Tissue Border Enhancement by inversion recovery MRI at 7.0 Tesla

Costagli, Mauro; Kelley, Douglas A.C.; Symms, Mark Roger; Biagi, Laura; Stara, Riccardo; Maggioni, Eleonora; Tiberi, Gianluigi; Barba, Carmen; Guerrini, Renzo; Cosottini, Mirco; Tosetti, Michela

doi:10.1007/s00234-014-1365-8

Cited by 14 publications

(17 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this case, MP2 + INV1 alone revealed gray matter increase in the area around the right amygdala, which is concordant to the clinical hypothesis. Improved performance by adding INV1 is in line with recent studies, which show that lesion detection could be enhanced by highlighting GM–WM boundaries (Costagli et al, ; Mougin et al, ).…”

Section: Discussionsupporting

confidence: 84%

“…The most likely reason for this is the “dark rim” of hypointense signal at the GM–WM junction. This “dark rim” has also been observed in the previous studies at 7 T using acquisition techniques such as null point imaging and tissue border enhancement by inversion recovery, facilitating enhanced visualization of tissue boundaries of interests (Costagli et al, ; Mougin et al, ). This effect is likely due to similar longitudinal magnetizations of GM and WM but with opposite polarities (Pitiot, Totman, & Gowland, ).…”

Section: Discussionsupporting

confidence: 58%

“…One might also speculate that a thinner cortical segmentation might as well be sensitive toward lesions with a blurred GM–WM junction. The hypointense GM–WM boundary rim has been observed at inversion times between 200 and 1,000 ms with different sequence parameter optimizations at variable field strengths of 3 and 7 T (Costagli et al, ; Marques et al, ; Mougin et al, ; Pitiot et al, ). Hence, the selection of TI for INV1 needs to be carefully considered when planning an MP2RAGE study, as this can clearly influence the segmentation.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

MP2RAGE multispectral voxel‐based morphometry in focal epilepsy

Kotikalapudi

Martin

Erb³

et al. 2019

Human Brain Mapping

View full text Add to dashboard Cite

We assessed the applicability of MP2RAGE for voxel‐based morphometry. To this end, we analyzed its brain tissue segmentation characteristics in healthy subjects and the potential for detecting focal epileptogenic lesions (previously visible and nonvisible). Automated results and expert visual interpretations were compared with conventional VBM variants (i.e., T1 and T1 + FLAIR). Thirty‐one healthy controls and 21 patients with focal epilepsy were recruited. 3D T1‐, T2‐FLAIR, and MP2RAGE images (consisting of INV1, INV2, and MP2 maps) were acquired on a 3T MRI. The effects of brain tissue segmentation and lesion detection rates were analyzed among single‐ and multispectral VBM variants. MP2‐single‐contrast gave better delineation of deep, subcortical nuclei but was prone to misclassification of dura/vessels as gray matter, even more than conventional‐T1. The addition of multispectral combinations (INV1, INV2, or FLAIR) could markedly reduce such misclassifications. MP2 + INV1 yielded generally clearer gray matter segmentation allowing better differentiation of white matter and neighboring gyri. Different models detected known lesions with a sensitivity between 60 and 100%. In non lesional cases, MP2 + INV1 was found to be best with a concordant rate of 37.5%, specificity of 51.6% and concordant to discordant ratio of 0.60. In summary, we show that multispectral MP2RAGE VBM (e.g., MP2 + INV1, MP2 + INV2) can improve brain tissue segmentation and lesion detection in epilepsy.

show abstract

Section: Discussionsupporting

confidence: 84%

Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

MP2RAGE multispectral voxel‐based morphometry in focal epilepsy

Kotikalapudi

Martin

Erb³

et al. 2019

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…This effect is achieved by setting imaging parameters so that the neighboring tissues have magnetization with equal magnitude but out of phase; therefore, the voxels containing a mixture of each tissue (ie, the tissue interface) possess minimal net signal. 37 Therefore, the hypointense line-marking tissue interface produced by TBE does not reflect any specific fiber structure. Details of imaging parameters for 3T and 7T imaging are shown in On-line Table 2.…”

