Ginkgo biloba extract postconditioning reduces myocardial ischemia reperfusion injury

Abstract

ABSTRACT. We examined the protective effects of Ginkgo biloba extract (EGb761) postconditioning on myocardial ischemia reperfusion injury in rabbits. Four groups of 8 white rabbits were allocated to: pseudo surgery group: the left coronary was lined without blocking for 160 min after thoracotomy; ischemia and reperfusion group (IR): the left anterior descending coronary artery was blocked for 40 min and reperfused for 120 min; ischemic postconditioning group: the left anterior descending artery was ligated for 40 min, reopened for 30 s and ligated for 30 s, repeated three times, and then reperfused for 120 min; EGb761 postconditioning group (E): 100 mg/kg EGb761 was injected into a vein while the left coronary artery was opened for 1 min. The reperfusion took 120 min. Internal carotid arterial blood in each group was collected for cTnI measurement at five times: 20 min before occlusion of the left coronary artery, 20 min after left coronary artery occlusion, 40 min after left coronary artery occlusion, 1 h after myocardial reperfusion, and 2 h after myocardial reperfusion. Superoxide dismutase (SOD), malondialdehyde (MDA) in the centrifuged blood and myocardial infarction area were measured at the end of reperfusion. We found that the serum cTnI concentrations in the E group during reperfusion decreased significantly compared with those in the IR group. The infarction area was significantly lower in the E group than that in the IR group. The SOD activity in the E group was increased compared with that in the IR group; the MDA content decreased significantly in the E group compared with that in the IR group. We conclude that G. biloba extract postconditioning had myocardial protection effects by reducing the generation of oxygen-free radicals and increasing the antioxidant capacity of the myocardial cells.

Ginkgo biloba extract may alleviate viral myocarditis by suppression of S100A4 and MMP‐3

“…Modern medicinal uses for Ginkgo are solely derived from leaf extracts, the main components of which are flavones and terpene lactones. Ginkgo biloba extract has been demonstrated to have anti‐inflammatory, antioxidant and antiarrhythmic activities and has been widely used in the prevention and therapy of cardiovascular diseases . The present study investigated the therapeutic effects of Ginkgo biloba extract on VMC and explored the potential mechanisms.…”

“…Ginkgo biloba has existed on earth for 250 million years, and is called “living fossil.” Utilizing Ginkgo biloba leaves as an herbal medicine for the treatment of various diseases can be traced back to thousands of years in China . Ginkgo biloba extract has been demonstrated to protect against cardiac ischemia‐reperfusion injury, and have antiarrhythmic effects on cardiac reperfusion‐induced arrhythmias . A recent study has reported that Ginkgo biloba extract could inhibit rat myocardial remodeling after acute myocardial infarction via decreasing the expression of type I collagen, MMP‐2, and MMP‐9 proteins in myocardial cells .…”

“…16 Ginkgo biloba extract has been demonstrated to protect against cardiac ischemia-reperfusion injury, and have antiarrhythmic effects on cardiac reperfusioninduced arrhythmias. 17,18 A recent study has reported that Ginkgo biloba extract could inhibit rat myocardial remodeling after acute myocardial infarction via decreasing the expression of type I collagen, MMP-2, and MMP-9 proteins in myocardial cells. 19 However, its therapeutic effects on VMC remain unknown.…”

Ginkgo biloba extract EGb761 attenuates brain death-induced renal injury by inhibiting pro-inflammatory cytokines and the SAPK and JAK-STAT signalings

“…The molecular mechanisms of neuroprotective effects of EGb761 are of multiple-aspects, including anti-apoptosis, anti-inflammatory, protecting mitochondria24, etc. Accumulating evidences also demonstrate that EGb761 possesses good protective effect on cardiovascular diseases252627. Recent study showed that EGb761 exerts its anti-inflammatory effect by inhibiting several pro-inflammatory mediators and signaling pathways28.…”

Effect of adjuvant therapy with ginkgo-damole on apoptosis, nerve injury and platelet aggregation of patients with acute cerebral infarction

“…The effective components of ginkgo-diyidamolum include extracts of traditional Chinese medicine, folium ginkgo, and western medicine, dipyridamole. The former one can be specifically against the platelet activating factor [15][16][17], while the latter one can inhibit adenosine diphosphate and thromboxane [18]. TRAIL is also included in tumor necrosis factor receptor which can induce apoptosis through two cascade amplifier channels, nuclear factor-kappa B and caspase [22][23][24].…”