Potential lack of “standardized” processing techniques for production of allogeneic and xenogeneic bone blocks for application in humans

Ghanaati, Shahram; Barbeck, Mike; Booms, Patrick; Lorenz, Julia; Kirkpatrick, Charles James; Sader, Robert

doi:10.1016/j.actbio.2014.04.017

Cited by 73 publications

(95 citation statements)

References 24 publications

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“…However, available amounts are limited, its resorption pattern is difficult to predict, and the additional surgery for harvesting causes patient discomfort and introduces risks of possible complications [3,4,5]. Allogenic and xenogenic bones are obtained from corpses and animals, respectively, and thus, no harvesting is required and availability is not an issue, but immune rejection and cross infection are possible [6]. Accordingly, alloplast grafting is becoming increasingly popular, and calcium phosphates are commonly used because their chemical compositions are similar to that of natural bone [7,8,9,10,11].…”

Section: Introductionmentioning

confidence: 99%

Effects of BMP-2 Delivery in Calcium Phosphate Bone Graft Materials with Different Compositions on Bone Regeneration

et al. 2016

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This study was undertaken to investigate the effect of loading rhBMP-2 onto biphasic calcium phosphate (BCP) and calcium pyrophosphate (CPP) on bone regeneration, and to examine the efficacies of BCP and CPP as rhBMP-2 carriers. Specimens were divided into the BCP, CPP, BCP/BMP, and CPP/BMP groups; BCP and CPP were in granules and not coated with rhBMP-2. BCP/BMP and CPP/BMP were prepared as discs, which were treated with rhBMP-2 and collagen. Physical and biological features were investigated using in-vitro and in-vivo tests. New bone area percentages (%) in the BCP/BMP and CPP/BMP groups were significantly greater than in the BCP and CPP groups. At weeks 4 and 8 post-implantation, CPP/BMP showed the most new bone growth. Within the limitations of this study, treatment of BCP and CPP with rhBMP-2 significantly enhanced bone regeneration. CPP was found to be a suitable carrier for rhBMP-2.

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Section: Introductionmentioning

confidence: 99%

Effects of BMP-2 Delivery in Calcium Phosphate Bone Graft Materials with Different Compositions on Bone Regeneration

et al. 2016

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“…Além disso, por meio de imuno-histoquimica não são encontrados macrófagos próximos ao biomaterial. Deste modo, é possível considerar que mesmo diante da sugestão de remanescentes orgânicos no Bio-Oss ® , este biomaterial xenógeno é biocompatível, uma vez que ele não é reconhecido como um corpo estranho (TAPETY, 2004 (GHANAATI, 2014). Embora a utilização de implantes alogênicos e xenogênicos tenha mostrado resultados clínicos satisfatórios (HOUSER, 2001), faltam informações aprofundadas e detalhadas sobre a composição final e a estrutura microscópica desses biomateriais.…”

Section: Implante Alógeno Ou Homógenounclassified

“…Por outro lado, há necessidade da presença da matriz óssea extracelular que sustente/conduza o processo de remodelação óssea natural, possibilitando a formação de um novo osso (HSIONG, 2006). Além disso, há relatos de que o processo de purificação do material pode resultar em fracasso desses "andaimes naturais" por diminuir a osteocondução (GHANAATI, 2014).…”

Section: Implante Alógeno Ou Homógenounclassified

Substitutos Ósseos Alógenos E Xenógenos Comparados Ao Enxerto Autógeno: Reações Biológicas

Rodolfo

Machado

Betoni-Júnior³

et al. 2017

RBM

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Palavras-chave: Enxerto Autólogo; Xenoenxerto; Aloenxerto; Reações Biológicas. Allogenous and xenogenous bone substitutes compared to autogenous bone graft: biologycal reactions AbstractThe implant supported rehabilitation of edentulous patients is hampered by insufficient bone volume, thus, requiring a prior bone reconstruction. Autogenous bone is still the "gold standard" biomaterial, which is effective in bone regeneration process, contains viable cells and doesn't transmit infectious diseases nor triggers immune responses. Moreover, it presents rapid incorporation and consolidation. However, this type of graft has disadvantages such as increased morbidity and limited availability. In view of the constant search for bone substitutes that may have properties similar to autogenous bone, but that do not require a second surgical site, the use of allogeneic (from individuals of the same species, but genetically Substitutos ósseos alógenos e xenógenos comparados... RODOLFO et al. 96 97

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“…Many strategies to promote bone regeneration exist, most commonly through the use of autografts and allografts. However, these strategies involve extensive processing of the bone substitute and residual material can be difficult to completely remove, causing an immune response (1,2). The impact of the immune system on overall outcome of implanted materials is of paramount importance: chronic and persistent inflammation can lead to fibrous tissue, limited bone formation, and possible resorption of the bone (3,4).…”

Section: Introductionmentioning

confidence: 99%

Mineralized collagen scaffolds fabricated with amniotic membrane matrix increase osteogenesis under inflammatory conditions

Dewey

Johnson

Slater

et al. 2020

Preprint

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ABSTRACTDefects in craniofacial bones occur congenitally, after high-energy impacts, and during the course of treatment for stroke and cancer. These injuries are difficult to heal due to the overwhelming size of the injury area and the inflammatory environment surrounding the injury. Significant inflammatory response after injury may greatly inhibit regenerative healing. We have developed mineralized collagen scaffolds that can induce osteogenic differentiation and matrix biosynthesis in the absence of osteogenic media or supplemental proteins. The amniotic membrane is derived from placentas and has been recently investigated as an extracellular matrix to prevent chronic inflammation. Herein, we hypothesized that a mineralized collagen-amnion composite scaffold could increase osteogenic activity in the presence of inflammatory cytokines. We report mechanical properties of a mineralized collagen-amnion scaffold and investigated osteogenic differentiation and mineral deposition of porcine adipose derived stem cells within these scaffolds as a function of inflammatory challenge. Incorporation of amniotic membrane matrix promotes osteogenesis similarly to un-modified mineralized collagen scaffolds, and increases in mineralized collagen-amnion scaffolds under inflammatory challenge. Together, these findings suggest that a mineralized collagen-amnion scaffold may provide a beneficial environment to aid craniomaxillofacial bone repair, especially in the course of defects presenting significant inflammatory complications.

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Potential lack of “standardized” processing techniques for production of allogeneic and xenogeneic bone blocks for application in humans

Cited by 73 publications

References 24 publications

Effects of BMP-2 Delivery in Calcium Phosphate Bone Graft Materials with Different Compositions on Bone Regeneration

Effects of BMP-2 Delivery in Calcium Phosphate Bone Graft Materials with Different Compositions on Bone Regeneration

Substitutos Ósseos Alógenos E Xenógenos Comparados Ao Enxerto Autógeno: Reações Biológicas

Mineralized collagen scaffolds fabricated with amniotic membrane matrix increase osteogenesis under inflammatory conditions

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