Use of Artemisinin and its Derivatives to treat HPV-Infected/Transformed Cells and Cervical Cancer: A Review

Goodrich, Sarah; Schlegel, Christina; Wang, Guixang; Belinson, Jerome L.

doi:10.2217/fon.13.228

Cited by 17 publications

(10 citation statements)

References 44 publications

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“…Artesunate is one of the semi-synthetic derivatives of artemisinin that has good water solubility and antimalarial effects (6). In addition, artemisinin and its derivatives possess anti-tumor activities, anti-inflammatory functions, and anti-fibrotic effects in diverse diseases (7 –9). For instance, artesunate induced cell apoptosis in lung adenocarcinoma and esophageal cancer (10,11), and it induced radiosensitivity in cervical cancer cells (12).…”

Section: Introductionmentioning

confidence: 99%

Artesunate promotes Th1 differentiation from CD4+ T cells to enhance cell apoptosis in ovarian cancer via miR-142

Chen

Zhang

et al. 2019

Braz J Med Biol Res

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The aim of this study was to evaluate the influence of artesunate on Th1 differentiation and its anti-tumor effect on ovarian cancer. A Murine ovarian cancer model was established by ID8 cells transplantation. The expression of miR-142 and Sirt1 proteins in peripheral CD4 + T cells were quantified with qRT-PCR and western blot, respectively. Peripheral CD4 + T cells were induced for Th1 differentiation. The percentages of apoptosis of Th1/CD4 + T cells and ovarian cancer cells were analyzed by flow cytometry. The IFN-γ level was examined through enzyme-linked immunosorbent assay. Artesunate promoted miR-142 expression in peripheral CD4 + T cells and Th1 differentiation from CD4 + T cells. Artesunate promoted cell apoptosis of ovarian cancer cells by inducing Th1 differentiation. By up-regulating miR-142, artesunate suppressed Sirt1 level and promoted Th1 differentiation. Artesunate enhanced the pro-apoptotic effects of Th1 cells on ovarian cancer via the miR-142/Sirt1 pathway. Artesunate promoted Th1 differentiation from CD4 + T cells by down-regulating Sirt1 through miR-142, thereby enhancing cell apoptosis in ovarian cancer.

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Section: Introductionmentioning

confidence: 99%

Artesunate promotes Th1 differentiation from CD4+ T cells to enhance cell apoptosis in ovarian cancer via miR-142

Chen

Zhang

et al. 2019

Braz J Med Biol Res

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“…In yeast, artemisinin is known to affect the cell cycle as well as mitochondrial function 29 , 30 . Furthermore, artemisinin has well-established effects on cancer cell cycle progression 31 – 33 . Our functional annotation supports both of these diverse roles for artemisinin because our artemisinin-related natural product (NP266) was annotated with 2 different biological process predictions: mitochondria cristae formation and microtubule cytoskeleton organization ( Supplementary Dataset 8 ); however, the artemisinin derivatives that contain a relatively long side chain, extending from the three-ring core, have stronger predictions to a mitosis-related rather than a mitochondrial bioprocess-level target.…”

Section: Resultsmentioning

confidence: 99%

Functional annotation of chemical libraries across diverse biological processes

et al. 2017

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Chemical-genetic approaches offer the potential for unbiased functional annotation of chemical libraries. Mutations can alter the response of cells to a compound, revealing chemical-genetic interactions that can elucidate a compound’s mode of action. We developed a highly parallel and unbiased yeast chemical-genetic screening system involving three key components. First, in a drug-sensitive genetic background, we constructed an optimized, diagnostic mutant collection that is predictive for all major yeast biological processes. Second, we implemented a multiplexed (768-plex) barcode sequencing protocol, enabling assembly of thousands of chemical-genetic profiles. Finally, based on comparison of the chemical-genetic profiles with a compendium of genome-wide genetic interaction profiles, we predicted compound functionality. Applying this high-throughput approach, we screened 7 different compound libraries and annotated their functional diversity. We further validated biological process predictions, prioritized a diverse set of compounds, and identified compounds that appear to have dual modes of action.

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“…Finally, artemisinin and its derivatives are known to diminish several cancer types by modulating autophagy 124 . Thus, these compounds have been shown as cytotoxic in HPV‐infected and transformed cells 125 . These works propose that autophagy is a promising target in cancer treatment by means of diverse compounds.…”

Section: Targeting Autophagy As Treatment In Hpv‐related Cancersmentioning

confidence: 99%

Regulation of autophagy by high‐ and low‐risk human papillomaviruses

Aranda-Rivera

Cruz-Gregorio

Briones-Herrera

et al. 2020

Reviews in Medical Virology

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Summary While high‐risk human papillomavirus (HR‐HPV) infection is related to the development of cervical, vulvar, anal, penile and oropharyngeal cancer, low‐risk human papillomavirus (LR‐HPV) infection is implicated in about 90% of genital warts, which rarely progress to cancer. The carcinogenic role of HR‐HPV is due to the overexpression of HPV E5, E6 and E7 oncoproteins which target and modify cellular proteins implicated in cell proliferation, apoptosis and immortalization. LR‐HPV proteins also target and modify some of these processes; however, their oncogenic potential is lower than that of HR‐HPV. HR‐HPVs have substantial differences with LR‐HPVs such as viral integration into the cell genome, induction of p53 and retinoblastoma protein degradation, alternative splicing in HR‐HPV E6‐E7 open reading frames, among others. In addition, LR‐HPV can activate the autophagy process in infected cells while HR‐HPV infection deactivates it. However, in cancer HR‐HPV might reactivate autophagy in advance stages. Autophagy is a catabolic process that maintains cell homoeostasis by lysosomal degradation and recycling of damaged macromolecules and organelles; nevertheless, depending upon cellular context autophagy may also induce cell death. Therefore, autophagy can contribute either as a promotor or as a suppressor of tumours. In this review, we focus on the role of HR‐HPV and LR‐HPV in autophagy during viral infection and cancer development. Additionally, we review key regulatory molecules such as microRNAs in HPV present during autophagy, and we emphasize the potential use of cancer treatments associated with autophagy in HPV‐related cancers.

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Use of Artemisinin and its Derivatives to treat HPV-Infected/Transformed Cells and Cervical Cancer: A Review

Cited by 17 publications

References 44 publications

Artesunate promotes Th1 differentiation from CD4+ T cells to enhance cell apoptosis in ovarian cancer via miR-142

Artesunate promotes Th1 differentiation from CD4+ T cells to enhance cell apoptosis in ovarian cancer via miR-142

Functional annotation of chemical libraries across diverse biological processes

Regulation of autophagy by high‐ and low‐risk human papillomaviruses

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