Adipsic Diabetes Insipidus in Pediatric Patients

Januś, Dominika; Wójcik, Małgorzata; Zygmunt-Górska, Agata; Wyrobek, Łukasz; Urbanik, Andrzej; Starzyk, Jerzy

doi:10.1007/s12098-014-1421-8

Cited by 12 publications

(6 citation statements)

References 21 publications

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“…Routine adipsia evaluation, combined with water deprivation and vasopressin tests (if necessary), is critical for the diagnosis and treatment of ADI. The fluid intake in patients diagnosed with ADI should be supervised daily, based on the constant volume of oral fluids, daily measurement of fluid balance, body weight, and sodium level (12), especially in patients who are physically unable to care for themselves.…”

Section: Discussionmentioning

confidence: 99%

Adipsic Diabetes Insipidus: A Single-Center Case Series

et al. 2017

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Adipsic diabetes insipidus (ADI) is a rare and challenging complication secondary to several neurosurgical procedures. It can lead to severe hyperosmolarity and is associated with high rates of morbidity and mortality. Considering the variable time of thirst sensation recovery, long-term treatment is accompanied with the risk of extreme extracellular osmolality fluctuations. Herein, we report 3 cases of this rare presentation of hypothalamic injury.

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Section: Discussionmentioning

confidence: 99%

Adipsic Diabetes Insipidus: A Single-Center Case Series

et al. 2017

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“…In these cases there is high risk of both hypernatremia and hyponatremia, as patients cannot adjust fluid intake according to thirst (176). After careful titration (requiring frequent weighing and sodium measurements), we suggest a fixed dose of DDAVP and a constant amount of fluid intake together with consistent environmental temperature and humidity conditions (182). (183,184).…”

Section: May 4 2016mentioning

confidence: 99%

Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline

Fleseriu

Hashim

Karavitaki

et al. 2016

The Journal of Clinical Endocrinology &Amp; Metabolism

684

677

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Using an evidence-based approach, this guideline addresses important clinical issues regarding the evaluation and management of hypopituitarism in adults, including appropriate biochemical assessments, specific therapeutic decisions to decrease the risk of co-morbidities due to hormonal over-replacement or under-replacement, and managing hypopituitarism during pregnancy, pituitary surgery, and other types of surgeries.

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“…In the medical the literature, there were 100 cases reporting Adipsia combining diabetes insipidus. To the best of our knowledge, there were only three case reports documenting adipsic diabetes insipidus with astrocytoma tumor [6][7][8] and our case is the fourth one. Table 3 summarized similarities and differences between the cases.…”

Section: Case Presentationmentioning

confidence: 76%

Adipsic Diabetes Insipidus After Second Resection of A Hypothamic Astrocytoma

Elamin

Alanazi

Saeed

et al. 2020

AACE Clinical Case Reports

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Objective We are reporting a case of adipsic diabetes insipidus (ADI) post astrocytoma resection. Method Clinical and laboratory data are presented Results 16-year-old female with a history of incompletely resected hypothalamic astrocytoma admitted with headache. Head MRI showed interval increase in suprasellar lesion with extension to the third ventricle. Following second stage resection, she developed increased urine output with diluted urine resulting in negative fluid balance, however, she was unable to sense thirst. Blood tests showed serum sodium of 155 mEq/dl (136–145), serum osmolality at 321 mOs/kg ( 285–295 ) and urine osmolality of 128 mOsm/kg (300–1600 ). Serum creatinine and potassium were normal. Pituitary hormone profile were normal : Growth Hormone 0.171 ng/ml (0.123–8.05), LH 3.44 miu/ml (7.59–89.08), FSH 5.60 miu/ml (2.55–16.69) TSH 2.9 miu/ml (0.35–4.94), Free Thyroxine 0.92 ng/dl (0.7–1.48), ACTH 19.56 pg/ml (7.2–63.3) and Prolactin 7.25 ng/ml (5.18–26.53). The patient was treated with Desmopressin Acetate 120 mcg tablets twice daily with a fixed fluid intake of 1.5 to 2.0 liters/day with closed monitoring of fluid intake, output and body weight. Response was good with gradual reduction of serum sodium level of around 7–9 mEq/L/Day. Conclusions Adipsic diabetes insipidus is a rare entity of central diabetes insipidus, where the absence of polydipsia can be challenging in diagnosing and managing the condition. Cases of ADI are likely under reported and clinicians need to be aware of this condition

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Adipsic Diabetes Insipidus in Pediatric Patients

Cited by 12 publications

References 21 publications

Adipsic Diabetes Insipidus: A Single-Center Case Series

Adipsic Diabetes Insipidus: A Single-Center Case Series

Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline

Adipsic Diabetes Insipidus After Second Resection of A Hypothamic Astrocytoma

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