Determination of a novel carbamate AChE inhibitor meserine in mouse plasma, brain and rat plasma by LC–MS/MS: Application to pharmacokinetic study after intravenous and subcutaneous administration

Development of a validated LC–MS/MS method for the determination of ailanthone in rat plasma with application to pharmacokinetic study

“…The pharmacokinetic parameters of the three dosages calculated using noncompartmental analysis were shown in Table 3. In this study, it can be seen that the concentration of ailanthone in rat plasma after intravenous administration was relatively high although the dosages were lower than some other PK researches [19][20][21], which might be due to the good solubility of ailanthone. The t 1/2 were 105.5 ± 13.6, 113.3 ± 39.6 and 95.8 ± 23.9 min after administration of 0.5, 1.0, and 1.5 mg/kg ailanthone, respectively, which means that ailanthone is eliminated fast in rats.…”