Dobrava Virus Carried by the Yellow-Necked Field Mouse <i>Apodemus flavicollis</i>, Causing Hemorrhagic Fever with Renal Syndrome in Romania

Panculescu-Gatej, Raluca; Sîrbu, Anca; Dinu, Sorin; Waldstrom, Maria; Heyman, Paul; Murariu, Dimitru; Petrescu, A; Szmal, Camelia; Oprişan, Gabriela; Lundkvist, Åke; Ceianu, Cornelia Svetlana

doi:10.1089/vbz.2013.1400

Cited by 3 publications

(3 citation statements)

References 17 publications

(18 reference statements)

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“…Three A. flavicollis rodents were infected with DOBV and the sequences were very similar to those from reported HFRS cases. Phylogenetic analysis revealed that two variants of DOBV circulate in Romania . In Albania, 263 small mammals were trapped during 2006‐2007; 10 of 148 A. flavicollis rodents were found to be infected with DOBV …”

Section: Discussionmentioning

confidence: 99%

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Dobrava hantavirus variants found in Apodemus flavicollis mice in Kırklareli Province, Turkey

Polat

Sironen²,

Plyusnina³

et al. 2018

Journal of Medical Virology

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Hantaviruses infect humans via inhalation of viral particles within secretions of infected rodents or rarely through direct contact with infected rodents. Determining the prevalence of hantavirus infections among rodent populations is of vital importance to obtain information on hantavirus-related cases and to predict possible outbreaks. We hypothesized that DOBV strains circulating in the Thrace Region in Turkey would be related to other Balkan DOBV strains. In this study, hantavirus infections in the rodent population of the Kırklareli-İğneada Region (north-western Turkey, near the Bulgarian border) were investigated. This region is of particular importance, as it is located in the south-eastern margin of the European continent and was used as an entrance point of Asian faunal elements into Europe. DOBV infection was detected in eight of 73 rodents; all were of the Apodemus flavicollis species. Partial sequences of the viral S-, M-, and L-genome segments were recovered and compared with previously reported DOBV sequences. The newly characterized Turkish strains were similar to other DOBV variants. Silent nucleotide mutations were dominant. The hantavirus prevalence in the İğneada region was similar to what has been reported in Greece and Bulgaria. For the first time, the M-segment sequences of DOBV from Turkey were recovered and genetic data of hantaviruses from Thrace region of Turkey were obtained.

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Section: Discussionmentioning

confidence: 99%

“…Prevention is important due to the lack of effective antivirals . Surveillance offers important data on the infection in wildlife and hantavirus prevalence and thus facilitates prediction of possible outbreaks …”

Section: Introductionmentioning

confidence: 99%

Dobrava hantavirus variants found in Apodemus flavicollis mice in Kırklareli Province, Turkey

Polat

Sironen²,

Plyusnina³

et al. 2018

Journal of Medical Virology

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“…From eight children included in our study, seven were infected with the Dobrava serotype. Panculescu-Gatej et al demonstrated in a study that there are two strains of the Dobrava virus that circulated in rodent populations and transmitted to humans in Romania, and that both belong to the group of Dobrava strains circulating in Southeastern and Central Europe [47]. Till now, the literature does not specify evidence of the effectiveness of any antiviral drug for HFRS or HPS.…”

Section: Evolutive and Therapeutic Features In The Diseasementioning

confidence: 99%

Hantavirus Infection in Children—A Pilot Study of Single Regional Center

Mocanu

Cajvan²,

Lazaruc

et al. 2023

Viruses

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Background: Hantaviruses are infectious etiological agents of a group of rodent-borne hemorrhagic fevers, with two types of clinical manifestations in humans: hantavirus pulmonary syndrome (HPS) and hemorrhagic fever with renal syndrome (HFRS). According to available statistics, the disease occurs mainly in adults, but the lower incidence in the pediatric population might also be related to a lack of diagnosis possibilities or even unsatisfactory knowledge about the disease. Materials and Methods: The purpose of this study was to evaluate the cases of hemorrhagic fever with renal syndrome diagnosed and treated in the Department of Nephrology at St. Mary’s Emergency Hospital for Children in Iasi, Romania, representative of the North-East of Romania. We also reviewed the specialized literature on the topic. Results: Between January 2017 and January 2022, eight cases of HFRS, all men, and seven from rural areas, aged 11–18 years old, were referred to our clinic because of an acute kidney injury (AKI). Seven cases were identified as Dobrava serotype while one case was determined by Haantan serotype. Conclusions: HFRS should always be considered as a differential diagnosis when faced with a patient with AKI and thrombocytopenia. Dobrava serotype is the most common hantavirus subtype in the Balkans. For the specific prevention of human infections, mainly in high-risk groups, vaccines are needed. As far as we know, this is the first study on HFRS in Romanian children.

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Hantaviruses as Emergent Zoonoses: A Global Threat

Mahapatra

2023

Emerging Human Viral Diseases, Volume I

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Dobrava Virus Carried by the Yellow-Necked Field Mouse Apodemus flavicollis, Causing Hemorrhagic Fever with Renal Syndrome in Romania

Cited by 3 publications

References 17 publications

Dobrava hantavirus variants found in Apodemus flavicollis mice in Kırklareli Province, Turkey

Dobrava hantavirus variants found in Apodemus flavicollis mice in Kırklareli Province, Turkey

Hantavirus Infection in Children—A Pilot Study of Single Regional Center

Hantaviruses as Emergent Zoonoses: A Global Threat

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