numbers of clonal B cells with the BCL2 translocation (follicular lymphoma-like B cells, FLLBC) may be detected in benign lymphoid tissue and peripheral blood of healthy subjects, a subject recently reviewed in detail by Mamessier et al 40 FLLBC show preferential homing to the germinal centers of reactive lymph nodes and are nonproliferative. 41 Functionally, and in terms of risk, FLLBC in the blood of healthy individuals, and FLIS/FLBUS as detected histologically appear to be comparable.…”

“…The lack of AID could also explain a reduced capacity for ongoing mutations and limited disease presentation. 40 DFL has an indolent clinical course, with more than 95% of patients showing no systemic involvement or progression after a median follow up of 77 months. There were no significant differences in survival or time to progression between treated and untreated patients, supporting the view that in the absence of disease progression, judicious follow up and observation is preferred to aggressive therapy.…”

Contiguous follicular lymphoma and follicular lymphoma in situ harboring N-glycosylated sites

“…This is in line with the usually indolent progression of the disease, and the genomic instability observed in FLIS cells, which can engage FL precursor cells either in an evolutionary malignant process, or to an evolutionary dead end. 4 We report the case of a 35-year old male patient who presented with a cervical adenopathy. Histological examination of the excised LN displayed an altered architecture suggestive of FL, consisting of high number of monomorphic large follicles, uniformly spread in the cortical and medullary areas.…”

“…Emilie Mamessier,1,2,3 Charlotte Drevet, 1,2,3 Florence Broussais-Guillaumot, 3 Marie-Laure Mollichella, 1,2,3 Sylvain Garciaz, 1,2,3 Sandrine Roulland, 1,2,3 Maxime Benchetrit, 4 Bertrand Nadel, 1 …”

MYD88 L265P mutation analysis helps define nodal lymphoplasmacytic lymphoma

“…Overall, the clinicopathologic features in these four cases favored classification as lymphoplasmacytic lymphoma with a vaguely nodular architecture and variably prominent follicular colonization. Although follicular colonization is frequently seen in marginal zone lymphoma, this phenomenon may also be seen in other B-cell lymphomas, including follicular lymphoma [28][29][30][31] and mantle cell lymphoma. 32 In the 2009 Society for Hematopathology/European Association of Hematopathology workshop, cases of putative lymphoplasmacytic lymphoma with follicular colonization were accepted as bona fide lymphoplasmacytic lymphoma by some, but not all, members of the expert review panel.…”