Nonsteroidal anti-inflammatory drugs and antihypertensives: how do they relate?

Khatchadourian, Zovinar Der; Moreno-Hay, Isabel; Leeuw, Reny de

doi:10.1016/j.oooo.2014.02.028

Cited by 17 publications

(16 citation statements)

References 51 publications

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“…The interaction between NSAIDs and antihypertensive drugs mainly depends on the role that prostaglandins play in the antihypertensive mechanism, 18,19 while the antihypertensive effect of CCBs is not dependent on the action of prostaglandins 20 . Theoretically, CCBs should be less affected by NSAIDs, and previous researches also supported this 21–23 . However, our results were the opposite.…”

Section: Discussionsupporting

confidence: 65%

The effects of different antihypertensive drugs on pain and joint space width of knee osteoarthritis – A comparative study with data from Osteoarthritis Initiative

Zeng

Nie

et al. 2021

J of Clinical Hypertension

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Hypertension was one common comorbidity of knee osteoarthritis (KOA), but the effect of different types of antihypertensive drugs on pain and joint space width (JSW) was unclear and not compared. Four hundred ninety KOA patients using one of the beta-blockers, ACE inhibitors, angiotensin receptor blockers, Calcium channel blockers (CCBs), or thiazide diuretics were followed for four years. The blood pressure, cumulative knee replacement rate, Womac pain, and JSW were compared among groups.All data were from the Osteoarthritis Initiative project. The CCBs group has the highest systolic blood pressure, replacement rate, and pain score at most visit timepoints.At baseline, the CCBs group was with significantly higher pain score than the betablockers group (3.3 vs 1.3, p < .05), the angiotensin receptor blockers group (3.3 vs 1.4, p < .05), and the thiazide diuretics group (3.3 vs 1.6, p < .05) in male; the CCBs group was with significantly higher pain score than the beta-blockers group (3.8 vs 2.0, p < .01), and the angiotensin receptor blockers group (3.8 vs 2.2, p < .05) in female.The results of females at 36 months were similar to the baseline. Among the common antihypertensive drugs, CCBs were associated with high replacement rates, high pain scores, and less JSW in KOA patients.

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Section: Discussionsupporting

confidence: 65%

The effects of different antihypertensive drugs on pain and joint space width of knee osteoarthritis – A comparative study with data from Osteoarthritis Initiative

Zeng

Nie

et al. 2021

J of Clinical Hypertension

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“…Therefore, all NSAIDs are able to increase blood pressure and also to cause/worsen heart failure. On the other hand, the imbalance between the thromboxane A 2 and the prostacyclin system is influenced differently based on the degree of inhibition of COX 1/2, duration of action, and reversibility of inhibition. Regarding NSAIDs, only acetylsalicylic acid in low doses (and rarely indobufen) is used clinically for protection against atherothrombosis .…”

Section: Drug Affecting Primarily the Vascular Systemmentioning

confidence: 99%

Comprehensive review of cardiovascular toxicity of drugs and related agents

Mladěnka

Applová

Patočka

et al. 2018

Medicinal Research Reviews

203

120

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Cardiovascular diseases are a leading cause of morbidity and mortality in most developed countries of the world. Pharmaceuticals, illicit drugs, and toxins can significantly contribute to the overall cardiovascular burden and thus deserve attention. The present article is a systematic overview of drugs that may induce distinct cardiovascular toxicity. The compounds are classified into agents that have significant effects on the heart, blood vessels, or both. The mechanism(s) of toxic action are discussed and treatment modalities are briefly mentioned in relevant cases. Due to the large number of clinically relevant compounds discussed, this article could be of interest to a broad audience including pharmacologists and toxicologists, pharmacists, physicians, and medicinal chemists. Particular emphasis is given to clinically relevant topics including the cardiovascular toxicity of illicit sympathomimetic drugs (e.g., cocaine, amphetamines, cathinones), drugs that prolong the QT interval, antidysrhythmic drugs, digoxin and other cardioactive steroids, beta‐blockers, calcium channel blockers, female hormones, nonsteroidal anti‐inflammatory, and anticancer compounds encompassing anthracyclines and novel targeted therapy interfering with the HER2 or the vascular endothelial growth factor pathway.

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“…NSAIDs also found to interact with the SSRI (selective serotonin reuptake inhibitors) to increase the risk of upper gastrointestinal bleeding as well as bleeding and postoperative. [25][26][27] Acetaminophen has very few drug interactions. Carbamazepine as metabolic inducer drug can reduce levels of acetaminophen.…”

Section: Drug Interaction Of Analgesicsmentioning

confidence: 99%

Analgesics in dentistry

Hassan¹,

Bhateja²,

Arora³

et al. 2020

IJMPO

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Pain is a defensive admonition sign enacted by tissue harm during various neurotic procedures. The clinical indication of pain is individual, multifactorial and extremely intricate and requires the execution of sound pharmacological methodologies. The treatment of odontogenic pain is engaged in the help of pain as well as in the concealment of reasons for pain, principally the aggravation. Going about as inhibitors of pain component, analgesics are utilized for indicative treatment of pain. There are a few gatherings of pain relieving drugs utilized in dentistry practice and most incessant are nonsteroidal calming drugs (NSAIDs) and aniline analgesics. The contemporary procedures for the treatment of odontogenic pain are engaged in pain relieving drug mixes, which are increasingly viable and have a superior security profile. Ibuprofen and acetaminophen operators are viewed as best quality level of dental absense of pain for mellow to direct force of pain, while in moderate to serious pain the utilization of individual narcotic analgesics or blend of narcotic and nonopioid analgesics is suggested.

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Nonsteroidal anti-inflammatory drugs and antihypertensives: how do they relate?

Cited by 17 publications

References 51 publications

The effects of different antihypertensive drugs on pain and joint space width of knee osteoarthritis – A comparative study with data from Osteoarthritis Initiative

The effects of different antihypertensive drugs on pain and joint space width of knee osteoarthritis – A comparative study with data from Osteoarthritis Initiative

Comprehensive review of cardiovascular toxicity of drugs and related agents

Analgesics in dentistry

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