Section: Methodsmentioning

confidence: 99%

Ultra-High-Field MR Imaging in Polymicrogyria and Epilepsy

Ciantis

Barkovich

Cosottini

et al. 2014

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

BACKGROUND AND PURPOSE Polymicrogyria is a malformation of cortical development that is often identified in children with epilepsy or delayed development. We investigated in vivo the potential of 7T imaging in characterizing polymicrogyria to determine whether additional features could be identified. MATERIALS AND METHODS Ten adult patients with polymicrogyria previously diagnosed by using 3T MR imaging underwent additional imaging at 7T. We assessed polymicrogyria according to topographic pattern, extent, symmetry, and morphology. Additional imaging sequences at 7T included 3D T2* susceptibility-weighted angiography and 2D tissue border enhancement FSE inversion recovery. Minimum intensity projections were used to assess the potential of the susceptibility-weighted angiography sequence for depiction of cerebral veins. RESULTS At 7T, we observed perisylvian polymicrogyria that was bilateral in 6 patients, unilateral in 3, and diffuse in 1. Four of the 6 bilateral abnormalities had been considered unilateral at 3T. While 3T imaging revealed 2 morphologic categories (coarse, delicate), 7T susceptibility-weighted angiography images disclosed a uniform ribbonlike pattern. Susceptibility-weighted angiography revealed numerous dilated superficial veins in all polymicrogyric areas. Tissue border enhancement imaging depicted a hypointense line corresponding to the gray-white interface, providing a high definition of the borders and, thereby, improving detection of the polymicrogyric cortex. CONCLUSIONS 7T imaging reveals more anatomic details of polymicrogyria compared with 3T conventional sequences, with potential implications for diagnosis, genetic studies, and surgical treatment of associated epilepsy. Abnormalities of cortical veins may suggest a role for vascular dysgenesis in pathogenesis.

show abstract

“…We used a dedicated epilepsy research MRI protocol including the following sequences: 3D T1W FSPGR, 3D susceptibility-weighted angiography (SWAN), 2D T 2 *-weighted targeted dual-echo gradientrecalled echo (GRE), 2D T2W FSE, 2D gray-white matter tissue border enhancement (TBE) FSE-IR. 24 GRE and TBE sequences were targeted based on the localization of the SOZ. Since July 2014, 3D magnetization-prepared (MP)-FLAIR sequence 25 was included in the protocol.…”

Section: Mri Acquisitionmentioning

confidence: 99%

7TMRIin focal epilepsy with unrevealing conventional field strength imaging

Ciantis

Barba

Tassi³

et al. 2016

Epilepsia

Self Cite

133

127

View full text Add to dashboard Cite

SUMMARYObjective: To assess the diagnostic yield of 7T magnetic resonance imaging (MRI) in detecting and characterizing structural lesions in patients with intractable focal epilepsy and unrevealing conventional (1.5 or 3T) MRI. Methods: We conducted an observational clinical imaging study on 21 patients (17 adults and 4 children) with intractable focal epilepsy, exhibiting clinical and electroencephalographic features consistent with a single seizure-onset zone (SOZ) and unrevealing conventional MRI. Patients were enrolled at two tertiary epilepsy surgery centers and imaged at 7T, including whole brain (three-dimensional [3D] T 1 -weighted [T1W] fast-spoiled gradient echo (FSPGR), 3D susceptibility-weighted angiography [SWAN], 3D fluid-attenuated inversion recovery [FLAIR]) and targeted imaging (2D T 2 *-weighted dual-echo gradient-recalled echo [GRE] and 2D gray-white matter tissue border enhancement [TBE] fast spin echo inversion recovery [FSE-IR]). MRI studies at 1.5 or 3T deemed unrevealing at the referral center were reviewed by three experts in epilepsy imaging. Reviewers were provided information regarding the suspected localization of the SOZ. The same team subsequently reviewed 7T images. Agreement in imaging interpretation was reached through consensus-based discussions based on visual identification of structural abnormalities and their likely correlation with clinical and electrographic data. Results: 7T MRI revealed structural lesions in 6 (29%) of 21 patients. The diagnostic gain in detection was obtained using GRE and FLAIR images. Four of the six patients with abnormal 7T underwent epilepsy surgery. Histopathology revealed focal cortical dysplasia (FCD) in all. In the remaining 15 patients (71%), 7T MRI remained unrevealing; 4 of the patients underwent epilepsy surgery and histopathologic evaluation revealed gliosis. Significance: 7T MRI improves detection of epileptogenic FCD that is not visible at conventional field strengths. A dedicated protocol including whole brain FLAIR and GRE images at 7T targeted at the suspected SOZ increases the diagnostic yield.

show abstract

Tissue Border Enhancement by inversion recovery MRI at 7.0 Tesla

Cited by 14 publications

References 27 publications

MP2RAGE multispectral voxel‐based morphometry in focal epilepsy

MP2RAGE multispectral voxel‐based morphometry in focal epilepsy

Ultra-High-Field MR Imaging in Polymicrogyria and Epilepsy

7TMRIin focal epilepsy with unrevealing conventional field strength imaging

Contact Info

Product

Resources

About